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Forskare i Lund har upptäckt en antitoxinmekanism som tycks kunna neutralisera hundratals olika toxiner och därmed skydda bakterier mot virusattacker. Mekanismen har fått namnet Panacea, efter den grekiska medicinens gudinna vars namn har blivit synonymt med universellt botemedel. Förståelsen av bakteriella toxin- och antitoxinmekanismer kommer att vara avgörande för framtida framgångsrik fagterap

https://www.medicin.lu.se/artikel/multifunktionell-pa-och-avknapp-hammar-bakterietillvaxt - 2026-01-19

Ett tvärvetenskapligt forskarteam vid Lunds universitet har på ett innovativt sätt lyckats med något som länge varit ett stort problem inom stamcellsforskningen. Nämligen att på ett skonsamt sätt föra in terapeutiska biomolekyler i målcellen för att öka dess tillväxt. Projektet har nu tilldelats anslag Proof of Concept från Europeiska forskningsrådet, ERC. Jonas Larsson, professor i molekylärmedic

https://www.medicin.lu.se/artikel/sa-kan-nano-ror-oka-antalet-blodstamceller - 2026-01-19

Hallå där, Nils-Eric Sahlin, du fick ett brev från Europakommissionens ordförande Ursula von der Leyen! Berätta? – Brevet handlade om att EU-kommissionen nyligen beslutat att jag ska ingå i den etiska grupp som är rådgivande till presidenten och kommissionären för forskning inom EU. Under pandemin har gruppen med det krångliga namnet European Group on Ethics in Science and New Technologies inte tr

https://www.medicin.lu.se/artikel/i-eu-kommissionens-tjanst - 2026-01-19

Maten vi äter påverkar inte bara kroppen utan även knoppen. Forskare vid Lunds universitet strävar efter att förstå hur en kost med mycket fett och socker påverkar minnesförmågor i samband med övervikt och typ 2-diabetes. Deras nya studie på möss visar att fet mat och sockersötad dryck leder till försämringar av minnet, men att det går att vända utvecklingen. Övervikt är en riskfaktor för att utve

https://www.medicin.lu.se/artikel/en-kost-rik-pa-fett-och-socker-forsamrade-minnet-hos-moss-men-inte-gott - 2026-01-19

Graviditet kan medföra ökad risk för att bli sjuk i tuberkulos (tbc). Särskilt för kvinnor som bär på tbc-bakterier och därmed har latent, eller vilande, tbc. Dagens diagnostiska tekniker har svårt att upptäcka latent tbc, särskilt när en individs immunförsvar är förändrat som exempelvis vid graviditet. Dessutom är det okänt hur immunförsvarets egen kontroll av latent tbc påverkas under en gravidi

https://www.medicin.lu.se/artikel/ny-avhandling-kastar-ljus-pa-gravidas-immunforsvar-vid-latent-tuberkulos - 2026-01-19

Nya kursen Klimakteriet, menopaus och kvinnors hälsa vid Lunds universitet blev snabbt en succé med 424 sökande. 40 platser finns på kursen, som går helt på distans och kan sökas av flera olika professioner som på något sätt möter kvinnor i klimakteriet i sitt arbete. – Det är ett enormt söktryck, jag får mejl nästan varje dag från de som är besvikna att de inte kommit in, säger kursansvarig Perni

https://www.medicin.lu.se/artikel/popular-kurs-ger-fordjupad-kunskap-om-klimakteriet - 2026-01-19

Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use in the field of pain. R

https://www.lupop.lu.se/article/perspectives-pain-registries - 2026-01-19

Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality ratio or hazard ratio to

https://www.lupop.lu.se/article/translating-all-cause-mortality-rate-ratios-or-hazard-ratios-age-longevity-and-probability-based - 2026-01-19

Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −9

https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2026-01-19

Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in some way to the constr

https://www.lupop.lu.se/article/constructed-measures-and-causal-inference-towards-new-model-measurement-psychosocial-constructs - 2026-01-19

Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and interpretations are un

https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2026-01-19

Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compare statistical methods

https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2026-01-19

The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing participants with non-

https://www.lupop.lu.se/article/cohort-profile-and-representativeness-participants-diet-cancer-and-health-next-generations-cohort - 2026-01-19

Karin Larsson's presentation from the GIS seminar is now available Read more here.

https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2026-01-19

Recruiting participants to a clinical study is a resource-intensive process with a high failure rate. The Scottish Health Research Register (SHARE) provides recruitment support service which helps researchers recruit participants by searching patients’ Electronic Health Records (EHRs). The current study aims to evaluate the performance of SHARE in participant recruitment. Read the paper at https:/

https://www.lupop.lu.se/article/early-experience-opt-research-register-scottish-health-research-register-share-multi-method - 2026-01-19

Modern artificial intelligence techniques have solved some previously intractable problems and produced impressive results in selected medical domains. One of their drawbacks is that they often need very large amounts of data. Pre-existing datasets in the form of national cancer registries, image/genetic depositories and clinical datasets already exist and have been used for research. In theory, t

https://www.lupop.lu.se/article/registries-databases-and-repositories-developing-artificial-intelligence-cancer-care - 2026-01-19

Background: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time. Patients and Methods: We extracted systemic anticancer treatment procedures from the Danish Nati

https://www.lupop.lu.se/article/high-validity-danish-national-patient-registry-systemic-anticancer-treatment-registration-2009-2019 - 2026-01-19

The DMSKW is a valuable structure in providing safety data on drug exposure during pregnancy and lactation in combination with information on disease activity up to 6 years postpartum. This article will be the reference for describing the methods of future publications from the DMSKW. Read the paper at https://journals.sagepub.com/doi/10.1177/17562864211054956

https://www.lupop.lu.se/article/german-multiple-sclerosis-and-pregnancy-registry-rationale-objective-design-and-first-results - 2026-01-19

Sibling comparison studies have the attractive feature of being able to control for unmeasured confounding by factors that are shared within families. However, there is sometimes a concern that these studies may have poor generalizability (external validity) due to the implicit restriction to families that are covariate-discordant, i.e., those families where at least two siblings have different le

https://www.lupop.lu.se/article/generalizability-and-effect-measure-modification-sibling-comparison-studies - 2026-01-19

Collinearity can be a problem in regression models. When examining the effects of an exposure at different time points, constrained distributed lag models can alleviate some of the problems caused by collinearity. Still, some consequences of collinearity may remain and they are often unexplored. We aimed to illustrate the effects of collinearity in the context of distributed lag models, and to pro

https://www.lupop.lu.se/article/reflection-modern-methods-visualizing-effects-collinearity-distributed-lag-models - 2026-01-19