Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α(1)-microglobulin.
Preeclamptic women have increased plasma levels of free fetal hemoglobin (HbF), increased gene expression of placental HbF and accumulation of free HbF in the placental vascular lumen. Free hemoglobin (Hb) is pro-inflammatory, and causes oxidative stress and tissue damage.
