Background: An increasing number of neo-adjuvant breast cancer studies are being conducted and a novel model for tumor biological studies, the "window-of-opportunity" model, has revealed several advantages. Change in tumor cell proliferation, estimated by Ki67-expression in pre-therapeutic core biopsies versus post-therapeutic surgical samples is often the primary end-point. The aim of the present

The interaction mechanism of a novel amphiphilic antimicrobial peptide dendrimer, BALY, with model lipid bilayers was explored through a combination of neutron reflection and molecular dynamics simulations. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phos-phocholine (DPPC) lipid bilayers were examined at room temperature to extract information on the in

Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese po

The concept of “style of thought” or Denkstil is today probably primarily associated with the Polish microbiologist and philosopher of science Ludwik Fleck and his writings from the 1930s. It was however used quite extensively already by Karl Mannheim in his writings on the sociology of knowledge from the 1920s. Quite interestingly, the concept of style of thought was also used twice by Rudolf Car

The reliability of the newly constructed Moral Attitude Questionnaire (MAQ) was tested in this Pilot study. MAQ aims to assess individual and cultural differences in moral attitudes and expected behavior on a broad scale, contrasting typically consequentialistic attitudes with typically non-consequentialistic attitudes congruent with common-sense moral. Five representative categories with five sto

Measurements with unknown time delays are common in different applications such as microphone array, radio antenna array calibration, where the sources (e.g. sounds) are transmitted in unknown time instants. In this paper, we present a method for estimating unknown time delays from Time-Difference-of-Arrival (TDOA) measurements. We propose a novel rank constraint on a matrix depending on the measu

There has been considerable interest in the directionality of resource specialisation during the diversification of lineages. We developed a quantitative method to investigate habitat specialisation in a radiation of New Zealand triplefin fishes, as habitat use appears to be an important axis of diversification in this marine group. The degree of specialisation in 15 species was calculated by comp

Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls)

This is a review of a book on Ephrem the Syrian published in Danish and containing one of the biographies of the Syrian saint translated into Danish.

The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of similar evidence based position papers published in 2005 and 2007. The document contains chapters on definitions and classification, we now also propose definitions for 'difficult to treat' rhinosinusitis, control of disease and better definitions for rhinosinusitis in children. More emphasis is placed on the diag

Objectives. To study the correlation between Sunnybrook and House-Brackmann facial grading systems at different time points during the course of peripheral facial palsy. Study Design. Prospective multicenter trial. Setting. Seventeen otorhinolaryngological centers. Subjects and Methods. Data are part of the Scandinavian Bell's palsy study. The facial function of 1920 patients with peripheral facia

I artikeln analyseras maktrelationen mellan socialarbetare och deltagare i ett kommunalt aktiveringsprojekt för arbetslösa. Socialarbetarna ska samtidigt både stödja och kontrollera de arbetslösa, vilket skapar en relation mellan representanterna för välfärdsstatens hjälpverksamhet och deras klienter. Analysen utgår från den franske idéhistorikern och filosofen Michels Foucaults teoribildning om p

Context. The Bulge is the least understood major stellar population of the Milky Way. Most of what we know about the formation and evolution of the Bulge comes from bright giant stars. The underlying assumption that giants represent all the stars, and accurately trace the chemical evolution of a stellar population, is under debate. In particular, recent observations of a few microlensed dwarf star

Scatterhoarding birds that cache food items have become an important model system for the study of spatial memory and its correlates in the brain. In particular, it has been suggested that through adaptive specialization, species that cache food have better spatial memory and a relatively larger hippocampus than their non-caching relatives. Critics of this approach, dubbed neuroecology, maintain t