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Severe Covid-19 has a high mortality rate. Vital organ dysfunction results from pathophysiological self-amplifying loops of innate immunological hyperactivation, cytokine release, complement deposition, endothelial damage, and macro- and microvascular thromboembolism. Resulting alveolar exudation and pulmonary capillary thromboembolism lead to ventilation-perfusion mismatch, considered to be a pri

Aims: Certain autoimmune diseases (ADs), such as Crohn's disease and celiac diseases, have been linked to acute cardiovascular disorders. We examined whether there is an association between 43 different ADs and risk of subsequent hospitalization and mortality of cardiomyopathy in a nationwide follow-up study in Sweden. Methods and results: All individuals in Sweden hospitalized with a main diagnos

Quantum dots (QDs) form a promising family of nanomaterials for various applications in optoelectronics. Understanding the details of the excited-state dynamics in QDs is vital for optimizing their function. We apply two-color 2D electronic spectroscopy to investigate CdSe QDs at 77 K within a broad spectral range. Analysis of the electronic dynamics during the population time allows us to identif

This chapter provides a historical overview of the development of Middle East diaspora studies and outlines the main themes within the field. Following the overview, the chapter introduces the edited volume by outlining the main arguments of each of the contributions and the ways the different chapters connect to a larger thematic argument within the field of Middle East diaspora studies.

This thesis investigates ultracold bosonic systems using an extended mean-field formalism with a focus on their superfluid and supersolid properties. The dissertation comprises five chapters and four articles, where the chapters provide some background to the research put forward in articles.Paper I demonstrates the existence of multiple singly-quantized vortices in two-dimensional droplets made o

Changes in nutrient bioavailability due to increased loading of dissolved organic matter (DOM) may impact boreal freshwaters. Yet, the relative bioavailability of carbon (C), nitrogen (N), and phosphorus (P) associated with terrestrial DOM remains poorly understood. We applied short-term bioassays with natural bacterial inocula to determine seasonal variation in bioavailable organic nutrient pools

Since 2011, Moroccan civil society actors have experienced an important political opening that has allowed them to play a much more direct and influential role in the process of policy-making. The National Dialogue that has taken place between the government and civil society in the writing of different pieces of legislation represents a demonstrable step towards increased participation and legiti

The concept of ‘patient involvement’ is highlighted in healthcare. However, hindrances can prevent its implementation. This article explored how ‘patient involvement’ is understood and on what ideas this understanding is based through a critical textual analysis of the European document on patient involvement in health systems using a Fairclough-inspired critical discourse analysis. The findings s

Presentation av ett rättssociologiskt forskningsprojekt som replikerar en rättssociologisk undersökning om det allmänna rättsmedvetandet och brottsskadeersättningen. Att projektet är en ”replika” innebär att syftet har varit att göra en uppföljning av ett ursprungligt forskningsprojekt som i det aktuella fallet utgörs av de enkätundersökningar som presterades i avhandlingen ”Kränkning och upprätte

BACKGROUND: The Flow-Self Organizing Maps (FlowSOM) artificial intelligence (AI) program, available within the Bioconductor open-source R-project, allows for an unsupervised visualization and interpretation of multiparameter flow cytometry (MFC) data.METHODS: Applied to a reference merged file from 11 normal bone marrows (BM) analyzed with an MFC panel targeting erythropoiesis, FlowSOM allowed to

Aims: It is increasingly recognized that tools are required for assessing and benchmarking quality of care in order to improve it. The European Society of Cardiology (ESC) is developing a suite of quality indicators (QIs) to evaluate cardiovascular care and support the delivery of evidence-based care. This paper describes the methodology used for their development. Methods and results: We propose

Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). Genetic variation in complement factor I (CFI) has been identified in both AMD and aHUS, with more than half of these variants leading to reduced FI

Exaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs) are reported in systemic sclerosis (SSc) but its involvement in SSc pathogenesis is not clear. In the present study we assessed markers of neutrophil activation and NET formation in SSc patients in relation to markers of inflammation and disease phenotype. Factors promoting neutrophil activation in SSc remain

Background and purpose - Hip surveillance in children with cerebral palsy (CP) includes repeated radiographic hip examinations and measurements of the hip migration percentage (MP) to identify hips in need of surgery early, to prevent dislocation with the fewest number of radiographic examinations possible. We analyzed the early development of the MP in hips operated on to prevent hip dislocation