Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. We used Illumina 450k microarrays to study correlations between epigenetic patterns in human adipose tissue and environmental factors such as h

Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. Neural correlates of cognitive and behavioral impairment in neonatal HIE, in particular in infants who survive without severe neuromotor impairment, are poorly understood. It is reasonable to hypothesize that

Denna avhandling undersöker en brist på konsensus inom den svenska litteraturvetenskapliga forskningen gällande såväl dess objekts grundläggande egenskaper, som vilka teorier och metoder för att studera detta objekt som är mest giltiga. Från perspektivet av denna brist, föreställd som en epistemologisk ”kris”, utforskas här möjligheterna för att betrakta detta sakförhållande som produktivt av kuns

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56

AbstractOverweight and obesity are more common among adult people with mobility disability (MD). Epidemiological studies are sparse in Sweden when it comes to the prevalence of MD and weight, differences between people with MD compared to those without MD, as well as the association to HRQoL. In addition, general guidelines in obesity prevention and treatment adapted to people with MD are lacking

The early Cambrian Sirius Passet fauna of northernmost Greenland (Cambrian Series 2, Stage 3) contains exceptionally preserved soft tissues that provide an important window to early animal evolution, while the surrounding sediment holds critical data on the palaeodepositional water-column chemistry. The present study combines palaeontological data with a multiproxy geochemical approach based on sa

The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of individual amino acid residues in protein sequences, we investigate separately all

The Intergovernmental Panel on Climate Change (IPCC) has provided periodic assessments of the state of knowledge on climate change for 30 years. While these assessments have been central to the making of international climate policy, their relevance has been questioned in the post-Paris era. Can the IPCC's global kinds of knowledge match the demands of an increasingly decentralized and polycentric

The role of obstruction in the pathogenesis of acute appendicitis was studied by measuring the pressure in the appendix perioperatively in 24 patients operated on with an appendectomy because of suspected acute appendicitis. The technique used involved inserting a fine needle through the apex into the appendix lumen and measuring the hydrostatic pressure required to inject saline solution. In thre

From the results of the study presented, it can be concluded that, in a group of patients not using contraceptive pills, a significant difference is noted in the frequency of acute appendicitis and the number of appendectomies performed in the different phases of the menstrual cycle. This difference almost disappears in the group of patients using the contraceptive pill. These results suggest that

Six patients who developed acute appendicitis after surgical operations (cholecystectomy, choledocholithotomy, sigmoid resection, osteosynthesis of a hip fracture, abdomino-perineal resection) are described. The symptoms, signs and the results of investigations leading to relaparotomy are summarized. Possible causes of acute appendicitis after operation or trauma (luminal obstruction, bacterial in

The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and