TNFalpha expression in monocytes/macrophages
The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). TNF is a pleotropic cytokine with actions ranging from tissue injury to septic chock. T