Published 25 December 2019 The best-fit model predicted risk for DA in S2 as a function of the log of kilometres between S1 and S2 with parameter estimates (±95% confidence intervals) of 0.94 (0.92; 0.95). Prediction of DA included effects of cohabitation and an interaction of proximity and time since S1 registration with stronger effects of proximity early in the follow-up period. Proximity effec

https://www.lupop.lu.se/article/geographical-proximity-and-transmission-drug-abuse-among-siblings-evaluating-contagion-model-swedish-0 - 2025-03-08

Published 25 December 2019 Major advances in cardiovascular medicine have been driven by innovations in basic research in biological and technical sciences. The subsequent testing in prospective randomized controlled trials (RCT) has provided the evidence underpinning the introduction of new, more effective, and safer treatments. New publication in European Heart Journal

https://www.lupop.lu.se/article/euroheart-european-unified-registries-heart-care-evaluation-and-randomized-trials - 2025-03-08

Published 26 December 2019 New publicatin in An International Journal of Obstetrics and Gynaecology

https://www.lupop.lu.se/article/surgical-registries-patient-reported-outcome-data-important-tools-monitoring-complications-after - 2025-03-08

Published 26 December 2019 As of 2019, Germany has still not been able to provide a national poisoning register and toxicovigilance for sufficient and reliable information on human exposure for the purpose of identification and assessment of toxic risk to the public. In particular, the USA acts as a special model, but France, the Netherlands, Switzerland, and Sweden also have efficient poisoning r

https://www.lupop.lu.se/article/national-poisoning-registers-and-toxicovigilance-different-countries-models-germany - 2025-03-08

Published 27 December 2019 More than 70% of patients with breast cancer present with node-negative disease, yet all undergo surgical axillary staging. We aimed to define predictors of nodal metastasis using clinicopathological characteristics (CLINICAL), gene expression data (GEX), and mixed features (MIXED) and to identify patients at low risk of metastasis who might be spared sentinel lymph node

https://www.lupop.lu.se/article/prediction-lymph-node-metastasis-breast-cancer-gene-expression-and-clinicopathological-models - 2025-03-08

Published 27 December 2019 A major challenge in clinical research today is the difficulty that studies have in meeting recruitment goals. Up to 48% of studies do not meet accrual goals within the specified timeframe, significantly delaying the progress of projects and the dissemination of findings. This pervasive problem is a recruitment crisis. We developed a representative, ethnically and racial

https://www.lupop.lu.se/article/developing-and-launching-research-participant-registry - 2025-03-08

Published 28 December 2019 The National Spinal Cord Injury Registry of Iran (NSCIR-IR) is a not-for-profit, hospital-based, and prospective observational registry that appraises the quality of care, long-term outcomes and the personal and psychological burden of traumatic spinal cord injury in Iran. Benchmarking validity in every registry includes rigorous attention to data quality. New publicatio

https://www.lupop.lu.se/article/national-spinal-cord-injury-registry-iran-nscir-ir-critical-appraisal-its-strengths-and-weaknesses - 2025-03-08

Published 28 December 2019 Vascunet has previously published an international comparison of registry data within vascular surgery. Data validity and completeness in participating registries is essential for a meaningful interpretation of differences between countries. The Vascunet collaboration has therefore developed a methodology for validation of international vascular registry data, previously

https://www.lupop.lu.se/article/international-validation-danish-vascular-registry-karbase-vascunet-report - 2025-03-08

Published 29 December 2019 The use of clinical autopsy has been in decline for many years throughout healthcare systems of developed countries despite studies showing substantial discrepancies between autopsy results and pre-mortal clinical diagnoses. We conducted a study to evaluate over time the use and results of clinical autopsies in Sweden. We reviewed the autopsy reports and autopsy referral

https://www.lupop.lu.se/article/cause-death-and-significant-disease-found-autopsy - 2025-03-08

