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The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation

Small leucine-rich proteoglycans interact with other extracellular matrix proteins and are important regulators of matrix assembly. Fibromodulin has a key role in connective tissues, binding collagen through two identified binding sites in its leucine-rich repeat domain and regulating collagen fibril formation in vitro and in vivo Some nine tyrosine residues in the fibromodulin N-terminal domain a

Violation of Onsager's theorem in approximate master equation approaches

The consistency with Onsager's theorem is examined for commonly used perturbative approaches, such as the Redfield and second-order von Neumann master equations, for thermoelectric transport through nanostructures. We study a double quantum dot, which requires coherences between states for a correct description, and we find that these perturbative approaches violate Onsager's theorem. We show that

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology

Alzheimer's disease (AD) is the most common cause of dementia. Biomarkers are required to identify individuals in the preclinical phase, explain phenotypic diversity, measure progression and estimate prognosis. The development of assays to validate candidate biomarkers is costly and time-consuming. Targeted proteomics is an attractive means of quantifying novel proteins in cerebrospinal and other

Resolving the problem of trapped water in binding cavities : prediction of host–guest binding free energies in the SAMPL5 challenge by funnel metadynamics

The funnel metadynamics method enables rigorous calculation of the potential of mean force along an arbitrary binding path and thereby evaluation of the absolute binding free energy. A problem of such physical paths is that the mechanism characterizing the binding process is not always obvious. In particular, it might involve reorganization of the solvent in the binding site, which is not easily c

Using a modified 3D-printer for mapping the magnetic field of RF coils designed for fetal and neonatal imaging

An experimental setup for characterizing the magnetic field of MRI RF coils was proposed and tested. The setup consisted of a specially configured 3D-printer, a network analyzer and a mid-performance desktop PC. The setup was tested on a single loop RF coil, part of a phased array for fetal imaging. Then, the setup was used for determining the magnetic field characteristics of a high-pass birdcage

On the origins of physical cognition in corvids

Physical cognition involves a host of cognitive abilities that enable understanding and manipulation of the physical world. Corvids, the bird family that includes crows, ravens and jays, are renowned for their cognitive abilities, but still little is known about their folk physics. This thesis explores the origins of physical cognition in corvids by investigating its mechanisms, development,fitnes

Leading logarithms for mesons and nucleons

This talk describes the work done in calculating leading logarithms in massive effective field theories. We discuss shortly leading logarithms in renormalizable theories and how they can be calculated using only one-loop calculations in effective field theories. The remainder of the talk discusses masses, decay constants, condensates and anomalous processes in mesonic effective field theories like

Rätten i den fysiska planeringen. Tre teoretiska perspektiv

Detta kapitel rör sig i spänningsfältet mellan rättssociologi och fysisk planering i syfte att visa på hur den senare kunde utvecklas genom bidrag från den förras vidgade förståelse för och av rätten. Analysen, som grundas på material från empiriska studier av utbyggnaden av 3G-systemet och av vindkraften, fokuserar rättens roll i planeringen ur tre perspektiv som är vanliga i rättssociologisk for

Methanol Adsorption and Oxidation on Reduced and Oxidized TbOx(111) Surfaces

We used temperature programmed reaction spectroscopy (TPRS) and synchrotron-radiation based photoelectron spectroscopy (PES) to investigate the adsorption and oxidation of methanol (CH3OH) on Tb2O3(111) and TbO2(111) thin films grown on Pt(111). We find that methanol mainly desorbs from the Tb2O3 surface through both molecular and recombinative processes, and that a relatively small amount of adso

A layered rhabdom in an isopod (Crustacea). A case of convergent development.

The isopod species Astacilla longicornis (Sowerby) has a layered rhabdom, which is the first case reported in isopod crustaceans. The rhabdom comprises the rhabdomeres of six retinular cells. It is surrounded by an extracellular palisade. Usually, palisades are intracellular in arthropods. A layered rhabdom is found in taxonomically widely separated groups within the Arthropoda and no intermediate

Evacuation modelling for underground physics research facilities

This document presents the results of a literature review performed in order to assess the suitability of different evacuation modelling tools for the calculation of evacuation times and assessment of fire safety in underground physics research facilities. This document is part of the research collaboration between Lund University and the European Organization for Nuclear Research (CERN), concerni

Auxin Acts through MONOPTEROS to Regulate Plant Cell Polarity and Pattern Phyllotaxis

The periodic formation of plant organs such as leaves and flowers gives rise to intricate patterns that have fascinated biologists and mathematicians alike for hundreds of years [1]. The plant hormone auxin plays a central role in establishing these patterns by promoting organ formation at sites where it accumulates due to its polar, cell-to-cell transport [2-6]. Although experimental evidence as