Sökresultat

Filtyp

Din sökning på "*" gav 528838 sökträffar

Nietzsche as educator

Our title is a play on Nietzsche’s Schopenhauer as Educator first published in his essay collection Unfashionable Observations. Within the setting of teaching and studying management practice our chapter is also unfashionable. It argues for a primacy of honesty in feeling in a practice that can encourage the rational selection and manipulation of viewpoints. It argues for cheerful and generous exp

Formation of wide-orbit giant planets in protoplanetary disks with a decreasing pebble flux

The presence of distant protoplanets may explain the observed gaps in the dust emission of protoplanetary disks. Here, we derive a novel analytical model to describe the temporal decay of the pebble flux through a protoplanetary disk as the result of radial drift. This has allowed us to investigate the growth and migration of distant protoplanets throughout the lifespan of the disk. We find that M

Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4 + 1] Annulation of Difluorocarbene and Antitumor Activity Evaluation

As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF2 source for the construction of gem-difluorinated ring structures. Here, we develop a protocol for the efficient assembly of valuable fluorinated 2,3-dihydrobenzofurans from the [4 + 1] annulation in good yields under basic conditions. The reliable practicabil

Enhanced surveillance of hospitalized COVID-19 patients in Europe : an evaluation of the I-MOVE-COVID-19 surveillance network

Background: A pre-existing, well-established European influenza surveillance network known as I-MOVE enabled the rapid implementation of a European multi-country COVID-19 hospital surveillance network for surveillance of hospitalized COVID-19 cases in early 2020. This network included 257 hospitals in 11 surveillance sites across nine countries. We aimed to identify whether the surveillance object

Majorana Qubits and Non-Abelian Physics in Quantum Dot-Based Minimal Kitaev Chains

The possibility of engineering artificial Kitaev chains in arrays of quantum dots coupled via narrow superconducting regions has emerged as an attractive way to overcome the disorder issues that complicate the realization and detection of topological superconducting phases in other platforms. Although a true topological phase would require long chains, a two-site chain realized in a double quantum

Switching Off Vascular MAPK Signaling : A Novel Strategy to Prevent Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage

Patients who initially survive the rupture and repair of a brain aneurysm often take a devastating turn for the worse some days later and die or suffer permanent neurologic deficits. This catastrophic sequela is attributed to a delayed phase of global cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH), but we lack effective treatment. Here we present our view, based on 20

Automated Multi-Atlas Segmentation of Hippocampal and Extrahippocampal Subregions in Alzheimer's Disease at 3T and 7T : What Atlas Composition Works Best?

BACKGROUND: Multi-atlas segmentation, a popular technique implemented in the Automated Segmentation of Hippocampal Subfields (ASHS) software, utilizes multiple expert-labelled images ("atlases") to delineate medial temporal lobe substructures. This multi-atlas method is increasingly being employed in early Alzheimer's disease (AD) research, it is therefore becoming important to know how the constr

Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI

Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in health

Multi-template analysis of human perirhinal cortex in brain MRI : Explicitly accounting for anatomical variability

RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different

Zombie leadership : Dead ideas that still walk among us

Considerable progress has been made in the field of leadership in recent years. However, we argue that this is undermined by a strong residual commitment to an older set of ideas which have been repeatedly debunked but which nevertheless resolutely refuse to die. These, we term zombie leadership. Zombie leadership lives on not because it has empirical support but because it flatters and appeals to

Exposure to comprehensive sexuality education in schools in South Africa : the implications on the uptake of HIV testing services among HIV positive adolescent girls

Comprehensive sexuality education (CSE) is seen as a key instrument through which to affect behaviour and improve sexual and reproductive health (SRH) outcomes amongst adolescents. However, few studies have to date evaluated key SRH outcomes following exposure to CSE within a school setting. This study estimates the association between CSE and HIV testing and HIV testing self-efficacy amongst HIV

Social inequalities in the risk of giving birth to a small for gestational age child in Sweden 2010–16 : a cross-sectional study adopting an intersectional approach

Background: Well-established associations exist between the risk of small for gestational age (SGA) and unidimensional sociodemographic factors. We investigated social inequalities in SGA risk and adopted an intersectional approach that simultaneously considers different social categories. By doing so, we could assess heterogeneities in SGA risk within unidimensional sociodemographic categories. M

Midwives' Experiences of Intact Cord Resuscitation in Nonvigorous Neonates After Vaginal Birth in Sweden

OBJECTIVE: To describe midwives' experiences of intact cord resuscitation close to the mother for nonvigorous neonates after vaginal birth.DESIGN: Descriptive qualitative.SETTING: Four labor wards in Sweden.PARTICIPANTS: Midwives (N = 13) currently or previously employed in labor wards where the Sustained Cord Circulation and Ventilation (SAVE) study was conducted.METHODS: We analyzed semistructur

Reference limits for osteocalcin in infancy and early childhood : A longitudinal birth cohort study

OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).DESIGN: Blood samples from 551 Swedish chil