Protein drugs, such as monoclonal antibodies, have proved successful in treating cancer and immune system diseases. The structural complexity of these molecules requires careful handling to ensure integrity and stability of the drug. In this study, a failure mode and effects analysis was performed based on a Gemba Walk method in a Swedish University Hospital. The Gemba Walk is focused on pharmacis

Nature-based solutions is a new trend in the area of urban and suburban planning. Thanks to its complex nature, Nature-based solutions provide multiple services on different levels of cities functionality. On the other hand nature-based solutions complexity requires extended knowledge in multiple engineering and societal areas, so the implementation is not straightforward. In recent years, countle

Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes a wide range of airway diseases. NTHi has a plethora of mechanisms to colonize while evading the host immune system for the establishment of infection. We previously showed that the outer membrane protein P5 contributes to bacterial serum resistance by the recruitment of complement regulators. Here, we report

For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. Conventional dendritic cells type 1 (cDC1) are a rare population of professio

By applying the sociological concept of ‘emplacement’, this article analyses the creation of the ‘District of Mutual Respect’ in the old, neglected part of Wrocław (former German Breslau), a city which became Polish and lost its German population due to their forced migration after the Second World War. The District has in the last 20 years been transformed from slum to attractive environment and

Conditional independence is often used as a testable implication of causal models of random variables. In addition, equality constraints have been proposed to distinguish between data-generating mechanisms. We show that one can also find equality constraints in linear Hawkes processes, extending this theory to a class of continuous-time stochastic processes. This is done by proving that Hawkes pro

Background: Patients with heart failure and left bundle branch block (LBBB) may receive cardiac resynchronization therapy (CRT), but current selection criteria are imprecise, and many patients have limited treatment response. Hemodynamic forces (HDF) have been suggested as a marker for CRT response. The aim of this study was therefore to investigate left ventricular (LV) HDF as a predictive marker

Background: Despite advance in care of people with an ostomy, related complications remain prevalent. The objective of this study was to examine short- and long-term healthcare resource utilization and associated costs after ostomy creation. Methods: This observational study was based on retrospectively collected data from national and regional Swedish registries. The population consisted of peopl

Characterising the stop/start walking process of individuals in a crowded and congested space is an important consideration in modelling pedestrian movement. However, the reaction of pedestrians to speed changes, especially to the person in front, has not been fully characterised nor quantified for full adoption in computer models. This study, therefore, explored the different phases of the stop/s

Global climate change has increasing effects on mental health and well-being (e.g., in the form of climate anxiety), both through direct exposure to its consequences (e.g., extreme weather) and through indirect exposure (i.e., the social representation or appraisal of climate change without direct contact to its physical consequences). To help people cope with distress due to climate anxiety, natu

Global climate change has increasing detrimental effects on mental health (e.g., in the form of climate anxiety), both through direct exposure to its consequences (e.g., extreme weather) and through indirect exposure (i.e., the social representation of climate change without direct contact to its physical consequences). To help people cope with the anxious response, nature connectedness is suggest

The increased risk of flooding due to global warming and subsequent heavy rainfall events in the Nordic-Baltic region, call for recommendations directed at long-term planning. One example of such recommendations are climate change allowances. These are often based on expected changes in design precipitation as given by climate model simulations, and are used as a buffer on top of current design va

Since its global invasion in 2019, COVID-19 has affected several aspects of patients’ lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consis

The water sector could play a major role towards a Net Zero greenhouse gas (GHG) future if Scope 3 emissions were embraced and operationalised. Significant opportunities and challenges exist in tackling Scope 3 emissions including those associated with customer hot water use. Present GHG emission reduction practices predominantly focus on Scope 1 “within utility” and Scope 2 “purchased energy” emi

Background: Women with breast cancer have different chances of surviving their disease, depending on where they live. Variations in survival may stem from unequal access to prompt diagnosis, treatment and care. Implementation of the right to health may help remedy such inequalities. The right to health is enshrined in international human rights law, notably Article 12 of the International Covenant

Background: Benign peripheral nerve tumours consist of different types, most commonly Schwannomas. Preoperative Magnetic Resonance Imaging (MRI) is commonly performed before surgery and Pathoanatomical Diagnosis (PAD) confirms the diagnosis. Our aims were to study the utility of MRI and the relation between tumour size and symptoms. Methods: Retrospectively, patients, surgically treated for benign

European forests are among the most extensively studied ecosystems in the world, yet there are still debates about their recent dynamics. We modeled the changes in tree canopy height across Europe from 2001 to 2021 using the multidecadal spectral data from the Landsat archive and calibration data from Airborne Laser Scanning (ALS) and spaceborne Global Ecosystem Dynamics Investigation (GEDI) lidar

Objectives: To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D) (control group). Background: Scientific evidence suggests that the use of diet for individuals with T2D may b

Background: Low back pain (LBP) is the main cause of activity limitation and work absence across the world, leading to a high social and economic burden for individuals, families, the labour market and society. The overall aim of this multicentre study is to test the usability, acceptability and feasibility of an evidence-based, digital education programme for people living and working with persis