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Segmental gain of chromosome 17q is the most common genetic aberration in high-risk neuroblastoma, but its role in disease progression is poorly understood. This study aims to address the contribution of 17q gain to neuroblastoma malignancy. We analyzed the genetic and transcriptional landscape of 417 neuroblastoma patients across various risk groups and clinical stages using multi-omic approaches

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade

The relationship between degree of coronary artery stenosis and its effect on myocardial perfusion is complex and constitutes a clinical challenge. The aim of this study was to assess diagnostic accuracy of visual assessment of invasive coronary angiography (ICA) for detecting reduced myocardial perfusion determined by quantitative first-pass perfusion (qFPP) cardiac magnetic resonance (CMR) in pa

In this work we investigate the development of functionally graded cemented carbides, featuring macro gradients on the millimeter scale, where Fe, or Ni is the binder phase. Two composites, WC-Ni and WC-Fe with 20 % binder by volume were produced by addition of TiC on the surface of the samples before sintering at 1475 °C for 1 h. The sintered samples were analyzed using electron microscopy and mi

Many women are occupationally active during pregnancy. The aim of this study was to investigate associations between exposure to chemicals during pregnancy and the risk of gestational diabetes or preeclampsia. The cohort included singleton births in Sweden between 1994 and 2014. The cohort was limited to low-educated mothers to reduce potential confounding from unidentified life-style associated f

Despite the importance of mineral-associated organic matter (MAOM) in long-term soil carbon (C) and nitrogen (N) persistence, and the significant contribution of fungal necromass to this pool, the factors controlling the formation of fungal-derived MAOM remain unclear. This study investigated how fungal necromass chemistry, specifically melanin, interacts with soil mineral properties and microbial

In this paper, we present a framework to identify discrete-time, single-input/single-output, switched linear systems (SISO-SLSs) from input–output data measurements. Continuous state is not assumed to be measured. The key step is a deadbeat observer-based transformation of the SLS model to a switched auto-regressive with exogenous input (SARX) model. Discrete states are estimated by a three-stage

Climate anxiety is gaining increasing attention but how it is related to both impairment and climate change activism through the use of emotion-focused coping strategies is still poorly understood. We conducted two studies to help understand psychological predictors for climate anxiety-related impairment (Study 1) and gain insights into the roles of trait mindfulness and emotion regulation for dif

Soil erosion is a critical process influencing the global carbon cycle. However, erosion-induced carbon changes remain inadequately understood, particularly for soil inorganic carbon (SIC). There is also limited knowledge about the factors influencing soil carbon dynamics during erosion processes. Here we quantify the global translocation of soil organic carbon (SOC) and SIC due to soil erosion us

Quantifying the spatial and temporal patterns of drought characteristics is crucial, given the increasing frequency and intensity of drought events over the past 20 years in China. However, the patterns of drought frequency and duration in different regions and their differences remain unclear. Traditional indices for detecting and quantifying droughts, such as the Standardized Precipitation Evapo

The power extracted by reverse electrodialysis (RED) is often limited by the high resistance of low concentration compartment. This work aims to address this issue by demonstrating a reverse electrodeionization (REDI) design that can facilitate the ion transport and alleviate so called spacer shadow effects. In total, three different stack designs were assembled by substituting the conventional sp

An adaptive controller is proposed and analyzed for the class of infinite-horizon optimal control problems in positive linear systems presented in (Ohlin et al., 2024b). This controller is derived from the solution of a “data-driven algebraic equation” constructed using the model-free Bellman equation from Q-learning. The equation is driven by data correlation matrices that do not scale with the n

This paper presents a novel adaptive autotuning strategy for controlling the pH in microalgae raceway reactors, a critical variable in optimizing biomass productivity under dynamic environmental conditions. The method expands on existing relay-based autotuning principles, tailored to suit the seasonally variable dynamics of microalgae cultivation systems influenced by CO2 injection and photosynthe

An unusually direct warning from Japanese authorities offers a rare opportunity to confront the deeper systems at work.

The report presents a bibliography of academic literature on transdisciplinary urban research. It includes journal articles, book chapters, and reports that engage with a wide range of theories, methods, evaluation techniques, and experiences of academic and non-academic stakeholders who conduct collaborative research on or related to cities.

Firstly, we completely determine the self-similar Hausdorff spectrum of the group of q-adic automorphisms where q is a prime power, answering a question of Grigorchuk. Indeed, we take a further step and completely determine its Hausdorff spectra restricted to the most important subclasses of self-similar groups, providing examples differing drastically from the previously known ones in the literat

The aim of this report is to provide insights on the expertise, knowledge, and experiences of conducting transdisciplinary urban research. To gather insights, we developed a set of questions based on a review of transdisciplinary research publications from 2010 to 2023 in the disciplines of Architecture, Planning, Geography, Urban Studies, and Sustainability Science. We used these questions as a g

This report summarises the insights we developed by conducting a literature review of the dominant approaches and experiences of transdisciplinary urban research. We conducted a World Wide Web search to identify key academic and non-academic publications between 2010 and 2023 in the disciplines of Architecture, Planning, Geography, Urban Studies, and Sustainability Science. We focused on those con

This report provides a summary of 11 visualisations that have been developed by scholars who are engaged in transdisciplinary urban research. We identified the visualisations through a review of academic literature in the disciplines of Architecture, Planning, Geography, Urban Studies, and Sustainability Science between 2010 to 2023. Some of the visualisations are original while others are derived