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Selenoprotein P deficiency is associated with higher risk of incident heart failure

AbstractIntroductionSelenium deficiency has been associated with mortality, cardiovascular disease and worsened prognosis in heart failure (HF). In a recent population-based study, high selenium levels were shown to be associated with reduced mortality and reduced incidence of HF, but only in non-smokers. Here, we aimed to examine if selenoprotein P (SELENOP), a main selenium carrier protein, is a

The Baltic Battle of Books : Formation and Relocation of European Libraries in the Confessional Age (c. 1500–c. 1650) and Their Afterlife

This book is about the creation, relocation, and reconstruction of libraries between the late Middle Ages and the Age of Confessionalization, that is, the era of religious division and struggle in Northern Europe following the Reformation and Counter-Reformation in the sixteenth and seventeenth centuries. At the time, different creeds clashed with each other, but it was also a period in which the

Judicial Review in the Digital Era: Safeguarding the Rule of Law Through Added Safeguards?

This article analyses the rule of law in the Digital Single Market with a particular focus on the recent Ligue des droits humains judgment (in case C-817/19), which deals with the PNR Directive (directive (EU) 2016/681). In that judgment, the CJEU essentially imposed additional safeguards on a legislative measure in an attempt to protect fundamental rights and the rule of law, rather than declarin

3d Finite Element Models Reconstructed From 2d Dxa Images Improve Hip Fracture Prediction Compared to Areal Bmd in Mros Sweden Cohort

Bone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have ear

Model ensembles of ecosystem services fill global certainty and capacity gaps

Sustaining ecosystem services (ES) critical to human well-being is hindered by many practitioners lacking access to ES models (“the capacity gap”) or knowledge of the accuracy of available models (“the certainty gap”), especially in the world’s poorer regions. We developed ensembles of multiple models at an unprecedented global scale for five ES of high policy relevance. Ensembles were 2 to 14% mo

Neurotensin Gene rs2234762 C>G Variant Associates with Reduced Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in Overweight/Obese Children

Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. The circulating levels of its precursor, pro-NT, predicts the presence and development of metabolic and cardiovascular dise

Cobalt nanoparticles cause allergic contact dermatitis in humans

Background: Cobalt (Co) causes allergic contact dermatitis (ACD) and the emerging use of Co nanoparticles (CoNPs) warrants gaining further insight into its potential to elicit ACD in sensitized individuals. Objectives: The aims of the study were to clarify to what extent CoNPs may elicit ACD responses in participants with Co contact allergy, and to evaluate whether the nanoparticles cause a distin

Phosphorus regulates ectomycorrhizal fungi biomass production in a Norway spruce forest

Ectomycorrhizal fungi (EMF) are important components of soil microbial communities, and EMF biomass can potentially increase carbon (C) stocks by accumulating in the soils as necromass and producing recalcitrant structures. EMF growth depends on the C allocated belowground by the host trees, and the nutrient limitation on tree growth is expected to influence this allocation. Therefore, studying EM

Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster

Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To va

Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation in Preterm Pigs

Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is associated with postnatal growth restriction and poor neurologic outcomes. It remains unknown whether supplemental IGF-1 may stimulate neurode-velopment in preterm neonates. Using cesarean-delivered preterm pigs as a model of preterm infants, we investi-gated the effects of supplemental IGF-1 on motor function a

A comparison in women with newly diagnosed diabetes between those with and without a history of gestational diabetes : a new perspective

Aims: Previous gestational diabetes mellitus (GDM) entails increased risk of future diabetes. We describe the characteristics of women with previous GDM and compare with no previous GDM from the cohort Diabetes in Kalmar and Kronoberg (DKK) of 1248 adults, 40% women, with new diabetes, and factors affecting age and C-peptide levels at diagnosis of diabetes. Methods: Age-at-diagnosis of diabetes, B

Human Rights as Space-Making : Bodily Performative Activism Against Sexual Violence in Egypt

This article introduces the concept of space-making as a form of human rights activism. To develop the concept, I use the example of contentious street activism against sexual violence in post-2011 Egypt. My research has found that feminist activists utilised human rights as a legal tool for improving legislation and policy and as a linguistic strategy to challenge derogatory discourse. Using huma

Developing an Intervention to Enhance Parental Monitoring in Family Foster Care

Purpose: To fulfill their supervision and counseling responsibilities to foster parents, social workers need an effective way to indirectly monitor foster children's mental health and learning ability within a model of tripartite parenthood. This article describes how we are developing an intervention aimed at enhancing parental monitoring as a protective factor in family foster care. Methods: Foc

Sub-Picosecond Carrier Dynamics Explored using Automated High-Throughput Studies of Doping Inhomogeneity within a Bayesian Framework

Bottom–up production of semiconductor nanomaterials is often accompanied by inhomogeneity resulting in a spread in electronic properties which may be influenced by the nanoparticle geometry, crystal quality, stoichiometry, or doping. Using photoluminescence spectroscopy of a population of more than 11 000 individual zinc-doped gallium arsenide nanowires, inhomogeneity is revealed in, and correlati

Spatially repeatable components from ultrafast ultrasound are associated with motor unit activity in human isometric contractions

Objective. Ultrafast ultrasound (UUS) imaging has been used to detect intramuscular mechanical dynamics associated with single motor units (MUs). Detecting MUs from ultrasound sequences requires decomposing a velocity field into components, each consisting of an image and a signal. These components can be associated with putative MU activity or spurious movements (noise). The differentiation betwe

Effect of docetaxel added to bicalutamide in Hormone-Naïve non-metastatic prostate cancer with rising PSA, a randomized clinical trial (SPCG-14)

Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). Materials and Methods:

Ex vivo, in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies

We present a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used to perfuse the body with 10% formalin, to allow further use of the body for anatomical research or teaching. The aim of our method is to develop a vascular fixation protocol for the human brain, by adapting protocols that a