Sökresultat

Filtyp

Din sökning på "*" gav 535632 sökträffar

Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration

Previous studies have shown that the functional efficacy of intrastriatal transplants of fetal dopamine (DA) neurons in the rat Parkinson model depends on their ability to establish a new functional innervation of the denervated striatum. Here we report that the survival, growth, and function of the grafted DA neurons greatly depend on the severity of the lesion of the host nigrostriatal system. F

Alternative Explanations for "Multistate" Kinetics in Protein Folding: Transient Aggregation and Changing Transition-State Ensembles

Deviations from classical two-state kinetics in protein folding need not always be explained by the presence of rapidly formed intermediates. In some cases, such deviations are caused by short-lived aggregates whereas in other cases they arise from changes of the position of the transition state. These are two new facets of the mechanism of two-state folding. The first part of this account describ

Short-term BOD (BODst) as a parameter for on-line monitoring of biological treatment process. Part II: Instrumentation of integrated flow injection analysis (FIA) system for BODst estimation

An instrument with integrated flow injection analysis (FIA) system has been developed for on-line monitoring a process for conversion of biomass under field condition. The instrument consists of a newly designed biosensor for easy renewal of the bio-receptor without disassembling the sensor, a FIA controller for controlling the analysis operations, and a computer-based data acquisition system for

Different protein A immunosorbents may have different binding specificity for rat immunoglobulins

Purified polyclonal immunoglobulin preparations representing the 4 rat IgG subclasses were tested for binding to Staphylococcus aureus protein A attached to 3 different solid phases (Staphylococcus aureus Cowan I bacteria, Sepharose CL4B and Sepharose 6MB). Protein A Sepharose CL4B showed higher reactivity with IgG1 and IgG2b than the staphylococci, whereas protein A Sepharose 6MB showed a lower u

Influence of temperature, particle size and humidity on the gypsum dehydration process. Investigations in a Cahn-thermobalance

The aim of the present work was to compare natural and chemical gypsums with respect to dehydration rate and to investigate the influence of air temperature, particle size and air humidity. No difference in calcination rate could be observed between natural and FGD-gypsum. However the small samples did not permit tests of setting times or simulation of the mixer behaviour. The calcination rate was

Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer

Background. During the past decade, experimental studies have provided convincing evidence that microcirculatory dysfunction plays a pivotal role in the manifestation of tissue injury in ischemia-reperfusion and osteomyocutaneous flap transfer. The study of the mechanisms of injury, however, requires sophisticated experimental in vivo models. With the use of microsurgical techniques, osteomyocutan

Asymmetric optokinetic after-nystagmus induced by active or passive sustained head rotations

Asymmetric vestibular function affects optokinetic after-nystagmus (OKAN) in man, but little is known about the involvement of cervical proprioception in the visual-vestibular interaction reflected as OKAN. We studied the effect of asymmetric cervical proprioception induced by active maximal, or passive 70 degrees sustained horizontal head rotations on OKAN in 16 healthy subjects. We evoked optoki

A study of Tamm-Horsfall protein excretion in hypertensive patients and type 1 diabetic patients

OBJECTIVE: The study was performed in order to evaluate to what extent hypertension or diabetes mellitus may affect the urinary excretion rate of Tamm-Horsfall protein. MATERIALS AND METHOD: The urinary excretion rates of albumin and Tamm-Horsfall protein, a measure of glomerular and distal tubular function, respectively were measured in patients with essential hypertension (n = 17) and in type 1

Dendritic cell presentation of type II collagen

Type II collagen (CII) is the main protein component of cartilage and immune recognition of CII plays a critical role for the development of collagen induced arthritis (CIA), a widely used animal model for rheumatoid arthritis (RA). Antigen presentation is an important requirement for the immune response, the more efficient presentation of the antigen the better tolerance will be induced and ther

The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR

Invariant NKT cells (iNKT cells) are characterized by a semi-invariant TCR comprising an invariant a-chain paired with beta-chains with limited BV gene usage which are specific for complexes of CD1d and glycolipid Ags like a-galactosylceramide (a-GalCer). iNKT cells can be visualized with a-GalCer-loaded CD1d tetramers, and the binding of mouse CD1d tetramers to mouse as well as to human iNKT cell