Three-dimensional compaction simulations of geometries with circular and quadratic cross-sections are reported using dilatant viscoplastic material models representing a ductile steel powder. The simulations are compared with experiments using in situ measurements of the wall-tractions within the die. Two different porous viscoplastic material models have been used: the combined Fleck-Kuhn-MeMeeki

Although an autonomous mobile ad hoc network (MANET) is useful in many scenarios, a MANET connected to the Internet is more desirable. This interconnection is achieved by using gateways, which act as bridges between a MANET and the Internet. Before a mobile node can communicate with an Internet host it needs to find a route to a gateway. Thus, a gateway discovery mechanism is required. In this pap

A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positio

A method for calculating the wave load induced fatigue damage accumulated by a vessel sailing along the North Atlantic route (NAr) is presented. This method is based on the Palmgren-Miner additive rule and the rainflow cycle (RFC) count. For simplicity, the load the vessel experiences is assumed to be proportional to the encountered significant wave height process, H-s. The asymptotically normal c

We examine the formation of vortices in a one- and two-component gas of bosonic atoms in a harmonic trap that is set rotating. Both the mean-field Gross-Pitaevskii approach, and the numerical diagonalization method are employed. For a two-component Bose gas, we show that beside the well-known coreless vortices of single quantization, the interatomic interactions between the two species may lead to

Background: Human studies assessing thyroid hormone metabolism in relation to brain monoaminergic activity in vivo are scarce. The few studies that do exist suggest significant associations between thyroid function and monoaminergic activity, but the cause-and-effect relationships are far from elucidated. Methods: We simultaneously collected cerebrospinal fluid (CSF) and serum samples from 35 pati

The low-energy region of the intermolecular potential energy hypersurface (PES) of the ammonia dimer was studied at the level of second-order Moller-Plesset perturbation theory (MP2) using a very large basis set. Individual minima were located on the PES employing the counterpoise (CP) correction to account for the basis set superposition error (BSSE). Apart from these canonical MP2 calculations l

Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two

We derive explicit semiclassical quantisation conditions for the Dirac and Pauli equations. We show that the spin degree of freedom yields a contribution which is of the same order of magnitude as the Maslov correction in Einstein-Brillouin-Keller quantisation. In order to obtain this result a generalisation of the notion of integrability for a certain skew product flow of classical translational

Motor dysfunctions in Parkinson's disease are considered to be primarily due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Pharmacological therapies based on the principle of dopamine replacement are extremely valuable, but suffer from two main drawbacks: troubling side effects (e.g. dyskinesia) and loss of efficacy with disease progression. Transplantation of

The present study describes and compares quality of life (QoL) and factors which predict QoL among people aged 75 years and over who receive help with activities of daily living (ADLs) from formal and/or informal helpers. The subjects were living at home or in special accommodation in Sweden. A postal questionnaire was sent to a randomly selected and age-stratified sample of 8500 people. The respo

We discuss four variants of the graph colouring problem, and present algorithms for solving them. The problems are k-COLOURABILITY, MAX IND k-COL, MAX VAL k-COL, and, finally, MAX k-COL, which is the unweighted case of the MAX k-CUT problem. The algorithms are based on the idea of partitioning the domain of the problems into disjoint subsets, and then considering all possible instances were the va

This study reports effects on soil solution chemistry and plant uptake of 55 elements (Ag, Al, As, B, Ba, Be, Bi, Br, Ca, Cd, Ce, Co, Cr, Cs, Cu, Dy, Er, Eu, Fe, Gd, Ge, Hf, Hg, Ho, K, La, Li, Lu, Mg, Mn, Mo, Na, Nb, Nd, Ni, P, Pb, Pr, Rb, S, Sb, Sc, Se, Si, Sm, Sr, Tb, Th, Tl, U, V, W, Y, Yb, Zn, Zr) by raising the pH using addition of fine-grained precipitated calcium carbonate at 20 rates (yiel

The aim of this study was to characterize the reversible cerebral uptake of morphine in the pig by measuring the changing arterio-venous plasma concentration gradient over the brain. Seven pigs were anaesthetized by continuous infusions of ketamine and pancuronium and ventilated with oxygen in nitrous oxide. During and after 5-min intravenous infusions of morphine hydrochloride, blood samples were

Background: The GOLD classification of COPD severity introduces a stage 0 ( at risk) comprising individuals with productive cough and normal lung function. The aims of this study were to investigate total mortality risks in GOLD stages 0 - 4 with special focus on stage 0, and furthermore to assess the influence of symptoms of chronic bronchitis on mortality risks in GOLD stages 1 - 4. Method: Betw

Clear cell renal cell carcinoma (ccRCC) is the most common type of cancer in the adult kidney, and the prognosis of metastatic ccRCC remains poor with high mortality. In ccRCC, microRNAs (miRs) differentially expressed in tumour tissue have been identified and have been proposed to predict prognosis. The purpose of this study was to evaluate candidate miR markers identified from analysis of The Ca

Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-se