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BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy

Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor

Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associated with an increased T1D risk in offspring. These identified epidemiological associations were further assessed in 470,000 genotyped Finns from the FinnGen stu

BACKGROUND: The risk of infection-related death is high in patients undergoing dialysis. This study aimed to identify the modifiable risk factors for PD-related infections in patients undergoing peritoneal dialysis.METHODS: This was a population-based retrospective cohort study conducted in Skåne, South Sweden, which included all patients receiving peritoneal dialysis (PD) between 2011 and 2020. T

An abnormal blood pressure (BP) response on standing is associated with atherosclerotic cardiovascular disease (CVD). The role of physical activity (PA) on orthostatic BP-reactions and its relation to subclinical atherosclerosis is unclear. We aimed to assess the association between PA and orthostatic BP-reactions, and whether PA modifies the relationship between orthostatic BP-reactions and subcl

This thesis analyzes the effects of technological change using the case ofelectrification in 20th-century Sweden. It begins with a systematic literaturereview that identifies gaps in the quantitative research on historical jobdisplacement before 1980. In Sweden, electrification enhanced labor andreduced income inequality. Analysis of 1930 census data shows that earlyelectricity access raised incom

Teams are dynamic systems that develop, adapt, and change as members interact and respond to their environments. Theory in organizational research emphasizes that team phenomena are multilevel, temporal, and often nonlinear. Yet, the statistical methods commonly used to study teams have lagged behind these theoretical advances, limiting empirical progress. This dissertation addresses this methodol

Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer’s disease (AD). Estimating brain progression patterns can be applied to understanding the therapeutic effects of amyloid-clearing drugs in research and detecting the earliest sign of accelerated atrophy in clinical settings. However, most state-of

We propose an extended Left-Right symmetric model with an additional global U(1)X symmetry, which collapses to a residual subgroup ℤ2 after spontaneous symmetry breaking. In this model, the light active neutrino masses are generated via a double seesaw mechanism with the Dirac submatrix arising at one loop. In addition, the masses of the charged fermions of the Standard Model (SM) that are lighter

Background: We aimed to study the long-term effect of smoking on coronary atherosclerosis progression at the segmental level. Methods: Angiographic data (1989-2017) on current, former, and nonsmokers were collected from the Swedish Coronary Angiography and Angioplasty Registry. The Western Denmark Heart Registry was used to validate the results. Patients with clinically indicated angiography with

Background and objective: We established prognostic nomograms incorporating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) parameters standardised by Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP1). Here, we develop an updated PPP2 risk score from a large international multicentre registry study. Methods: We included 6128 prostate cancer pati

[Background/Context] AI assistants like GitHub Copilot are transforming software engineering; several studies have highlighted productivity improvements. However, their impact on code quality, particularly in terms of maintainability, requires further investigation. [Objective/Aim] This study aims to examine the influence of AI assistants on software maintainability, specifically assessing how the

Group Exhibition. Carlier-Gebauer. September - October 2025.Fluid Systems explores fluidity as a site of metamorphosis: a continuous, ideologic process in which gender, identity, and social constructs dissolve into transient states of becoming. Engaging with the transcendence of fixed categories, it foregrounds phenomena that resist comprehension, gesturing toward the unknown as both subject and m

This thesis offers a comprehensive account of the emergence and evolution of Maumaus—an art organisation dedicated to education, curation, and production founded in Lisbon in 1992. Through an analysis of its history and the values and principles that underpin its programmes, this (auto)biography of the organisation—produced by a practitioner who is himself inextricably bound in this history—conduc

This commentary argues that the concept of ‘polycrisis’ must be critically reoriented through a decolonial lens,particularly about the global South, where overlapping crises have long been the norm. While ‘polycrisis’ hasbecome a buzzword among global economic and political elites, scholars have studied its relevance mainly forthe global North. Using the climate and debt crises as two entry points

Fully precise static analysis of program behavior is undecidable in theory and infeasible in practice. While individual static analyses can prove specialized invariants about program behavior or resolve narrow ambiguities, real programs are complex composites of many different abstractions and programming patterns. State-of-the-art approaches to program analysis thus generally rely on composite an

ABB IRB4600 industrial robot mounted on a spindel crane unit for mobility. Transported and hosed in container.