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Highly refractory Archaean peridotite cumulates : Petrology and geochemistry of the Seqi Ultramafic Complex, SW Greenland

This paper investigates the petrogenesis of the Seqi Ultramafic Complex, which covers a total area of approximately 0.5 km2. The ultramafic rocks are hosted by tonalitic orthogneiss of the ca. 3000 Ma Akia terrane with crosscutting granitoid sheets providing an absolute minimum age of 2978 ± 8 Ma for the Seqi Ultramafic Complex. The Seqi rocks represent a broad range of olivine-dominated plutonic

Anchorless cooperative tracking using multipath channel information

Highly accurate location information is a key facilitator to stimulate future services for the commercial and public sectors. Positioning and tracking of absolute positions of wireless nodes usually requires information provided from technical infrastructure, e.g., satellites or fixed anchor nodes, whose maintenance is costly and whose limited operating coverage narrows the positioning service. In

PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many normal physiological functions and the pathophysiology of several diseases. Since the discovery and introduction of sildenafil, inhibitors of PDE5 have been the first-line therapy for erectile dysfunction (ED). The success of sildenafil in the treatment of ED stimulated research in the field of PDE5 inhibiti

Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus SU

We previously reported a strategy to redirect the retroviral host range by expressing single-chain antibodies (S. J. Russell, R. E. Hawkins, and G. Winter, Nucleic Acids Res. 21:1081-1085, 1993) or ligands (F.-L. Cosset, F. J Morling, Y. Takeuchi, R. A. Weiss, M. K. L. Collins, and S. J. Russell, J. Virol. 69:6314-6322, 1995) at the N terminus of Moloney murine leukemia virus (MoMLV) surface prote

Antibody response in immunized rabbits measured with bacterial immunoglobulin-binding proteins

Protein G, an immunoglobulin (Ig)-binding protein isolated from group C or G streptococci, binds to the Fc portion of IgG. Protein L, from the anaerobic bacterium Peptostreptococcus magnus, specifically binds light chains of Ig. In this study, protein G and L were used to measure the production of antibodies in immunized rabbits. Two rabbits were immunized with a mixture of human urinary proteins

How market size drove the localisation of knowledge hubs in the US

Knowledge hubs are generally located in large and dynamic population clusters, but there is little empirical evidence on what has driven the location of services in the economy, particularly the knowledge-intensive ones that form these hubs. This column describes how the geography of services across the US has been influenced by the interaction between county and industry characteristics. The pres

Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating

Proton acceleration by a pair of successive ultraintense femtosecond laser pulses

We investigate the target normal sheath acceleration of protons in thin aluminum targets irradiated at a relativistic intensity by two time-separated ultrashort (35 fs) laser pulses. When the full-energy laser pulse is temporally split into two identical half-energy pulses, and using target thicknesses of 3 and 6 μm, we observe experimentally that the second half-pulse boosts the maximum energy an

Protein biomarkers associated with pain mechanisms in osteoarthritis

Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. OA pain is multifactorial and may arise from multiple distinct or concurrent mechanisms, and may thus present as

Production and use of recombinant Aβ for aggregation studies

The amyloid β-protein (Aβ) is believed to play a central role in Alzheimer’s disease (AD) pathogenesis and there is great interest in understanding the process of Aβ aggregation, its underlying mechanism and the species generated during aggregation and their biological activity. Although Aβ has been studied for more than 30 years, analysis of its aggregation has been hampered by structural and che

Quality of nursing care as perceived by cancer patients : A cross-sectional survey in four European countries

Purpose: To explore and compare cancer patients' perceptions on the quality of nursing care in four European countries. Methods: Data were collected in Cyprus, Finland, Greece and Sweden. The sample comprised 596 hospitalized cancer patients. The quality of nursing care was measured using the “Oncology Patients' Perceptions of the Quality of Nursing Care Scale” (OPPQNCS). Patient characteristics w

On the Role of Envisioned Futures in Sustainability Transitions

Visioner och framtidsbilder efterfrågas ofta för att motivera och inspirera till samhälleliga förändringar. Sådana visioner kan bygga på politisk förändring eller måla upp bilder av teknisk utveckling som hjälper oss att lösa svåra samhälleliga problem. Den typen av visioner är kanske speciellt viktiga när vi strävar efter en hållbar utveckling, och framför allt ifall vi vill motverka att jordens Different kinds of representations of the future are often asked for in order to motivate and inspire societal change. These envisioned futures can be based on political or behavioural change, or may visualize technical developmentwhich could help us solve complex societal problems. The latter type of epresentation is especially important if we aim for sustainable development, and even more so if