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Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies

A method of removing radiolabeled monoclonal antibodies (mAbs) from blood using a device external to the body, termed extracorporeal affinity-adsorption (EAA), is being evaluated as a means of decreasing irradiation of noncancerous tissues in therapy protocols. The EAA device uses an avidin column to capture biotinylated-radiolabeled mAbs from circulated blood. In this investigation, three trifunc

Comparison of the 2,2-azinobis-3-ethylbenzotiazoline-6-sulfonic acid (ABTS) and ferric reducing anti-oxidant power (FRAP) methods to asses the total antioxidant capacity in extracts of fruit and vegetables

A comparison was made on the use of two spectrophotometric methods, the ferric reducing antioxidant power (FRAP) method and the 2,2 '-azinobis-3-ethylbenzotiazoline-6-sulfonic acid (ABTS) method, for the measurement of the total antioxidant capacity (TAC) of plant foods. The correlations of TAC measured by the two methods were highly significant in both water-soluble (r(2) = 0.90) and water-insolu

Anticipation requires adaptation

To successfully interact with a dynamic world, our actions must be guided by a continuously changing anticipated future. Such anticipations must be tuned to the processing delays in the nervous system as well as to the slowness of the body, something that requires constant adaptation of the predictive mechanisms, which in turn require that sensory information be processed at different time-scales.

Despite high uptake efficiency, non-mycorrhizal Rumex acetosella increases available phosphorous in the rhizosphere soil, whereas Viscaria vulgaris, Plantago lanceolata and Achillea millefolium does not

The phosphorous (P) uptake efficiency, reduction of the soil extractable P, and the root morphology was determined for the four common grassland species Rumex acetosella, Viscaria vulgaris, Plantago lanceolata and Achillea millefolium in one pot cultivation and one microcosm experiment. Rumex acetosella produced more than tree times as much biomass as each of V. vulgaris, P. lanceolata and A. mill

Urbanicity of place of birth and symptoms of psychosis, depression and anxiety in Uganda

Background The mechanism underlying the association between urban birth/upbringing and increased schizophrenia risk is unknown. This study explored whether an urban effect might be present in a low-income country setting, where the 'urban' environment may have radically different components, for example urban architecture, pollution levels or social cohesion. Aims To investigate the potential asso

Glacial and climate history of the Antarctic Peninsula since the Last Glacial Maximum

During the Last Glacial Maximum (LGM), ice thickened considerably and expanded toward the outer continental shelf around the Antarctic Peninsula. Deglaciation occurred between >14 ka BP and ca. 6 ka BP, when interglacial climate was established in the region. Deglaciation of some local sites was as recent as 4-3 ka BP. After a climate optimum, peaking ca. 4-3 ka BP, a distinct climate cooling occu

Connectivity and performance of science-based firms

This paper addresses whether or not there is a relationship between a young science-based firm's patterns of connections and the associated resource flows, and its performance. Hypotheses derived from the literature are tested in relation to three performance indicators: inventiveness, innovativeness and employment. Analyzing a set of firms in Sweden, Ohio and Massachusetts, working with biocompat

A longitudinal study of material planning applications in manufacturing companies

Purpose-The paper seeks to describe the state-of-the-art, reasons for selecting various material planning methods, and modes of applying methods for initiating inventory replenishment of purchased items. It also identifies trends from 1993 to 2005. Design/methodology/approach-Empirical survey data are collected from Swedish manufacturing companies in 1993, 1999 and 2005. The MRP, re-order point, f

Leukotriene D-4 induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKC delta

The intestinal epithelial barrier, which is regulated by the actin cytoskeleton, exhibits permeability changes during inflammation. Here we show that activation of the CysLT(1) receptor by the inflammatory mediator leukotriene D-4 (LTD4) causes a rapid increase in stress-fibre formation in intestinal epithelial cells. This effect was mimicked by cytotoxic necrotising factor-1 (CNF-1)-induced activ

Maternal smoking and congenital malformations

Since the first report by Simpson (1957) of the association between premature birth and maternal smoking, the research on the consequences of maternal smoking during pregnancy on perinatal outcome has been intense. Even if some of the findings have been contradictory, it is now evident that maternal smoking is associated with pre-term birth and low birth weight, low birth weight for gestational ag

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation

Inflammation is a key pathology in asthma. In the central airways local inflammation leads to irreversible remodeling and airway dysfunction. Complex inflammatory changes also occur in the nose, sinuses, and small airways. In particular, rhinitis and asthma are linked by a common pathogenic process with common inflammatory cells, mediators, and cytokines. Cross-communication between the airways an

Seasonal variation in home-range size, and habitat area requirement of the lesser spotted woodpecker (Dendrocopos minor) in southern Sweden

Seasonal variation in home-range size and habitat area requirement of lesser spotted woodpeckers (Dendrocopos minor) were studied by radio-tracking in southern Sweden for 6 years. Home-range size did not vary between age-groups or sexes, but varied with season and decreased successively from 742 ha in winter (n = 10), 355 ha in early spring (n = 15), 103 ha in late spring (n = 22) to 43 ha during

Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation

Relatively little is known about the cytogenetic features of multiple myeloma (MM) when compared to other hematologic malignancies. The reasons for this are most likely manifold, and include a low mitotic index of the malignant cells and the presence of cytogenetically cryptic abnormalities as well as of complex karyotypes with poor chromosome morphology. In the present study, we have investigated

Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein

Epithelial cells of many mucosal organs have adapted to coexist with microbes and microbial products. In general, most studies suggest that epithelial cells benefit from interactions with commensal microorganisms present at the lumenal surface. However, potentially injurious molecules found in this microenvironment also have the capacity to elicit local inflammatory responses and even systemic dis