Published 2 November 2021 Vid verksamhetsområdet infektionssjukdomar på Skånes universitetssjukhus planeras en studie kring återfall av Clostridium difficile (nyligen namnbyte till Clodstridoides difficile). Studien ska utreda vilka faktorer som kan vara avgörande för att få fler återfall. Läs mer på https://www.lupop.lu.se/aterfall-av-clostridium-difficle

https://www.lupop.lu.se/article/ny-studie-fran-region-skane-aterfall-av-clostridium-difficle - 2025-03-14

Published 3 November 2021 In this article we discuss the potential for a weighted average of age-specific VE estimates to provide a more meaningful measure of overall VE. Read the paper at https://academic.oup.com/aje/article/190/10/1993/6217345

https://www.lupop.lu.se/article/causal-interpretation-overall-vaccine-effectiveness-test-negative-studies - 2025-03-14

Published 4 November 2021 The case time series design represents a general and flexible tool, applicable in different epidemiologic areas for investigating transient associations with environmental factors, clinical conditions, or medications. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/The_Case_Time_Serie…

https://www.lupop.lu.se/article/case-time-series-design - 2025-03-14

Published 5 November 2021 In this article, we discuss how to discern the causal mechanisms of interest in the sufficient cause model, which pays closer attention to the relationship between the sufficient cause model and the Bradford Hill viewpoints. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021-00798-6

https://www.lupop.lu.se/article/strength-causality-discerning-causal-mechanisms-sufficient-cause-model - 2025-03-14

Published 6 November 2021 The Danish randomized trial studying the effect of mask recommendation (DANMASK-19) was widely discussed in the media. We aimed to analyze this trial from a causal inference perspective. Read the paper at https://academic.oup.com/aje/article/190/10/2231/6279406

https://www.lupop.lu.se/article/use-nonparametric-bounds-causal-effects-null-randomized-trials - 2025-03-14

Published 8 November 2021 In this article, we illustrate that careful scrutiny based on the conventional sufficient cause model yields further insights into the concept of agonism in a more biologic sense. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/Marginal_Sufficient…

https://www.lupop.lu.se/article/marginal-sufficient-component-cause-model-emerging-causal-model-merits - 2025-03-14

Published 8 November 2021 In an extension of Mendelian randomization, we leveraged variation in genetic risk for late-onset AD risk to estimate the causal effect of AD on BMI and the earliest ages at which AD-related weight loss (or lower BMI as a proxy) occurs. Read the paper at https://academic.oup.com/aje/article/190/10/2163/6222073

https://www.lupop.lu.se/article/extension-mendelian-randomization-identify-earliest-manifestations-alzheimer-disease - 2025-03-14

Published 9 November 2021 Adjusting for epidemic curves based on surveillance data is necessary if estimates of missed cases and the effective reproduction number play a role in management of the COVID-19 pandemic. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/Effect_of_Adjustmen…

https://www.lupop.lu.se/article/effect-adjustment-case-misclassification-and-infection-date-uncertainty-estimates-covid-19-effective - 2025-03-14

Published 10 November 2021 We developed and validated a synthetic cohort approach to examine numbers of cardiovascular risk factors (CRFs) and adverse clinical events, including incident cardiovascular disease and all-cause mortality, across the life span from ages 20 years to 90 years. Read the paper at https://academic.oup.com/aje/article/190/10/2208/6274861

https://www.lupop.lu.se/article/development-and-validation-large-synthetic-cohort-study-cardiovascular-health-across-life-span - 2025-03-14

Published 11 November 2021 Smart card data (SCD) allow analyzing mobility at a fine level of detail, despite the remaining challenges such as identifying trip purpose. The use of the SCD may improve the understanding of transit users' travel patterns from precarious settlements areas, where the residents have historically limited access to opportunities and are usually underrepresented in surveys.

https://www.lupop.lu.se/article/big-data-big-issues-revealing-travel-patterns-low-income-population-based-smart-card-data-mining - 2025-03-14

