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Genetic profiles distinguish different types of hereditary ovarian cancer.

Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide arr

Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden.

Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and results Data from the Swedish Multigeneration Register for subjects aged 0-76 years old for the period 1964-2008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two

Reduced impact of induced gate noise on inductively degenerated LNAs in deep submicron CMOS technologies

Designers of radio-frequency inductively-degenerated CMOS low-noise-amplifiers have usually not followed the guidelines for achieving minimum noise figure. Nonetheless, state-of-the- art implementations display noise figure values very close to the theoretical minimum. In this paper, we point out that this is due to the effect of the parasitic overlap capacitances in the MOS device. In particular,

Tidiga nordiska prepositioner. Härkomst och uppkomst.

Prepositions already formed a grammatical category in the Common German language. New Scandinavian pepositions were established during the preliterary and the early literary periods. In this paper it is demonstraed that most of them were grammaticalizations of prepositional phrases or adverbs linked to a noun by an established preposition. The genesis of these new prepositions is investigated sema

Kristen och postkristen teologi - en lägesrapport

Artikeln är en kritisk diskussion av Martinson, Sigurdson, Svenungsson, "Systematisk teologi - en introduktion" 2007 och av Mattias Martinson, "Postkristen teologi - experiment och tydningsförsök" 2007.

Paroxysmal nocturnal haemoglobinuria at Oslo University Hospital 2000-2010.

BACKGROUND Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematological disease characterised by chronic haemolysis, pancytopenia and venous thrombosis. The condition is attributable to a lack of control of complement attack on erythrocytes, thrombocytes and leukocytes, and can be diagnosed by means of flow cytometry. In this quality assurance study, we have reviewed information from the me

Changing Lowland Permafrost in Northern Sweden: Multiple Drivers of Past and Future Trends

Climate warming is more pronounced in the Arctic than in other parts of the world. This warming affects the terrestrial cryosphere including permafrost with consequences ranging from societal impacts to changes in hydrology and feedbacks in the climate system such as those imposed by changing greenhouse gas exchanges. Permafrost dynamics in a marginal zone for its very existence is in this context

Human cerebral blood volume (CBV) measured by dynamic susceptibility contrast MRI and 99mTc-RBC SPECT.

BACKGROUND: Patients with elevated intracranial pressure risk compromising their cerebral blood flow, resulting in ischemia. Lowering of the raised intracranial pressure, is therefore, mandatory. Reduction of the cerebral blood volume (CBV) might be target. In finding ways to do so, one has to be able to measure CBV. Measurement of CBV is, however, difficult. Radio(99mTc-)labeled erythrocytes (99m

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis is characterized by the accumulation of fibroblasts/myofibroblasts and aberrant remodeling of the lung parenchyma. However, the sources of fibroblasts in IPF lungs are unclear. Fibrocytes are circulating progenitors of fibroblasts implicated in wound healing and fibrosis. In this study we evaluated evidence for the presence of fibrocytes in the lung of patients with i