BACKGROUND: Laminin alpha2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin alpha1 chain ameliorates the disease in mice. Dystroglycan and integrins are major laminin receptors. Unlike laminin alpha2 chain, alpha1 chain binds the receptors by separate domains; laminin globular (LG) domains 4 and LG1-3, respectively

Artikeln undersöker vad bestämmelsen om Sveriges EU-medlemskap och om internationellt samarbete i 1 kap. 10 § regeringsformen betyder rättsligt för den offentliga förvaltningen, särskilt avseende socialförsäkringsrätten och Försäkringskassan. En bakgrund till bestämmelsen är internationaliseringen av den offentliga rätten. Utvecklingen har inneburit att en stor del av de normer som svenska myndigh

The success of most software companies depends largely on software product quality. High product quality is usually a result of advanced software development processes. Hence, improvement actions should be selected based on sound knowledge about the dependencies between software product quality attributes and software development processes. This article describes a method for developing product/pr

The radiative lifetimes of the states in the (n=5-8) 3snp P-1(1) sequence of neutral magnesium were investigated using time-resolved laser-induced fluorescence. Excitation from the 3s2 S-1(0), ground state was performed using VUV radiation, which was produced by resonant sum-difference frequency mixing in a krypton gas cell. We find tau(n=5): 54(3) ns, tau(n=6): 140(10) ns, tau(n=7): 290(20) ns, t

Short article on the relationship between the mysticism and inherent poetics of Emanuel Swedenborg, and ideas about materiality and corporeality

This paper presents a framework for assessing alignment between corporate strategy, procurement strategy and purchasing tools. The framework is built on generation of rents as its common denominator for assessing alignment between the levels. Three types of rents are identified, monopoly rents (utilising market power, squeezing out cost), Ricardian rents (realising value from scarce intrafirm reso

This paper considers the impact of threats on professional service workers, especially as these emerge in healthcare services. Based on interviews with healthcare professionals and prison guards, this paper discusses the ethical dilemmas inherent in viewing the doctor-patient relationship from a solely rule-based ethical approach when threatening behaviour is involved. It is argued that under thre

Background: Computed tomography angiography (CTA) of intracranial arteries has high demands on image quality. Important parameters influencing vessel enhancement are injection rate, concentration of contrast media and tube voltage. Purpose: To evaluate the impact of an increase of contrast media concentration from 300 to 400 mg iodine/mL (mgI/mL) and the effect of a decrease of tube voltage from

Four recombinant Saccharomyces cerevisiae strains with enhanced xylose growth (TMB3400, C1, C5 and BH42) were compared with two control strains (TMB3399, TMB3001) through genome-wide transcription analysis in order to identify novel targets for inverse metabolic engineering. A subset of 13 genes with changed expression levels in all improved strains was selected for further analysis. Thirteen vali