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BACKGROUND: We sought to identify potential clinical variables associated with outcomes after radium-223 therapy in routine practice. METHODS: Consecutive non-trial mCRPC patients who received ≥1 dose of radium dichloride-223 at four academic and one community urology-specific cancer centers from May 2013 to June 2014 were retrospectively identified. Association of baseline and on-therapy clinical

Varje cell har ett membran som skapar en gräns mot omvärlden och skyddarcellen. Men cellen måste alltjämt utbyta viktiga molekyler med omvärlden för attöverleva. Därför finns specialiserade proteiner, som sitter i membranen och utgörportar i denna barriär. Denna avhandling fokuserar på två membranproteiner, enprotonpump och en jonkanal.Varje dag i våra liv använder vi hjärnan, muskler och hjärtat.NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. In the hydrophilic domain electrons from NADH oxidation are transported via a wire of iron-sulfur

Over the past decade, the advances in grating-based soft X-ray spectrometers have revolutionizedthe soft X-ray spectroscopies in materials research. However, these novel spectrometers are mostlydedicated designs, which cannot be easily adopted for applications with diverging demands. Here wepresent a versatile spectrometer design concept based on the Hettrick-Underwood optical scheme thatuses modu

Det finns i Sverige en allt tydligare politisk vilja att katalysera digitalisering- en av offentlig sektor, inklusive det kommunala sociala arbetet. Samtidigt pågår också en omfattande digitalisering av det svenska samhället överlag som det kommunala sociala arbetet har att hantera både på organisations-, handläggar- såväl som brukarnivå. Men hur ser det forskningsbaserade kunskapsläget ut?Vi redo

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the a

Nature is perceived and valued in starkly different and often conflicting ways. This paper presents the rationale for the inclusive valuation of nature's contributions to people (NCP) in decision making, as well as broad methodological steps for doing so. While developed within the context of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES), this approach is more widel

Mexico, the second largest economy in Latin America, has almost eradicated extreme poverty according to the Millennium Development Goals; however, official statistics show that by national standards poverty levels are still quite high, reaching up to half its population. This paper looks into how the determinants of poverty in Mexico have evolved after the last major economic crisis the country ex