Effects of mixed surfactant system on chemical and physical stability of human growth hormone
In protein formulation, addition of surfactants is commonly executed to enhance product stability and shelf-life. The reason is that surfactants can protect proteins against surface-induced aggregation. However, the interaction between surfactant and protein depends on the type of surfactant used. Anionic surfactants can unfold proteins and form complexes in equilibrium manner. The complex structu
