Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue homeostasis during development and adult life. Here, we review some of the major phenotypic characteristics of the hostile tumour microenvironment and

Mating systems and parental care are predicted to coevolve because the former dictates the cost-benefit ratio of the latter by affecting genetic relatedness between adults and offspring. Reptiles show only rudimentary forms of sociality and parental care and, hence, could provide important insights into the early stages of the evolution and maintenance of social systems. The skink genus Egernia ex

Syftet med artikeln är att försöka tolka varför Tumme reste en runsten över sin broder Assur vid kanten av Ryssbysjön i Tuna gärde i Småland.

The magnitude squared coherence (MSC) spectrum is an often used frequency-dependent measure for the linear dependency between two stationary processes, and the recent literature contain several contributions on how to form high-resolution data-dependent and adaptive MSC estimators, and on the efficient implementation of such estimators. In this work, we further this development with the presentati

The purpose of this doctoral study is to bring a spatial dimension into the research on urban mobilities and connect the spatial dimension to the marginalisation of cyclists in urban space. This is been done by exploring the role of urban bicycling and transport planning. The theoretical frame of space, mobilities and power is used for analysing that role through case studies in two Scandinavian c

Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were ra

A detector with high dynamic range designed for combined small-and wide-angle x-ray scattering experiments has been developed. It allows measurements on single events and reactive systems, such as particle formation in flames and evaporation of levitating drops. The detector consists of 26 channels covering a region from 0.5 degrees to 60 degrees and it provides continuous monitoring of the sample

Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standar

Several lines of research have shown that the excitability of the inferior olive is suppressed during different phases of movement. A number of different structures like the cerebral cortex, the red nucleus, and the cerebellum have been suggested as candidate structures for mediating this gating. The inhibition of the responses of the inferior olivary neurons from the red nucleus has been studied

This is a paper about ownership and governance in a jointly owned local government organization providing water services (Water and Se wage South). The paper discusses the conditions for governance and ownership influence in a jointly owned local government organisation. Extra attention is directed to the issues concerned with merging existing municipal organisations, previously acting solely with

Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1-15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9; 22), der(11q23), or t(12; 21). The median age of patients with "classic" high hyperdiploidy was lower than that o

Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly regulated process that involves different mechanisms depending on which receptor-ligand pair that is studied. Galectin-3, a member of a large family of beta-galactoside-binding lectins, has been suggested

This inaugural lecture in the Royal Swedish Academy of Letters, History and Antiquities discusses the silence in Swedish press and in the Church of Sweden on National socialism, 1933-1939. This silence was neither common nor general, it was often concentrated to certain levels or matters. Silence could be compact, while the silent persons could speak on other levels, in other words, often in a the

We carried out a combined study of UV-VUV luminescence and resonant x-ray emission from BeO single crystals with incident photon energies in the vicinity of the Be 1s absorption edge. The x-ray emission spectra show that at the Be 1s photoabsorption edge the lattice relaxation processes in the excitation site take place already on the timescale of the radiative decay of the core excitation. Compar

The effect of reaction temperature, water content, and vanadia content on the sintering of a model vanadia on silica-titania SCR catalysts has been investigated. A comparison is also made to a monolithic vanadia/titania catalyst submitted to conditions simulating at least 500,000 km driving on a diesel truck. The variation of the surface area, the pore structure and the crystallite size of the cat

Gasoline partially premixed combustion (PPC) has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions. The problem is the ignitability at low load and idle operating conditions. In a previous study it was shown that it is po

Spatial multiplexing using Massive MIMO has been shown to have very promising properties, including large gains in spectral efficiency and several orders of magnitude lower transmit power, as compared to today's access schemes. The properties of massive MIMO have been studied mostly for theoretical channels with independent and identically distributed (i.i.d.) complex Gaussian coefficients. To eff

Aims P2Y(12) receptor antagonism and platelet inhibition by prasugrel vs. clopidogrel were investigated in patients with stable coronary artery disease. Methods and results One hundred and ten aspirin treated subjects were randomized to double-blind treatment with clopidogrel (n = 55) 600 mg loading dose (LD) and 75 mg maintenance dose (MD) or prasugrel (n = 55) 60 mg LD and 10 mg MD for 28 days.

Aims The recurrence of foot ulcers is a significant problem in people with diabetic neuropathy. The purpose of this study was to measure in-shoe plantar pressures and other characteristics in a group of neuropathic patients with diabetes who had prior foot ulcers which had remained healed. Methods This was an epidemiological cohort study of patients from diabetes clinics of two Swedish hospitals.

Objective: To determine plasma apolipoprotein M ( apoM) levels and other lipid profiles in hepatocellular carcinoma ( HCC) patients compared to other chronic liver diseases and normal subjects. Materials and methods: 36 HCC, 68 chronic hepatitis, 29 liver cirrhosis patients and 64 normal controls were subjected in the present study. Serum lipids, lipoproteins, apolipoprotein AI ( apoAI) and apoB w