Published 29 December 2019 Inflammatory bowel disease (IBD) is a chronic, inflammatory relapsing disease with increasing incidence. IBD research and long-term follow-up of patients have, however, been hampered by lack of detailed data on disease phenotype, patient-reported outcome measures, Physician Global Assessment, disease activity, and hospital-administered drugs. New publication in Scandinav

https://www.lupop.lu.se/article/swedish-inflammatory-bowel-disease-register-swibreg-nationwide-quality-register - 2025-03-08

Published 30 December 2019 The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. New publication in European Journal of Cancer Pr

https://www.lupop.lu.se/article/colorectal-cancer-diet-quality-index-inversely-associated-colorectal-cancer-malmo-diet-and-cancer - 2025-03-08

Published 30 December 2019 Orphan drugs are medicines intended to treat, prevent, or diagnose a rare and serious condition. The collection of pre-marketing safety and efficacy data for orphan drugs is very challenging for several reasons related to the rarity of the diseases. This highlights the need for robust post-marketing evidence generation. Real-world data sources, such as claims databases,

https://www.lupop.lu.se/article/role-healthcare-databases-and-registries-surveillance-orphan-drugs-real-world-setting-italian-case - 2025-03-08

Published 31 December 2019 Patient registries are routinely used in dermatology and psoriasis registries offer pertinent long-term safety information regarding conventional systemic therapies and biologic agents for psoriasis. New publication in Journal of Dermatological Treatment

https://www.lupop.lu.se/article/review-european-registries-psoriasis - 2025-03-08

Published 31 December 2019 Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2–) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study were to examine the agreement between molecular subtyping (MS) and surrogate subtyping and to identify subgroups consisting main

https://www.lupop.lu.se/article/agreement-between-molecular-subtyping-and-surrogate-subtype-classification-contemporary-population - 2025-03-08

Published 1 January 2020 Patient registries, ‘organised systems that use observational methods to collect uniform data on a population defined by a particular disease, condition, or exposure, and that is followed over time’, are potentially valuable sources of data for supporting regulatory decision-making, especially for products to treat rare diseases. Nevertheless, patient registries are greatl

https://www.lupop.lu.se/article/patient-registries-underused-resource-medicines-evaluation - 2025-03-08

Published 1 January 2020 To assess the impact on exposure time and outcome misclassifications, and consequent impact on exposure-outcome associations from treatment episode construction. We investigated the dosage assumptions of 1 unit per day, and 1 DDD per day, versus actual prescribed dosage under different handling of gaps and overlaps of prescriptions. New publication in European Journal of C

https://www.lupop.lu.se/article/methods-constructing-treatment-episodes-and-impact-exposure-outcome-associations - 2025-03-08

Published 2 January 2020 The aim of this study was to examine whether the self‐reported use of analgesics is associated with being a victim of bullying. New publication in Acta Paediatrica

https://www.lupop.lu.se/article/bullying-pain-and-analgesic-use-school-age-children - 2025-03-08

Published 2 January 2020 Sibling comparison designs have long been used to assess causal effects of exposures for which randomized studies are impossible and measurement of all relevant confounding is unobtainable. The idea is to utilize the fact that siblings often share a lot of unobserved variables. Therefore, it is proposed that in certain cases, comparing siblings is equivalent to comparing e

https://www.lupop.lu.se/article/what-causal-interpretation-sibling-comparison-designs - 2025-03-08

Published 3 January 2020 A central element of assimilation theory is that increasing time and number of previous immigrant generations in a host country leaves immigrants and their children more integrated and capable of navigating the host society. However, the underperformance of some immigrant groups in Sweden calls into question this relationship. Additionally, many studies regard intermarriag

https://www.lupop.lu.se/article/time-and-generation-parents-integration-and-childrens-school-performance-sweden-1989-2011 - 2025-03-08

Published 3 January 2020 The Swedish Twin Registry functions as research infrastructure containing information on 216,258 twins born between 1886 and 2015, of whom 86,199 pairs have zygosity determined by DNA, an intrapair similarity algorithm, or being of opposite sex. In essence, practically all twins alive and currently 9 years or older have been invited for participation and donation of DNA on

https://www.lupop.lu.se/article/swedish-twin-registry-content-and-management-research-infrastructure - 2025-03-08