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Targeted mass spectrometry analysis of neutrophil-derived proteins released during sepsis progression.

Early diagnosis of severe infectious diseases is essential for timely implementation of lifesaving therapies. In a search for novel biomarkers in sepsis diagnosis we focused on polymorphonuclear neutrophils (PMNs). Notably, PMNs have their protein cargo readily stored in granules and following systemic stimulation an immediate increase of neutrophil-borne proteins can be observed into the circulat

Subfossil Cladocera in relation to contemporary environmental variables in 54 Pan-European lakes

P>1. Changes in cladoceran subfossils in the surface sediments of 54 shallow lakes were studied along a European latitude gradient (36-68 degrees N). Multivariate methods, such as regression trees and ordination, were applied to explore the relationships between cladoceran taxa distribution and contemporary environmental variables, with special focus on the impact of climate. 2. Multivariate regre

Disgust Predicts Non-consequentialistic Moral Attitudes

237 Japanese university-students read nine moral stories based on three moral aspects (absolute rules, absolute loyalty and retributive punishment) and rated which of two endings (one typically consequentialistic and one typically non-consequentialistic) they believed to be morally preferable. Participants also rated themselves on several personality-variables. Disgust-sensitivity, but not cogniti

Analysis of subsurface microstructure and residual stresses in machined Inconel 718 with PCBN and Al2O3-SiCw tools

Subsurface microstructural alterations and residual stresses caused by machining significantly affect component lifetime and performance by influencing fatigue, creep, and stress corrosion cracking resistance. Assessing the surface quality of a machined part by characterizing subsurface microstructural alterations and residual stresses is essential for ensuring part performance and lifetime in aer

Vibrational vs. electronic coherences in 2D spectrum of molecular systems

Two-dimensional spectroscopy has recently revealed the oscillatory behavior of the excitation dynamics of molecular systems. However, in the majority of cases there is considerable debate over what is actually being observed: excitonic or vibrational wavepacket motion or evidence of quantum transport. In this letter we present a method for distinguishing between vibrational and excitonic wavepacke

Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders.

Evidence has emerged across the past few decades that the lifetime risk of developing morbidities like type 2 diabetes, obesity, and cardiovascular disease may be influenced by exposures that occur in utero and in childhood. Developmental abnormalities are known to occur at various stages in fetal growth. Epidemiological and mechanistic studies have sought to delineate developmental processes and

The Parity of Directed Hamiltonian Cycles

We present a deterministic algorithm that given any directed graph on n vertices computes the parity of its number of Hamiltonian cycles in O(1.619n) time and polynomial space. For bipartite graphs, we give a 1.5npoly(n) expected time algorithm. Our algorithms are based on a new combinatorial formula for the number of Hamiltonian cycles modulo a positive integer.

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome

Objective The development of non-Hodgkin's lymphoma (NHL) confers a high risk of mortality in primary Sjogren's syndrome (pSS) patients, but the sensitivity and specificity of proposed lymphoma predictors are insufficient for practical use. The performance of lymphoid organisation in the form of germinal centre (GC)-like lesions was evaluated in labial salivary gland biopsies taken at pSS diagnosi

Strategies and Policies for the Bioeconomy and Bio-based Economy: An Analysis of Official National Approaches

The onset of formulating strategies and policies regarding the bioeconomy can be, at least partly, attributed to the publication of the bioeconomy policy agenda by the OECD in 2009. The aim of this study is to analyse selected national strategies and policies regarding the development of a bioeconomy and to clarify similarities and differences between them. The article presents a comparative overv

HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007

Background: HTLV-1 is endemic in Guinea-Bissau, and the highest prevalence in the adult population (5.2%) was observed in a rural area, Caio, in 1990. HIV-1 and HIV-2 are both prevalent in this area as well. Cross-sectional associations have been reported for HTLV-1 with HIV infection, but the trends in prevalence of HTLV-1 and HIV associations are largely unknown, especially in Sub Saharan Africa

Immigrants’ Returns to Schooling in Sweden

The aim of this paper is to find out if the returns to immigrants’ schooling are lower than the returns to natives’ schooling. In addition the paper tries to establish whether immigrants who invest in different amounts of Swedish education also differ in their returns to schooling. For immigrants arriving in Sweden as adults, the returns to schooling are on average one log point lower than for nat

Meat consumption and prospective weight change in participants of the EPIC-PANACEA study

Background: Meat intake may be related to weight gain because of its high energy and fat content. Some observational studies have shown that meat consumption is positively associated with weight gain, but intervention studies have shown mixed results. Objective: Our objective was to assess the association between consumption of total meat, red meat, poultry, and processed meat and weight gain afte