Autoimmune mechanisms have been implicated in the pathophysiology of diabetic neuropathy. We studied the association between glutamic acid decarboxylase (GAD65) and islet cell (IA-2) autoantibodies as well as autoantibodies to the autonomic nervous system and peripheral nerve function in recent onset type 1 diabetes. Thirty-seven patients (27 females and 10 males) enrolled 2-22 months after diagno

Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon cancer. However, it is not clear how HCD drives dysregulation of colon stem cell/colonocyte proliferative kinetics. We used a human-relevant pig model

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Background: Patients with insulin-dependent diabetes mellitus (IDDM) have elevated risk for periodontitis (PD) relative to subjects without diabetes. Whether refractory PD in IDDM patients is related to autoimmunity as indicated by serum glutamic acid decarboxylase autoantibody GAD Ab levels or to host bacterial immunity as reflected by serum antibody titers to periodontal pathogens is unknown. Ai

OBJECTIVE - Ketosis-prone diabetes (KPD) is an emerging, heterogeneous syndrome. A sound classification scheme for KPD is essential to guide clinical practice and pathophysiologic studies. Four schemes have been used and are based on immunologic criteria, immunologic criteria and insulin requirement, BMI, and immunologic criteria and β-cell function (Aβ classification). The aim of the present stud

Distributed algorithms for solving coupled semidefinite programs (SDPs) commonly require many iterations to converge. They also put high computational demand on the computational agents. In this paper we show that in case the coupled problem has an inherent tree structure, it is possible to devise an efficient distributed algorithm for solving such problems. The proposed algorithm relies on predic

Baculovirus-insect cell expression system has become one of the most widely used eukaryotic expression systems for heterologous protein production in many laboratories. The availability of robust insect cell lines, serum-free media, a range of vectors and commercially-packaged kits have supported the demand for maximizing the exploitation of the baculovirus-insect cell expression system. Naturally

För 300 år sedan fanns väldiga skogar med rik biologisk mångfald i Nordamerika. Tre pionjärer som dokumenterat denna idag till stora delar försvunna värld var Mark Catesby, Alexander Wilson och John James Audubon.

This report presents a meticulous review of the background of today’s flow-based society and its vulnerability. Furthermore, there is a discussion about how to define flow-based disruption risks, and how their consequences, including the domino effects, can be described. Also the theory areas, addressing this kind of risks, are treated in this report. The modern society of today is, to a great ext

Our aim was to explore the current state of e-learning activities during physiotherapy and occupational therapy education, in relation to theories and models about learning. What kind of e-learning activities were described and which were the intentions behind the use of digital support expressed in current physiotherapy and occupational therapy literature? The search was done using four different

This book by experienced journalist and metal fan Orlando Crowcroft is a must read for anyone curious about counter-culture in the Middle East. It contains six country studies (Lebanon, Egypt, Israel/Palestine, Saudi Arabia, Iran, and Syria) in which Crowcroft’s interviews with musicians are the key elements.With the knowledge of a music connoisseur, he guides the reader in the subcultural music s

The extent to which humans help each other is extraordinary in itself, and difficult to explain from an evolutionary perspective. Therefore, there has been a recent surge in studies investigating the evolution of prosocial behavior using a comparative approach. Nevertheless, most of these studies have focused on primates only, and little is known about other animal orders. In a previous study, com