Published 12 November 2021 Nationwide healthcare registries are potential important real-world data (RWD) sources for assessing drug effectiveness in oncology. However, it is unclear whether registry-derived RWD are suitable for clinical development. Read the paper at https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2424

https://www.lupop.lu.se/article/replication-oncology-randomized-trial-results-using-swedish-registry-real-world-data-feasibility - 2025-03-14

Published 13 November 2021 Despite progress toward curtailing opioid prescribing, physicians are often slow to adopt new prescribing practices. Using the Abdominal Core Health Quality Collaborative (ACHQC), we aimed to demonstrate the ability of a national, disease-specific, personalized registry to impact opioid prescribing. Read the paper at https://link.springer.com/content/pdf/10.1007/s10029-0

https://www.lupop.lu.se/article/utilization-national-registry-influence-opioid-prescribing-behavior-after-hernia-repair - 2025-03-14

Published 14 November 2021 The overall accuracy of data held in the New Zealand Trauma Registry (NZTR) is suitable for quality improvement and benchmarking purposes, but more work is needed to improve the accuracy of individual cases, particularly those with head/neck and chest injury. Read the paper at https://journals.sagepub.com/doi/full/10.1177/14604086211041877

https://www.lupop.lu.se/article/accuracy-injury-coding-trauma-registry - 2025-03-14

Published 15 November 2021 A well-managed institutional arthroplasty registry, including structured clinical and radiological follow-up assessments, offers the opportunity for high-quality long-term patient and arthroplasty outcome analysis. Such data are not only helpful for analyzing patient outcome and implant survival, but will be increasingly important to justify our daily clinical practice a

https://www.lupop.lu.se/article/establishing-institutional-reverse-total-shoulder-arthroplasty-registry - 2025-03-14

Published 16 November 2021 We developed standardized QA processes for training, certification and supervision of the MNHR, a multisite research registry. It is expected that these activities, together with ongoing QA processes, will help to further optimize data quality for this protocol. Read the paper at https://reproductive-health-journal.biomedcentral.com/articles/10.1186/…

https://www.lupop.lu.se/article/looking-beyond-numbers-quality-assurance-procedures-global-network-womens-and-childrens-health - 2025-03-14

Published 17 November 2021 This registry will assess outcomes in patients with genetically confirmed SMA and provide information on the effectiveness and long-term safety of approved and emerging treatments. Read the paper at https://content.iospress.com/articles/journal-of-neuromuscular-diseases…

https://www.lupop.lu.se/article/restore-prospective-multinational-registry-patients-genetically-confirmed-spinal-muscular-atrophy - 2025-03-14

Published 18 November 2021 Our findings suggest that in studies of air pollution and cardiometabolic disease, which use an adjustment strategy with a broad range of register-based socioeconomic variables, there is no effect on risk estimates from subsequent lifestyle adjustment. Read the paper at https://www.sciencedirect.com/science/article/pii/S0013935121011816

https://www.lupop.lu.se/article/effect-adjustment-register-based-and-questionnaire-based-covariates-association-between-air - 2025-03-14

Published 19 November 2021 The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually. Read the paper at https://link.springer.com/article/10.1007%2Fs10388-021-00879-1

https://www.lupop.lu.se/article/comprehensive-registry-esophageal-cancer-japan-2014 - 2025-03-14

Published 20 November 2021 Stroke is the second most common cause of adult death in Africa. This study reports the demographics, stroke types, stroke care and hospital outcomes for stroke in Freetown, Sierra Leone. Read the paper at https://www.frontiersin.org/articles/10.3389/fneur.2021.712060/full

https://www.lupop.lu.se/article/prospective-stroke-register-sierra-leone-demographics-stroke-type-stroke-care-and-hospital-outcomes - 2025-03-14

Published 21 November 2021 Among THR patients value sets based on the same method and perspective, a direct transfer of results across countries could be meaningful. In cases of differences in methods and perspectives among value sets, transfer of value sets across settings would have to consider conversion through crosswalk. Read the paper at https://www.mdpi.com/2077-0383/10/18/4205

https://www.lupop.lu.se/article/concordance-among-swedish-german-danish-and-uk-eq-5d-3l-value-sets-analyses-patient-reported - 2025-03-14