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Deuterium isotope labelling is important for structural biology methods such as neutron protein crystallography, nuclear magnetic resonance and small angle neutron scattering studies of proteins. Deuterium is a natural low abundance stable hydrogen isotope that in high concentrations negatively affect growth of cells. The generation time for Escherichia coli K-12 in deuterated medium is substantia
Increasing interdependencies between critical infrastructures have made these systems more effective, but also more susceptible to cascading failures. In order to reduce the likelihood and consequences of cascading failures, it is essential to develop tools that support incident commander decisions so that an initial failure does not spread to other infrastructures. Here, a framework for generatin
Myocardin (MYOCD) is a critical regulator of smooth muscle cell (SMC) differentiation, but its transcriptional targets remain to be exhaustively characterized, especially at the protein level. Here we leveraged human RNA and protein expression data to identify novel potential MYOCD targets. Using correlation analyses we found several targets that we could confirm at the protein level, including SO
Rhythmic behaviors (in short RBs), such as applauding, dancing or rocking a baby to sleep are part of humans everyday life. Recently there has been a growing interest in the RBs of other species, as a way of tracking the evolutionary roots of human musicality. RBs have been initially studied in arthropods, insects, anurans and songbirds, where a single behaviour is tied to reproductive function. E
This paper presents a method for increased individual and collective student learning called Working Seminar. The method is based on the assumption that groups with a common base of knowledge increase both the group results and the individual learning. The method has been developed and tested in three courses and the results of student projects and the individual comments from students during and
OBJECTIVE To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study. RESEARCH DESIGN AND METHODS We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: 1) the return visit af
OBJECTIVE In type 2 diabetes, insulin resistance and progressive b-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocal
In this short paper we discuss the advantages and drawbacks of oral and written evaluation of students. First in more general terms and then followed by details of what we did in our course and our experience. Finally, we outline some topics for further study and discussions.
Trots att PBL betraktas som ett kraftfullt verktyg i undervisningen, råder fortfarande viss tvekan att den skulle vara lämplig i alla utbildningar. Ett annat problem som också diskuteras är om PBL går att tillämpas på stora grupper och i så fall om den är lönsam. I tekniska utbildningar är teknologerna oftast vana vid att ha föreläsningar, övningar och laborationer. Som stöd har man ett genomarbet
Grupparbeten utmålas som pedagogiskt fördelaktiga och av Högskoleförordningen följer, att sådana är ett viktigt inslag i civilingenjörsutbildningen. Artikeln presenterar fallgropar och svårigheter som kan aktualiseras liksom ett antal faktorer som är väsentliga vid gruppsammansättning och examination för att optimera det aktiva lärande som ett grupparbete kan bidra till.
