OBJECTIVES: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.METHODS: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82). Efficacy endpoints were assessed in patients without high-titre inhibitors/immune tolerance induction (n = 67).RESULT

BACKGROUND: Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segm

In teaching, analogies can be used to support the introduction of a new concept or idea with reference to a more familiar one. This relies on the learner’s correct understanding of the (supposedly) familiar situation, their identification of the relevant similarities (structural relations) between the two situations, and of the limits of the similarities. Without these, analogies may reinforce or

This study investigates how tourist presence influences word-of-mouth (WOM) and measures whether authenticity significantly mediates presence and WOM in the Augmented Reality (AR) museum tourism experience. The survey data was collected from the AR-presented Palace Museum in China. The study found that presence positively influences tourists’ WOM, and authenticity positively mediated tourist prese

Det har länge varit känt att aktivt lärande, exempelvis i form av att ställa frågor till sig själv på material som ska läras in, är effektivt. Trots detta finns ibland ett motstånd hos såväl lärare som studenter mot nya undervisnings- och examinationsformer (Carpenter, 2023). I testbaserat lärande (eng. retrieval practice) utgår man från att inlärningseffekten förstärks om personen som ska lära ge

The Brazilian Savanna (Cerrado) is the second-largest South American biome that corresponds to almost two-third of the national agricultural production. Extensive agricultural-driven land-use changes have significantly altered the landscape, causing increased soil erosion. Furthermore, projections of climate change effects on the Cerrado raise concerns about the potential exacerbation of soil loss

Selecting the most suitable procurement strategy is crucial to the efficient management of supply chain operations and the prevention of stock shortages. Nevertheless, when dealing with a wide variety of products, this task becomes an intricate challenge. While traditional and advanced procurement tools are available, applying them across such diverse product ranges is often impractical. This rese

Extraterrestrial cratering was a critical component in the evolution of the early Earth, but discovery of very ancient and deeply exhumed impact structures remains elusive, as identification tools are in short supply. The recognition of such structures is hindered by post-cratering geological processes, whereby impact-induced features common in younger, upper-crustal craters may be lost. In this s

Perovskite nanocrystal superlattices are being actively studied after reports have emerged on collective excitonic properties at cryogenic temperatures, where energetic disorder is minimized due to the frozen lattice vibrations. However, an important issue related to structural disorder of superlattices at low temperatures has received little attention to date. In this work, it is shown that CsPbB

1,2-butadiene (1,2-C4H6) is one of four C4H6 isomers that could appear during pyrolysis and oxidation of heavier hydrocarbons and/or contribute to the formation of aromatic species in flames. However, it is seldom included in detailed kinetic mechanisms due to a lack of studies of its combustion characteristics. In this work, laminar burning velocities (LBV) of 1,2-butadiene flames have been measu

Experimental X-ray diffraction data: -- temperature-dependent diffraction patterns (theta:2theta, rocking curves) for C18 and C8 CsPbBr3 nanocrystal superlattice samples;-- room temperature diffraction patterns (theta:2theta, rocking curves) for C6, C8, C10, C12, and C18 CsPbBr3 nanocrystal superlattices;in all files, first column is angle in degrees and the second column is intensity.

Användningen av kontanta pengar minskar och allt fler betalningar görs digitalt. Detta är en global förändring, men den är ovanligt tydlig just i Sverige. Det blir allt vanligare att kollektivtrafiken, affärer och andra serviceställen inte tar emot kontanter som betalningsmedel. Möjligheten att betala räkningar med kontanter över disk är högst begränsad; i stora delar av Sverige finns den inte all

Sammanfattning:Denna berättelse om immunoterapi kombinerad med ultrahypo-fraktionerad strålterapi har sitt ursprung i den kliniska studie som på engelska benämdes "Brain Immune Gene Tumour Therapy" (BRIGTT) som professor Leif G, Salford i Lund initierade strax innan 2000-millienium-skiftet. Ett specifikt tumörvaccin framställdes baserat på tumörceller som han extraherade ur tumörvävnad från den gl

In this study, a report is prepared on significantly low specific contact resistivity of alloyed and non-alloyed ohmic contacts fabricated on an as-grown n+-GaN layer and measured with the transfer length method. A low ρc = 8 × 10−8 Ω cm2 is extracted for the alloyed Ti/Al/Ni/Au, and ρc = 4 × 10−7 Ω cm2 for the unannealed Ti/Pd/Au. To achieve these, a highly doped n+-GaN layer with ND = 1.5 × 1019

Advancing the use of air-sensitive polar organometallic Grignard and organolithium reagents under more environmentally benign conditions, here we report the addition of these reagents to a-b unsaturated ketones and aldehydes using the deep eutetic solvent (DES) choline chloride (ChCl): glycerol (Gly) (1:2), under air. Reactions occur at room temperature within seconds with excellent regioselective

Introduction: The Swedish Sleep Apnea Registry (SESAR) collects clinical data from individual obstructive sleep apnea (OSA) patients since 2010. SESAR has recently been integrated with additional national healthcare data. The current analysis presents the SESAR structure and representative clinical data of a national sleep apnea cohort. Methods: Clinical data from unselected patients with a diagno