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In vitro Transcription/Translation System: A Versatile Tool in the Search for Missing Proteins

Approximately 18% of all human genes purported to encode proteins have not been directly evidenced at the protein level, according to the validation criteria established by neXtProt, and are considered as “missing” proteins. One of the goals of the Chromosome-Centric Human Proteome Project (C-HPP) is to identify as many of these “missing” proteins as possible in human samples using mass spectromet

Optimal results for the nonhomogeneous initial-boundary value problem for the two-dimensional Navier-Stokes equations

In this work we study the fully nonhomogeneous initial boundary value problem for the two-dimensional time-dependent Navier–Stokes equations in a general open space domain in R2 with low regularity assumptions on the initial and the boundary value data. We show that the perturbed Navier–Stokes operator is a diffeomorphism from a suitable function space onto its own dual and as a corollary we get t

Brain Areas Consistently Linked to Individual Differences in Perceptual Decision-making in Younger as well as Older Adults before and after Training

Perceptual decision-making performance depends on several cognitive and neural processes. Here, we fit Ratcliff's diffusion model to accuracy data and reaction-time distributions from one numerical and one verbal two-choice perceptual-decision task to deconstruct these performance measures into the rate of evidence accumulation (i.e., drift rate), response criterion setting (i.e., boundary separat

Estimation of Soil Base Cation Weathering Rates with the PROFILE Model to Determine Critical Loads of Acidity for Forested Ecosystems in Pennsylvania, USA: Pilot Application of a Potential National Methodology

Base cation weathering (BCw) rate is one of the most influential yet difficult to estimate parameters in the calculation of critical acid loads of nitrogen (N) and sulfur (S) deposition for terrestrial systems. Only the clay correlation-substrate method, a simple empirical model, has been used for estimating BCw rates for forest ecosystems in the conterminous USA and may not be suitable for applic

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Abstract in Norwegian Det er kjent fra før at langdistansebinding, altså binding over finitt setningsgrense, forekommer i norsk. Den geografiske distribusjonen av slike bindingsrelasjoner i norsk har blitt undersøkt tidligere, og det samme har visse semantiske og syntaktiske faktorer som gjør langdistansebinding mulig. I denne artikkelen presenteres resultater fra en ny undersøkelse av langdistans

Search for microscopic black holes and string balls in final states with leptons and jets with the ATLAS detector at root s=8 TeV

A search for an excess of events with multiple high transverse momentum objects including charged leptons and jets is presented, using 20.3 fb(-1) of proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2012 at a centre-of-mass energy of root s = 8 TeV. No excess of events beyond Standard Model expectations is observed. Using extra-dimensional models for blac

Temperature and annealing effects on InAs nanowire MOSFETs

We report on temperature dependence on the drive current as well as long-term effects of annealing in vertical InAs nanowire Field-Effect Transistors. Negatively charged traps in the HfO2 gate dielectric are suggested as one major factor in explaining the effects observed in the transistor characteristics. An energy barrier may be correlated with an un-gated InAs nanowire region covered with HfO2

Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

To circumvent antiandrogen resistance in prostate cancer, antiandrogens effective for both the androgen receptor (AR) and AR mutants are required. The AR antagonists in this study originate from previous findings, which showed that subtle differences in substitution pattern lead to a conformational change that alters the ligand activity, rendering an agonist to an antagonist. We have identified sm

Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and γ-Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level.

In clinical practice as well as research situations, it is of great importance to get reliable information about a patient's alcohol consumption. The aim of the study was to investigate the correlation of alcohol biomarkers (phosphatidylethanol [PEth], carbohydrate-deficient transferrin [CDT], γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase) to retrospective as well

Input frequency and the acquisition of subject-verb agreement in numner in spoken and written French

The present study focuses on the characteristics of subject-verb agreement in number in spoken and written French, two morphological systems that are very different. In particular, we investigate the impact of frequency of forms and morphological patterns in the input on the acquisition of number agreement in monolingual and bilingual French-speaking children (n=32). Our results demonstrate an alm

Adaptation to Swedish and further development of the 'Consequences of Screening - Breast Cancer' questionnaire: a multimethod study.

Scand J Caring Sci; 2012 Adaptation to Swedish and further development of the 'Consequences of Screening - Breast Cancer' questionnaire: a multimethod study Rationale: Experiencing a false-positive screening mammography can cause considerable psychosocial distress. The Consequences of Screening - Breast Cancer questionnaire (COS-BC parts 1 and 2), recently developed in Denmark, is the only conditi

The effect of modelling acoustic media in cavities of lightweight buildings on the transmission of structural vibrations

Determining the dynamic behaviour of lightweight buildings by means of finite element analyses requires models representing the geometry involved in great detail, resulting in systems having many millions of degrees of freedom. It is, therefore, important to avoid unnecessarily detailed models by carefully considering what is essential to include in the models and the level of details required for

Contact allergy to common ingredients in hair dyes

Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 1

Visual Cryptography and Obfuscation: A Use-Case for Decrypting and Deobfuscating Information using Augmented Reality

As new technologies emerge such as wearables, it opens up for new challenges, especially related to security and privacy. One such recent technology is smart glasses. The use of glasses introduces security and privacy concerns for the general public but also for the user itself. In this paper we present ongoing theoretical work which focus on privacy of the user during authentication. We propose a