Aims: Most benign bladder pathologies are associated with an increase of extracellular matrix (ECM—fibrosis) and may progress from formation of stiffer matrix to a more compliant structure. The aims were to summarize current knowledge of the origins of bladder fibrosis and consequences in bladder function. Methods: A meeting at the International Consultation on Incontinence Research Society 2017 c

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to Alzheimer’s disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor state for AD. Here we have shown that S100A9-driven amyloid-neuroinflammatory cascade was initiated in TBI and may serve as a mechanistic link between TBI and AD. By analyzing the TBI and AD human brain tissues, we demonstrated t

Abstract in Undetermined Under närmare ett decennium har jag följt behandlingen av AstraZenecas numera fastslagna överträdelser av konkurrensrätten. Den fällande domen är kanske inte alldeles oväntad, även om det funnits anledning att diskutera olika frågeställningar. När jag ser tillbaka på de samlade bidragen slår det mig att min främsta invändning är att myndigheterna så enögt främjar den gener

This paper uses logbook data from Swedish Baltic Sea cod trawlers to investigate the revenue target hypothesis. Incomes from fishing can be highly variable and difficult to predict and it is possible that fishermen set specific revenue targets for their fishing trips to simplify decision making. In this paper a discrete choice stopping model is used where the fishermen must decide to stop or conti

The aim of this paper is to combine remote sensing data with geo-coded household survey data in order to measure the impact of different socio-economic and biophysical factors on maize yields. We use multilevel linear regression to model village mean maize yield per year as a function of NDVI, commercialization, pluriactivity and distance to market. We draw on seven years of panel data on African

Fishing access agreements have been widely criticized but there is little quantitative evidence of their effects on the economies of developing countries. The aim of this paper is to investigate the influence of the European Union’s fishing access agreements on 15 African countries’ fish exports to the OECD. More specifically, we investigate the effects on the extensive and intensive margins of tr

The NDVI is a remotely sensed vegetation index that is frequently used in ecological studies. There is, however, a lack of studies that evaluate the ability of the NDVI to detect fine-scale variation in grassland plant community composition and species richness. Ellenberg indicators characterize the environmental preferences of plant species—and community-mean Ellenberg values have been used to ex

The shaping of a city and its future relates to official decisions made in city planning meetings, where daily planning matters and decision-making processes adapt to changing societal circumstances. The interest of this research lies in how planning is officially established, managed and practiced in the setting of a Jordanian city, and its local districts. This interest leads the research to obs

Laurie Cohen and Joanne Duberley describe their use of an unconventional data source-a radio programme-to study celebrity careers. This source also includes music, which evokes memories, and elicits emotions not readily captured in conventional interviews. They used the archives of the BBC Radio 4 programme Desert Island Discs to study the careers of well-known research scientists. The programme's

The presence of contralateral tactile input can profoundly affect ipsilateral tactile perception, and unilateral stroke in somatosensory areas can result in bilateral tactile deficits, suggesting that bilateral tactile integration is an important part of brain function. Although previous studies have shown that bilateral tactile inputs exist and that there are neural interactions between inputs fr

The choice of hyperparameter(s) notably affects the support recovery in LASSO-like sparse regression problems, acting as an implicit model order selection. Parameters are typically selected using cross-validation or various ad hoc approaches. These often overestimates the resulting model order, aiming to minimize the prediction error rather than maximizing the support recovery. In this work, we pr

Massive multiple-input multiple-output (MIMO) is one of the key candidates for the upcoming 5G wireless generation. It offers a multitude of advantages over traditional techniques, such as reduced latency, reduced interference among user equipments (UEs) and increased spectrum and energy efficiencies. However, to verify the theoretically promised gains in real-life, prototype systems are inevitabl

Much of the current work on third language acquisition focuses on modeling the impact from the speaker’s previous language(s). The Typological Primacy Model (Rothman, 2015), which covers holistic forward transfer at the initial state, and the L2 Status Factor (Bardel and Falk, 2012), which proposes forward transfer from a chronologically true L2, only predict effects on subsequently acquired langu

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are

Context: Both scientific publications and grey literature have widely been employed as sources of empirical evidence in evidence-based software engineering (EBSE). However, there is still a fierce debate about whether or not the pervasive Web content can act as an alternative means to gather evidence for EBSE. Aim: To help ourselves enter this debate, this work aims to obtain some pre-evidence of

A great deal of literature has analyzed the relationship between warfare and state capacity in late-modern and contemporary times. While there is a consensus regarding the significant impact of mass warfare on fiscal expansion during the twentieth century, the interplay between warfare and fiscal capacity in the nineteenth century remains disputed. This paper sheds light on this issue by making us