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The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, the building blocks for DNA synthesis, and are found in all but a few organisms. RNRs use radical chemistry to catalyze the reduction reaction. Despite RNR having evolved several mechanisms for generation of different kinds of essential radicals across a large evolutionary time frame, this initial r

Two- and three-pion quantum statistics correlations in Pb-Pb collisions at root S-NN=2.76 TeV at the CERN Large Hadron Collider

Correlations induced by quantum statistics are sensitive to the spatiotemporal extent as well as dynamics of particle-emitting sources in heavy-ion collisions. In addition, such correlations can be used to search for the presence of a coherent component of pion production. Two- and three-pion correlations of same and mixed charge are measured at low relative momentum to estimate the coherent fract

Where on earth can animals use a geomagnetic bi-coordinate map for navigation?

Many animal taxa have been shown to possess the ability of true navigation. In this study we investigated the possibilities for geomagnetic bi-coordinate map navigation in different regions of the earth by analysing angular differences between isolines of geomagnetic total intensity and inclination. In no-grid zones where isolines were running almost parallel, efficient geomagnetic bi-coordinate n

Machine Vision for Road Pavement Applications Bitumen Coverage and Grain Size Estimation

In this thesis some research questions regarding durability and quality of roads has been investigated. The questions are analyzed from an image analysis point of view and aims to be a complement to existing methods for analyzing asphalt. One important factor for the durability of the asphalt layer on roads is the affinity between the stones in the asphalt and the binder that holds the stones tog

Motion in Language and Experience : Actual and Non-actual motion in Swedish, French and Thai

This thesis deals with motion in language and non-linguistic experience, distinguishing between actual motion (AM) and non-actual motion (NAM). AM is the experience of continuous change in an object’s position, expressed in sentences such as 'The man runs through the forest' and 'The woman is walking'. NAM refers to dynamic qualities involved in conceiving or perceiving static situations and is ex

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This paper presents diagnostic criteria for Menière's disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. The classification includes 2 c

Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study dem

Radioactivity exploration from the Arctic to the Antarctic. Part 3. The SWEDARP expedition Oct 1988 – April 1989

The Swedish Antarctic Research Expedition named “SWEDARP” was performed during October 1988 through April 1989. The aim of our project was to study the radioactivity in air and water from Gothenburg to the Antarctic. Between Gothenburg and the Equator, the average activity concentration of 7Be in air was 4.3 ± 0.7 mBq/m3. The activity concentration of 7Be in the South Atlantic down to Antarctica v

Overdoses, suicidal behaviour and clinical characteristics in heavy drug users. Studies in the Criminal Justice System.

Background: Substance use disorders and complications, such as drug overdose (OD) and suicide attempt (SA), are common among criminal justice clients. Methods: Since 2001, the Swedish Prison and Probation Service has assessed substance-using clients with the Addiction Severity Index (ASI), a semi-structured instrument widely used to examine substance-related problems in different domains of life.

Using vignette methodology to research the process of breach comparatively

Comparative research related to any aspect of the process of breach in either the pretrial, sentencing or release phases is relatively rare. Comparative studies of decision making in the specific context of breach process are particularly lacking. One reason for the dearth of research in this area is the many challenges presented by comparative research across different jurisdictions. This article

EULAR recommendations for the management of large vessel vasculitis

Objectives: To develop European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis. Methods: An expert group (10 rheumatologists, 3 nephrologists, 2 immunolgists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a systematic literature searc

Differences between body movement adaptation to calf and neck muscle vibratory proprioceptive stimulation

Adaptation is essential in maintaining stability during balance-challenging situations. We studied, ill standing subjects with eyes open and closed, adaptive responses of the anteroposterior head, shoulder, hip and knee movements: gastrocnemius and tibialis anterior EMG activity and anteroposterior body Posture when proprioceptive information from the neck or calf muscles underwent vibratory pertu

Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles

Molecularly imprinted polymers (MIPs) are gaining great interest as tailor-made recognition materials for the development of biomimetic sensors. Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly on transducer surfaces. In this work we functionalized quartz

In vivo Sub-regional dGEMRIC Analysis and Contrast Distribution in Clinical Studies of Human Knee Cartilage

Aims: This work was carried out to investigate whether considering cartilage depth in vivo dGEMRIC would provide additional information on the molecular content and changes in normal and diseased cartilage. Methods: Study I was a longitudinal study on 23 healthy volunteers; Study II was a case-control study on 9 sedentary individuals and 8 elite runners. Study III was a longitudinal study on 30 p

Ömse sidor om vägen : Allén och landskapet i Skåne 1700-1900

This thesis is about avenues (tree-lined roads – in Swedish alléer). Avenues are a characteristic landscape element in many parts of Scania. This is an object created by man with a clear visual effect in the landscape. The avenue is also something which is both nature and culture, a man-made object from nature. The purpose of the thesis is to describe, analyse and discuss the historical geograph