Polyamine analogues inhibit neuroblastoma cell growth
Popular Abstract in Swedish Summary in Swedish Populärvetenskaplig sammanfattning Neuroblastom uppstår ur omogna nervceller i binjurarna eller i nervvävnaden bredvid ryggraden och är den vanligaste extrakraniala solida tumörformen hos barn. Varje år drabbas ca 10-15 barn i Sverige och sjukdomen uppkommer vanligast hos barn under 4 år. Trots enorma framgångar med behandlingsformer, så som cytostatAbstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. Polyamines are needed for cell proliferation and cell survival. Th