Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an

The dating of terrestrial impact craters and impact glasses that exhibit high degrees of mineralogical complexity can be problematic. However, if the maximum potential of the terrestrial impact crater record is to be realized, accurate and precise ages for crater-forming events are critical. Here we report a high-precision 40Ar/39Ar age for the Dellen impact structure, Sweden. Previous radio-isoto

Parkinson's disease is associated with multiple cognitive impairments and increased risk of dementia, but the extent of these deficits varies widely among patients. The ICICLE-PD study was established to define the characteristics and prevalence of cognitive change soon after diagnosis, in a representative cohort of patients, using a multimodal approach. Specifically, we tested the 'Dual Syndrome'

The role of glial cells in the pathogenesis of many neurodegenerative conditions of the central nervous system (CNS) is now well established (as is discussed in other reviews in this special issue of Frontiers in Neuropharmacology). What is less clear is whether there are changes in these same cells in terms of their behavior and function in response to invasive experimental therapeutic interventi

We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson's Disease Questionnaire. Impairments were most common in

BACKGROUND: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research.OBJECTIVE: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England.METHODS: using a prospective, longitudina

Three independent cases of chronic haemolytic anaemia in Sweden have recently been demonstrated to be due to the unstable haemoglobin variant Hb Koln. The patients, all of whom have partially compensated chronic haemolytic anaemia, presented with aggravated haemolysis during acute infections in childhood. In one case, acute B19 parvovirus infection induced an aplastic crisis. The substitutions all

Vertical InAs/GaSb nanowire TFETs with diameters of 20 nm and 25 nm have been fabricated and characterized. The influence of diameter, gate-placement, and nanowire numbers have been studied. The best device shows a subthreshold swing of 68 mV/dec at VDS = 0.3 V and 26 μA/μm at VDS = 0.3 V and VGS = 0.5 V. It achieves a self-gain larger than 100 with high transconductance efficiency.

The response of organic matter to high-temperature events is important to astrobiology, as it governs the survival of carbon during several processes that may be critical to the origin and spread of life. Impact cratering is a widespread high-temperature process. The behaviour of carbon during impact events is not well understood. But there is the potential to examine other examples of the respons

Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow disease progression (long CAG repeat R6/2 and zQ175-KI). Both were crossed with a transgenic mouse line expressing eGFP in iSPNs. Using the open-fie

A measurement of the ZZ production cross section in the ℓ−ℓ+ℓ′ −ℓ′ + and ℓ−ℓ+νν¯ channels (ℓ = e, μ) in proton-proton collisions at s=8TeV at the Large Hadron Collider at CERN, using data corresponding to an integrated luminosity of 20.3 fb−1 collected by the ATLAS experiment in 2012 is presented. The fiducial cross sections for ZZ → ℓ−ℓ+ℓ′ −ℓ′ + and ZZ→ ℓ−ℓ+νν¯ are measured in selected phase-spac

Associative learning in the cerebellum has previously focused on single movements. In eyeblink conditioning, for instance, a subject learns to blink at the right time in response to a conditional stimulus (CS), such as a tone that is repeatedly followed by an unconditional corneal stimulus (US). During conditioning, the CS and US are transmitted by mossy/parallel fibers and climbing fibers to cere

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk

The research aims to language analysis of the Arab critical speech, which dealt with the study of narrative, in the theoretical and practical side, using pragmatic mechanisms, including holdings of terms, and effective tools in linguistic studies. It’s the starting point for many of the process of modern literary criticism. The study has taken two ways: first, the side of theoretical through summa

A search is presented for new resonances decaying to a W or Z boson and a Higgs boson in the ℓ+ℓ−bb¯, ℓνbb¯, and νν¯bb¯ channels in pp collisions at s=13 TeV with the ATLAS detector at the Large Hadron Collider using a total integrated luminosity of 3.2 fb−1. The search is conducted by looking for a localized excess in the WH/ZH invariant or transverse mass distribution. No significant excess is o