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Enrichment of antibiotic resistance genes within bacteriophage populations in saliva samples from individuals undergoing oral antibiotic treatments

Spread of antibiotic resistance is a significant challenge for our modern health care system, and even more so in developing countries with higher prevalence of both infections and resistant bacteria. Faulty usage of antibiotics has been pinpointed as a driving factor in spread of resistant bacteria through selective pressure. However, horizontal gene transfer mediated through bacteriophages may a

The Meaning of Sense of Coherence (SOC) in Persons with Late Effects of Polio—A Qualitative Study

Sense of Coherence (SOC), comprising comprehensibility, manageability and meaningful-ness, is important for the sense of living a good life with Late Effects of Polio (LEoP). However, there is a lack of knowledge about the meaning of these three components. The aim of this study was to explore in-depth the meaning of SOC among persons living with LEoP, in terms of comprehensibility, manageability

Computed tomography in acute intracerebral hemorrhage : neuroimaging predictors of hematoma expansion and outcome

Intracerebral hemorrhage (ICH) accounts for 10–20% of all strokes worldwide and is associated with serious outcomes, including a 30-day mortality rate of up to 40%. Neuroimaging is pivotal in diagnosing ICH as early detection and determination of underlying cause, and risk for expansion/rebleeding is essential in providing the correct treatment. Non-contrast computed tomography (NCCT) is the most

Clinical significance of stem cell biomarkers epcam, lgr5 and lgr4 mrna levels in lymph nodes of colon cancer patients

The significance of cancer stem cells (CSCs) in initiation and progression of colon cancer (CC) has been established. In this study, we investigated the utility of measuring mRNA expression levels of CSC markers EpCAM, LGR5 and LGR4 for predicting survival outcome in surgically treated CC patients. Expression levels were determined in 5 CC cell lines, 66 primary CC tumors and 382 regional lymph no

Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy (IPSNUT) : protocol of a systematic review

Background: Clinical research has shown that therapeutic hypothermia after neonatal hypoxic-ischemic injury improves survival without disability. There is no consensus regarding pain relief or sedation during therapeutic hypothermia in newborns; however, therapeutic hypothermia seems to be associated with pain and stress, and adequate analgesia and sedation are central to maximize the effect of th

Ladder-like Polymer Brushes Containing Conjugated Poly(Propylenedioxythiophene) Chains

The high stability and conductivity of 3,4-disubstituted polythiophenes such as poly(3,4-ethylenedioxythiophene) (PEDOT) make them attractive candidates for commercial applications. However, next-generation nanoelectronic devices require novel macromolecular strategies for the pre-cise synthesis of advanced polymer structures as well as their arrangement. In this report, we present a synthetic rou

Dynamics of Strength Gain in Sandy Soil Stabilised with Mixed Binders Evaluated by Elastic P-Waves during Compressive Loading

This paper addresses the problem of stabilisation of poor subgrade soil for improving its engineering properties and stiffness. The study aim is to evaluate the effects from single and mixed binders on the gain of strength in sandy soil over the period of curing. We propose an effective non-destructive approach of using P-waves for identifying soil strength upon stabilisation. The growth of streng

Modeling of Diffusion-Controlled Crystallization Kinetics in Al-Cu-Zr Metallic Glass

Crystallization is a major challenge in metallic glass production, and predictive models may aid the development of controlled microstructures. This work describes a modeling strategy of nucleation, growth and the dissolution of crystals in a multicomponent glass-forming system. The numerical model is based on classical nucleation theory in combination with a multicomponent diffusion-controlled gr

Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock

Background: The use of norepinephrine in the case of life-threatening haemorrhagic shock is well established but widely discussed. The present study was designed to compare the effects of early norepinephrine treatment vs. no treatment on cerebral energy metabolism during haemorrhagic shock. Methods: Twelve pigs were subjected to haemorrhagic shock, 4 in the control group and 8 in the norepinephri

Freely available convolutional neural network-based quantification of PET/CT lesions is associated with survival in patients with lung cancer

Background: Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- and inter-reader variability and is too time-consuming in clinical practice. The use of modern artificial intelligence-based methods offers new possibilities for automated and obj

The Design of 3D-Printed Polylactic Acid–Bioglass Composite Scaffold : A Potential Implant Material for Bone Tissue Engineering

Bio-based and patient-specific three-dimensional (3D) scaffolds can present next generation strategies for bone tissue engineering (BTE) to treat critical bone size defects. In the present study, a composite filament of poly lactic acid (PLA) and 45S5 bioglass (BG) were used to 3D print scaffolds intended for bone tissue regeneration. The thermally induced phase separation (TIPS) technique was use

Mass Transport of Lignin in Confined Pores

A crucial step in the chemical delignification of wood is the transport of lignin fragments into free liquor; this step is believed to be the rate-limiting step. This study has investigated the diffusion of kraft lignin molecules through model cellulose membranes of various pore sizes (1–200 nm) by diffusion cells, where the lignin molecules diffuse from donor to acceptor cells through a membrane,

How Can Sewage Sludge Use in Sustainable Tunisian Agriculture Be Increased?

In recent years, farmers in Beja, an agricultural governorate in northwestern Tunisia, have expressed their willingness to use urban sewage sludge as agricultural fertilizer, especially with the unavailability of chemical fertilizers and the soil type of the region that is poor in organic matter. However, there is an imbalance between the important farmers’ demand versus the limited quantity of sl

Hydraulic Modeling and Remote Sensing Monitoring of Floodhazard in Arid Environments—A Case Study of Laayoune City in Saquia El Hamra Watershed Southern Morocco

Morocco often faces significant intense rainfall periods that can generate flash floods and raging torrents, causing serious damage in a very short period of time. This study aims to monitor wetland areas after a flash-flood event in an arid region, Saquia El hamra Saharan of Morocco, using a technique that combines hydraulic modeling and remote sensing technology, namely satellite images. The hyd

Implementation of physical activity on prescription for children with obesity in paediatric health care (IMPA) : protocol for a feasibility and evaluation study using quantitative and qualitative methods

Background: Physical inactivity is a main cause of childhood obesity which tracks into adulthood obesity, making it important to address early in life. Physical activity on prescription (PAP) is an evidence-based intervention that has shown good effect on physical activity levels in adults, but has not been evaluated in children with obesity. This project aims to evaluate the prerequisites, determ

Diagnostic yield is dependent on monitoring duration. Insights from a full-disclosure mobile cardiac telemetry system

Background: Despite the advancement of electrocardiogram (ECG) monitoring methods, the most important factor influencing diagnostic yield (DY) may still be monitoring duration. Ambulatory ECG monitoring, typically with 24–48 hours duration, is widely used but may result in underdiagnosis of rare arrhythmias. Aims: This study aimed to examine the relationship between the DY and monitoring duration