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QM/MM study of the catalytic reaction of aphid myrosinase

Brevicoryne brassicae, an aphid species, exclusively consumes plants from the Brassicaceae family and employs a sophisticated defense mechanism involving a myrosinase enzyme that breaks down glucosinolates obtained from its host plants. In this work, we employed combined quantum mechanical and molecular mechanical (QM/MM) calculations and molecular dynamics (MD) simulations to study the catalytic

Decoding the rhizodeposit-derived carbon's journey into soil organic matter

Net rhizodeposition corresponds to the portion of living root carbon (C) that remains in the soil after microbial processing and partial decomposition. Although it is assumed that this C input exerts an important role in the formation of soil organic matter (SOM), its contribution to distinct SOM pools is still not fully understood. In this study, we aimed to (i) quantify the retention of net rhiz

Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients with Acute Ischemic Stroke

BACKGROUND: Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo. In ischemic stroke, the progression of pathology involves changes in microvascular signal

Bismuth-oxide nanoparticles: study in a beam and as deposited

Bi2O3 is a promising material for solid-oxide fuel cells (SOFC) due to the high ionic conductivity of some phases. The largest value is reached for its δ-phase, but it is normally stable at temperatures too high for SOFC operation, while nanostructured oxide is believed to have more suitable stabilization temperature. However, to manufacture such a material with a controlled chemical composition i

Assessment of a hand-held CZT-based gamma camera for pre-clinical imaging of 177Lu

A small CdZnTe-based hand-held gamma-camera has been acquired, intended to be used for preclinical imaging. The camera produces images of size 4 cm x 4 cm with an image-matrix of 16 x 16 pixels and can be equipped with a low-energy high-sensitivity (LEHS) or a high-resolution (LEHR) parallel-hole collimator. Pre-clinical imaging involves scales smaller than what the camera is typically used for, a

Why does urban Artificial Intelligence (AI) matter for urban studies? : developing research directions in urban AI research

New digital technologies and systems are being extensively applied in urban contexts. These technologies and systems include algorithms, robotics, drones, Autonomous Vehicles (AVs) and autonomous systems that can collectively be labelled as Artificial Intelligence (AI). Critical debates have recognized that these various forms of AI do not merely layer onto existing urban infrastructures, forms of

Omställning till elbussar : Lärdomar, erfarenheter och rekommendationer

På senare år har elektrifiering av stadsbussar i kollektivtrafiken växlat upp i tempo och idag finns flera exempel på hur man har hanterat omställningen i svensk kollektivtrafik. I projektet e(+)bus har vi jobbat med fallstudier i Sverige (Stockholm, Göteborg, Malmö, Jönköping, Ystad, Piteå). Vi har även gjort en internationell utblick till Norge (Oslo och Trondheim) samt Nederländerna (Eindhoven)

Trafiksäkerhetsgranskning : Genomgång av några länders manualer/riktlinjer

Fyra manualer/riktlinjer har gåtts genom enligt internationella bästa praktik kriterier. Dessa fyra manualer/riktlinjer valdes då trafiksäkerhetsgranskning som en systematisk procedur startade i England och dess grundläggande principer förfinades i Australien. Det är också av intresse hur Sveriges grannländer, Danmark och Norge har utvecklat sina egna nationella manualer.

Trafiksäkerhetsgranskning - Riktlinjer

Baserat på genomgång av internationellt etablerade bästa praktik riktlinjer och fyra länders (Australien England, Danmark och Norge) manualer/riktlinjer har riktlinjer för trafiksäkerhetsgranskning i Sverige utarbetats.

Proving gender and sexuality in the (homo)nationalist Greek asylum system : Credibility, sexual citizenship and the ‘bogus’ sexual other

The aim of this article is to analyse and critique Greek authorities’ expectations for a ‘credible’ account in queer asylum claims. As some of the caseworkers’ accounts portray, through 16 semi-structured interviews, in order to be deemed ‘credibly queer’ applicants are expected to have passed through a painful, discursively narratable process of self-realization and have suffered enough in their

A bowhead whale vertebra embedded in marine limit beach sediment on Barentsøya, Svalbard

A cross-valley beach terrace in Iladalen in the south-eastern corner of Barentsøya (Svalbard) is interpreted as built by long-shore sediment transport and deposition, with its maximum height at 88 m a.s.l., marking the marine limit (ML) at deglaciation. A whale vertebra (most probably from a bowhead whale, Balaena mysticetus) was found embedded in the upper part of the littoral sediments at a hei

The open abdomen in trauma, acute care, and vascular and endovascular surgery : comprehensive, expert, narrative review

Background: The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular sur

Cardiovascular events, mortality, early retirement and costs in >50 000 persons with chronic heart failure in Sweden

Aims: We aimed to examine cardiovascular events (stroke and myocardial infarction [MI]), mortality, early retirement and economic costs over 5 years in people with chronic heart failure (CHF) and matched controls in Sweden. Methods and results: Individuals (aged ≥16 years) living in Sweden on 1 January 2012 were identified in an existing database. Individuals with CHF were propensity score matched

Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer

This study aims to combine computed tomography (CT)-based texture analysis (QTA) and a microbiome-based biomarker signature to predict the overall survival (OS) of immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients by analyzing their CT scans (n = 129) and fecal microbiome (n = 58). One hundred and five continuous CT parameters were obtained, where principal comp

Tying Shock Features to Impact Conditions : The Significance of Shear Deformation During Impact Cratering

Impact cratering is associated with extreme physical conditions with temperatures and pressures far exceeding conditions otherwise prevailing at the surfaces of terrestrial planets. As a consequence, shock-metamorphosed rocks contain unique deformation features such as planar deformation features in quartz, high-pressure mineral polymorphs and melted rock. While the physical conditions of formatio

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer

Forest wood borers (FWB) cause severe tree damage and economic losses worldwide. The release of entomopathogenic fungi (EPF) during the FWB emergence period is considered an acceptable alternative to chemical control. However, EPF resources have been significantly less explored for FWBs, in contrast to agricultural insect pests. This paper presents a protocol for exploring EPF resources from FWBs

Citizenship and mobility of the poor: Sweden during the 19th century

The distinctive features of the modern form of citizenship include, among other things, that it is both internally inclusive and externally exclusive; that it establishes legal equality so that membership of the state supersedes all other memberships and allegiances; and that it defines membership as independent of residence. These characteristics largely evolved during the “long nineteenth centur

SAI-CH-6 : Development of a Short Form of the State Anxiety Inventory for Children At-Risk for Type 1 Diabetes

Objective: To develop a reliable and valid short form of the State Anxiety Subscale of the State-Trait Anxiety Inventory for Children (STAI-CH) in the Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: A Development Sample of 842 10-year-old TEDDY children completed the STAI-CH State Subscale about their type 1 diabetes (T1D) risk. The best 6 items (three anxiety-present a