Inherent difficulties in growing protein crystals are major concerns within structural biology and particularly in structural proteomics. Here, we describe a novel approach of engineering target proteins by surface mutagenesis to increase the odds of crystallizing the molecules. To this end, we have exploited our recent triad-hypothesis using proteins with crystallographically defined beta-structu

The study aimed to investigate (a) if women's perceptions of their work environment changed during a 16-week rehabilitation period and at a 12-month follow-up; (b) whether such changes were related to outcomes in terms of return to work, well-being and valued occupations.

OBJECTIVES: To analyze whether there is an association between neighborhood deprivation and cervical cancer morbidity and mortality, beyond individual level characteristics. DESIGN: The entire Swedish population aged 25 to 74, a total of 1.9million women, were followed from January 1, 1990, until hospital admission due to cervical cancer during the study period, or the end of the study on Dece

This article explores how the 'liberal democratic peace package' is received in post-conflict spaces. As such, it is part of a critical peace research agenda that raises critical questions concerning the quality of peace in many post-conflict societies. A close reading of the peace-building process in post-conflict Kosovo provides the backdrop for the theoretical discussion that identifies frictio

We present the concept of the Carbon Cycle Data Assimilation System and describe its evolution over the last two decades from an assimilation system around a simple diagnostic model of the terrestrial biosphere to a system for the calibration and initialization of the land component of a comprehensive Earth system model. We critically review the capability of this modeling framework to integrate m

The European Spallation Source (ESS) is a neutron-scattering facility being built with extensive international collaboration in Lund, Sweden. The ESS accelerator will deliver protons with 5 MW of power to the target at 2.0 GeV, with a nominal current of 62.5 mA. The superconducting part of the accelerator is about 300 meters long and contains 43 cryomodules. The ESS accelerator cryoplant (ACCP) wi

Pneumonia is a form of lung infection that may be caused by various micro-organisms. The predominant site of infection in pneumonia is debatable. Advances in the fields of diagnostic and therapeutic medicine have had a less than optimal effect on the outcome of pneumonia and one of the many causes is likely to be inadequate antimicrobial concentrations at the site of infection in lung tissue. Trad

Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/

The timing of migration is generally considered of utmost importance for reproduction and survival, and timing is furthermore considered to be under strong genetic control. The individual timing of migration is presumably a result of a combination of genetic, phenotypic and environmental factors as well as some degree of randomness. However, potential differences in consistency of timing between s

In I-123-IBZM brainSPECT, the main interest is the activity uptake in the striatum relative to the background, and semi-quantitative techniques using regions of interest are typically used for this purpose. Uncertainties in the measured uptakes can however be a problem due to low contrasts and high noise levels. Like SPECT in general, IBZM SPECT should benefit from reconstruction methods that incl

Abstract in UndeterminedI Ryssland har familj och familjevärderingar sedan mitten på 2000-talet kommit att bli centrala för en allmän ideologisk svängning mot konservativa värderingar och patriotism. Symptomatisk för denna tendens är den så kallade Föräldrarörelsen, en växande och starkt nationalistisk gräsrotsmobilisering med syfte att försvara föregivet traditionella ryska familjevärderingar mot

Abstract in Undetermined This study employed microCT to investigate whether image resolution affects bone structural parameters differently in healthy normal and osteoporotic trabecular bone. With increasing image voxel size, the originally detected differences between sample groups diminished. The results suggest that structural differences may not be reliably detected with clinical scanners.

The design of sampling schemes affects the results of biodiversity inventories. As an approach for quantifying the implications of such effects, we compared data on spider communities sampled in a beech-dominated forest floor habitat by 1) a regular grid of pitfall traps (systematic design) and 2) an expert-based distribution of traps (stratified design). We tested whether the two designs would le

Efficient light-emitting diodes and photovoltaic energy-harvesting devices are expected to play an important role in the continued efforts towards sustainable global power consumption. Semiconductor nanowires are promising candidates as the active components of both light-emitting diodes and photovoltaic cells, primarily due to the added freedom in device design offered by the nanowire geometry. H

Since the end of the 1990s, the number of fires has increased dramatically in Malmö, a city in the southernmost part of Sweden. Between 1998 and 2009, the increase was 215%, and a large number of the fires were intentional. The aim of this paper is to deepen our understanding of the underlying causes of the spatial and spatio-temporal distribution of intentional fires in Malmö, and to analyse how

Fusobacterium necrophorum causes Lemièrre's syndrome, a serious disease with septic thrombophlebitis of the internal jugular vein, pulmonary involvement and systemic inflammation. The contact system is a link between inflammation and coagulation and contact activation by the bacteria could therefore contribute to the abnormal coagulation and inflammation seen in patients with Lemièrre's syndrome.

The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brai

Vitellogenin (VTG) is a well-known biomarker for endocrine disruption and the measurement of alkali-labile protein bound phosphate (ALP) has been used as an indirect quantification method for VTG in fish, clam and mussel. One limitation of the ALP method has been the insufficient detection limit but with the method presented here this obstacle has been overcome, enabling measurement in fish specie