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3-Substituted indoles and their analogues - hetero condensed pyrroles (hetero-indoles) - have been synthesised by two different palladium-catalysed reactions: a) A series of 2-silylated 3-substituted (hetero-)indoles have been prepared by palladium-catalysed coupling between o-iodo(het)arylamines and silyl substituted internal acetylenes. The outcome of the reaction was found to depend on the typ
Foreign entry mode choices are decisions of paramount importance for the long-term survival and growth of companies that are in a process of rapid international expansion. In this article we seek to understand the foreign market channel strategies of Born Globals. We examine whether these companies develop a similar strategy regarding foreign entry mode choices and if their market channel strategi
In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. When a lead is found, structurally similar compounds with modified functional groups a
Technology change will have a central role in achieving a sustainable energy system. This calls for methods of analysing the dynamics of energy systems in view of technology change and policy instruments for effecting and accelerating technology change. In this thesis, such methods have been developed, applied, and assessed. Two types of methods have been considered, methods of analysing and proje
This chapter makes use of two data sources, terminological schemas for wine descriptions and actual wine reviews, for the investigation of how experiences of sensory perceptions of vision, smell, taste and touch are described. In spite of all the great challenges involved in describing perceptions, professional wine reviewers are expected to be able to give an understandable account of their exper
Cloud applications are often subject to unexpected events like flash crowds and hardware failures. Without a predictable behaviour, users may abandon an unresponsive application. This problem has been partially solved on two separate fronts: first, by adding a self-adaptive feature called brownout inside cloud applications to bound response times by modulating user experience, and, second, by intr
Data-model comparisons are a useful approach to elucidating the relative influence of past climate change on vegetation dynamics over various spatial global, regional, stand) and temporal (historical, geological) scales. Comparisons between changes in tree species abundance reconstructed from pollen and simulated from a forest gap model, for example, indicate that based solely on climate change ov
