Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 binds and phosphorylates acinus, an SR protein essential for RNA splicing, and redist

Background: Transanal endorectal one-stage pull-through (TERPT) procedure in children with Hirschsprung’s disease (HD) is frequently used worldwide. In order to give the families realistic expectations and to plan the medical care for the years after TERPT, the long term outcome is of great importance. Aim: To collect information on the long term outcome reported after one stage TERPT procedure fo

We propose a sender-specific blockmodel for network data which utilizes both the group membership and the identities of the vertices. This is accomplished by introducing the edge probabilities $(\theta_{i, v})$ for $1\le i\le c, 1\le v\le n$, where $i$ specifies the group membership of a sending vertex and $v$ specifies the identity of the receiving vertex. In addition, group membership is conside

Recension av Dennis E. Showalter & Harold C. Deutsch (red.), Om Tyskland segrat – 53 alternativa scenarier.

Attention deficit/hyperactivity disorder (ADHD) is characterized by inattention, impulsivity, and motor hyperactivity. Several lines of research support a crucial role for the dopamine transporter (DAT) gene in this psychiatric disease. Consistently, the most commonly prescribed medications in ADHD treatment are stimulant drugs, known to preferentially act on DAT. Recently, a knock-in mouse [DAT-c

This article discusses the political use of the fall of the Roman empire and in particular the way this historical motif has been utilized in environmental debates and in US political culture. It is furthermore argued that the historiography of the fall of the Roman empire bears witness to the ideological and existential contexts of specific explanations to why Rome fell.

This paper investigates algorithmic properties and overall performance of the exact auction algorithm in Demange, Gale and Sotomayor (J. Polit. Economy 94: 863-872, 1986) or DGS for short. This task is achieved by interpreting DGS as a graph and by conducting a large number of computer simulations. The crucial step in DGS is when the auctioneer selects a so-called minimal overdemanded set of items

Quantum dots are model systems for quantum thermoelectric behavior because of their ability to control and measure the effects of electron-energy filtering and quantum confinement on thermoelectric properties. Interestingly, nonlinear thermoelectric properties of such small systems can modify the efficiency of thermoelectric power conversion. Using quantum dots embedded in semiconductor nanowires,

We show that conformational entropies calculated for five proteins and protein-ligand complexes with dihedral-distribution histogramming, the von Mises approach, or quasi-harmonic analysis do not converge to any useful precision even if molecular dynamics (MD) simulations of 380-500 ns length are employed (the uncertainty is 12-89 kJ mol(-1)). To explain this, we suggest a simple protein model inv

Accurate modeling of thermal power plant is very useful as well as difficult. Conventional simulation programs based on heat and mass balances represent plant processes with mathematical equations. These are good for understanding the processes but usually complicated and at times limited with large number of parameters needed. On the other hand, artificial neural network (ANN) models could be dev

Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH) D) levels and cognitive performance in middle-aged and older European men. Methods: This population-based cross-sectional study included 3,369

This study focused on how phosphorus and carbon control pelagic bacteria in lakes over a gradient of dissolved organic carbon (DOC from 6.7 to 29.5 mg C L-1) and phosphorus (P-tot from 5 to 19 mu g L-1). Five oligotrophic lakes in southern Sweden were sampled in late autumn. Phosphate-P and glucose-C alone or in combination (0.01 and 0.3 mg L-1, respectively) was added to 1.0 mu m filtered lake wa

Popular Abstract in Swedish Summary in Swedish Populärvetenskaplig sammanfattning Förhöjt blodtryck, s.k. hypertension, är en folksjukdom i västvärlden och en riskfaktor för hjärtkärlsjukdomar som hjärtinfarkt och stroke (slaganfall). Ca 27 % av den vuxna befolkningen i Sverige beräknas ha hypertension och är lika fördelad mellan män och kvinnor. Salt beräknas bidra till förhöjt blodtryck och kan Abstract The average amount of salt ingested is about 10 grams daily compared to less than one gram in pre-historic life. Salt, althought somewhat debated, is considered a risk factor for elevated blood pressure and end organ damage beyond the blood pressure effect. Thus, salt contributes to the hypertensive phenotype, increase risk of cardiovasvcular disease, deaths and is a great socioeconomic