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Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine beta 145

Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. The aim of this study was to use electron paramagnetic resonance (EPR) spectroscopy, stopped flow opt

Techno-economic evaluation of a two-step biological process for hydrogen production.

An integrated biological process for the production of hydrogen based on thermophilic and photo-heterotrophic fermentation was evaluated from a technical and economic standpoint. Besides the two fermentation steps the process also includes pretreatment of the raw material (potato steam peels) and purification of hydrogen using amine absorption. The study aimed neither at determining the absolute c

Democracy beyond the nation state? Transnational actors and global governance

This is an outline of a new joint Lund-Stockholm six-year research program funded by the Riksbankens Jubileumsfond, addressing three themes: (1) transnational actors and the democratization of international institutions, (2) democracy and public-private partnerships in global governance, and (3) the democratic credentials of transnational actors.

High-k dielectrics on (100) and (110) n-InAs: Physical and electrical characterizations

Two high-k dielectric materials (Al2O3 and HfO2) were deposited on n-type (100) and (110) InAs surface orientations to investigate physical properties of the oxide/semiconductor interfaces and the interface trap density (D-it). X-ray photoelectron spectroscopy analyses (XPS) for native oxides of (100) and (110) as-grown n-InAs epi wafers show an increase in As-oxide on the (100) surface and an inc

The cerebellar microcircuit as an adaptive filter: experimental and computational evidence

Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-te

On the complexity of column generation in survivable network design with path-based survivability mechanisms

This survey concerns optimization problems arising in the design of survivable communication networks. It turns out that such problems can be modeled in a natural way as non-compact linear programming formulations based on multicommodity flow network models. These non-compact formulations involve an exponential number of path flow variables, and therefore require column generation to be solved to

Flux analysis of the Lactobacillus reuteri propanediol-utilization pathway for production of 3-hydroxypropionaldehyde, 3-hydroxypropionic acid and 1,3-propanediol from glycerol

Background Lactobacillus reuteri converts glycerol to 3-hydroxypropionic acid (3HP) and 1,3-propanediol (1,3PDO) via 3-hydroxypropionaldehyde (3HPA) as an intermediate using enzymes encoded in its propanediol-utilization (pdu) operon. Since 3HP, 1,3PDO and 3HPA are important building blocks for the bio-based chemical industry, L. reuteri can be an attractive candidate for their production. However

Coastal cliffs on islands as foraging habitat for bats

Small islands usually show simplified ecosystems with limited availability of suitable foraging habitats for bats, thus habitat selection on islands may differ compared to the mainland. Habitats that are marginal on the mainland may be important on islands. The island of Capri consists, to a large extent, of steep limestone cliffs and Mediterranean shrubland, with virtually no forests or other hab

Autoignition of Dimethyl Ether and Air in an Optical Flow-Reactor

Autoignition of dimethyl ether in air was studied in a turbulent flow-reactor with optical access, at conditions relevant to micro gas turbine combustors. The ignition process was visualized using OH*-chemiluminescence imaging, showing the formation of multiple autoignition kernels along the central axis of the reactor. Ignition delays in the range of tau = 112-310 ms were measured at temperatures

No title

Review of Owe Ronström, “Kulturarvspolitik. Visby från sliten småstad till medeltidsikon” (Stockholm 2008).

Downsizing: Personnel Reductions at the Swedish Tobacco Monopoly, 1915-1939

Downsizing is a phenomenon that remarkably seldom has been the subject of historical inquiry. This study investigates how a state-owned enterprise, the Swedish Tobacco Monopoly, reduced its labour inputs because of changed consumer preferences and mechanization in the 1920s and 1930s. By combining qualitative and quantitative evidence, the study addresses questions about the ways of achieving redu

SPICE: Scalable P2P implicit group messaging

Implicit group messaging (IGM) is a decoupled messaging paradigm for connecting content publishers and consumers over the Internet. Unlike traditional multicast or publish/subscribe messaging, IGM delivers content to “implicit groups” of consumers with characteristics specified by the publisher at the time of publication. IGM systems must support thousands of users and an infinite number of implic

Soil disturbance as a grassland restoration measure-effects on plant species composition and plant functional traits.

Soil disturbance is recognized as an important driver of biodiversity in dry grasslands, and can therefore be implemented as a restoration measure. However, because community re-assembly following disturbance includes stochastic processes, a focus only on species richness or establishment success of particular species will not inform on how plant communities respond ecologically to disturbance. We

Vision and air flow combine to streamline flying honeybees

Insects face the challenge of integrating multi-sensory information to control their flight. Here we study a 'streamlining' response in honeybees, whereby honeybees raise their abdomen to reduce drag. We find that this response, which was recently reported to be mediated by optic flow, is also strongly modulated by the presence of air flow simulating a head wind. The Johnston's organs in the anten

Temporal properties of the lens eyes of the box jellyfish Tripedalia cystophora.

Box jellyfish (Cubomedusae) are visually orientating animals which posses a total of 24 eyes of 4 morphological types; 2 pigment cup eyes (pit eye and slit eye) and 2 lens eyes [upper lens-eye (ule) and lower lens-eye (lle)]. In this study, we use electroretinograms (ERGs) to explore temporal properties of the two lens eyes. We find that the ERG of both lens eyes are complex and using sinusoidal f

Benchmark dose for cadmium-induced osteoporosis in women

We applied a hybrid approach to estimate the benchmark dose (BMD) and the lower 95% confidence limit (BMDL) for cadmium-induced bone effects in a population with low environmental exposure. Morning urine samples were collected by 794 Swedish women, aged 53-64 years, participating in a population-based study We measured urinary cadmium (U-Cd), a marker of long-term exposure, and bone mineral densit