The Bicoid (Bcd) protein is a primary determinant of early anterior-posterior (AP) axis specification in Drosophila embryogenesis. This morphogen is spatially distributed in an anterior-high gradient, and affects particular AP cell fates in a concentration-dependent manner. The early distribution and dynamics of the bicoid (bcd) mRNA, the source for the Bcd protein gradient, is not well understood

Cities are expected to contribute to climate mitigation by providing effective climate policy actions in a multilevel governance context. Yet, it is unclear what we actually know about the strengths and weaknesses of urban climate policy measures and how municipal policy learning could be enhanced. In this article we present a comprehensive review on cities’ experience in climate mitigation policy

Mechanical loading affects tendon healing and recovery. However, our understanding about how physical loading affects recovery of viscoelastic functions, collagen production and tissue organisation is limited. The objective of this study was to investigate how different magnitudes of loading affects biomechanical and collagen properties of healing Achilles tendons over time. Achilles tendon from f

This article examines the factors explaining whether or not Swedish social workers experience technostress, and highlights examples of situations when social workers experience it. The article draws on a web survey (N = 523) via a quantitative analysis of responses and a qualitative analysis of answers to an open-ended question. Approximately one-third of social workers surveyed experienced techno

Hepatocellular carcinoma (HCC), the third major cause of cancer mortality, can result from non-alcoholic steatohepatitis (NASH). Due to limited efficacy of drugs approved for HCC and no drug available yet for NASH, identification of new effective treatments is crucial. Here, we investigated whether NV556, a cyclophilin inhibitor derived from sanglifehrins, would decrease the development of NASH an

This study critically evaluates David Harvey’s model of urban land rent and its centrality in his explanation of the material forces that underlie and limit urban land policies, strategies, planning decisions, and investment choices. Harvey emphasizes structural forces of capital in relating economic urbanization processes to uneven patterns of capitalist development, recurrent economic crises of

Antibodies are central to acquired immunity against malaria. Plasmodium falciparum elicits antibody responses against many of its protein components, but there is also formation of antibodies against different parts of the red blood cells, in which the parasites spend most of their time. In the absence of a decisive intervention such as a vaccine, people living in malaria endemic regions largely d

Shot over a six-year period (2009-15) mainly in the industrial heartland of south China, a major hub in the global supply chain, this film follows labor activists as they find common grounds with workers, helping them to negotiate with local officials and factory owners over wages and working conditions. Threats, attacks, detention and boredom become part of their daily lives as they struggle to s

The paper aims to identify and analyse potential legal avenues for phasing out fossil fuel subsidies (FFS) in the European Union (EU) using State aid rules. Our analysis reveals that the EU State aid rules would allow the European Commission to effectively target and monitor a vast number of FFS. From a policy perspective, the requirements for notification, examination, transparency, reporting, an

Objective: Previous studies of the consequences of unilateral hearing loss (UHL) on the functional-structural organization of the brain has included subjects with various degrees of UHL. We suggest that the consequences of a total loss of hearing in one ear might differ from those seen in subjects with residual hearing in the affected ear. Thus, the main aim of the present study was to compare the

The effect of myeloid leukaemic cells, cells of the promyelocytic cell line HL-60 and normal polymorphonuclear granulocytes (PMN), enclosed in dialysis tubes, on the aggregation of allogeneic normal platelets after induction with arachidonic acid (AA) and with adenosine diphosphate (ADP) was investigated in vitro. Inhibition of aggregation was seen after preincubation of the platelets with leukaem

Objectives Pregnancy complications are common contributors to perinatal mortality and morbidity. Still, the cause(s) of gestational hypertensive disorders and diabetes are largely unknown. Some occupational exposures have been inconsistently associated with pregnancy complications, but exposure to whole-body vibrations (WBV) has been largely overlooked even though it has been associated with adver

Background: Breast cancer-related lymphedema (BCRL) is associated with impaired function and poorer quality of life. BCRL is also considered time-consuming and costly to treat. While compression treatment is considered the most efficient and effective form of treatment for early BCRL, its impact on the lymphatic system highlights its potential in the prevention of lymphedema. Objectives: To identi

This paper examines the complementarity between the market for electric vehicles and fast charging on the Swedish market from the introduction of these technologies on the market until the third quarter 2015. Three ecosystems are identified based on the standards Chademo, CCS and the Tesla proprietary charging technology. The analysis points to the need for studying markets for electric vehicles a