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Preoperative circulating tumor DNA level is associated to poor overall survival in patients with ovarian cancer

Introduction/BackgroundCirculating tumor DNA (ctDNA), which is shed from tumor cells into the blood, is a promising minimal-invasive method for cancer diagnostics and monitoring. The aim of this study was to evaluate preoperative ctDNA levels in the plasma of patients with ovarian cancer and correlate the levels to clinico-pathological parameters and patient outcome.MethodologyTumor DNA was extrac

Den empiriska glädjen. En vänbok till Malin Åkerström

Det finns energi att hämta i empiriska iakttagelser och det kan vara enfröjd att utvinna den energin. Så lyder budskapet i den här vänbokentill Malin Åkerström, professor emerita vid Lunds universitet.Med nedslag i vitt skilda fält och projekt vill författarna exemplifieraoch analysera det speciella samspel som äger rum mellan empirioch forskare i olika samhällsvetenskapliga ämnen. Det rör sig om

Impacts of ENSO on monthly precipitation in South Korea and Fukuoka, Japan

Simple but robust approaches were used to reveal the quantitative and statistically significant influence of the Southern Oscillation Index (SOI) on monthly precipitation at five stations distributed over South Korea and Fukuoka, Japan. The monthly precipitation data were transformed into non-exceedence probability time series. SOI is classified into five categories. Correlation between the catego

Future projections of wind energy potentials in the arctic for the 21st century under the RCP8.5 scenario from regional climate models (Arctic-CORDEX)

The Arctic has warmed more than twice the rate of the entire globe. To quantify possible climate change effects, we calculate wind energy potentials from a multi-model ensemble of Arctic-CORDEX. For this, we analyze future changes of wind power density (WPD) using an eleven-member multi-model ensemble. Impacts are estimated for two periods (2020–2049 and 2070–2099) of the 21st century under a high

GÅ UT OCH TA EN ÖL? : Om eufemismer för spontant men förberett graffitiskrivande

Under mitt fältarbete kring graffiti var ”ska vi inte gå och ta en öl?” en återkommandeuppmaning bland deltagarna, även formulerad som ”gå ut och röka”, ”ta en promenad”, osv. Även om dessa förslag i sig knappast är unika för graffiti, visade sig deras betydelser och konsekvenser vara just det. I detta kapitel ska jag analysera hur dessa sociala uppmaningar användes som subkulturella eufemismer fö

Investigating Design Rules for Photoinduced Electron Transfer Quenching in Triangulenium Probes

Fluorescent probes based on photoinduced electron transfer (PET) quenching of long lifetime triangulenium fluorophores have found multiple applications. For such probes a successful design relies on the right balance between the rate of PET quenching and fluorescence. In a series of ADOTA (A) and DAOTA (D) triangulenium fluorophores appended with aniline-like quencher moieties, we have investigate

Spatial variability of soil water content and salinity in a semi-arid agricultural field

En teknik för att förhindra yterosion och samla ytavrinning är bygga jordvallar (1–1,5 m höga) parallellt medhöjdkurvorna. Denna teknik används över stora områden i Tunisien. I denna studie undersöks hur dessa jord-vallar påverkar ytjordens rumsliga variabilitet av markvattenhalt (θ) och salinitet, dels uttryckt som jordenstotala elektriska konduktivitet (σa) och dels som porvattnets elektriska koOne technique for collecting rainwater and prevent soil erosion applied on large areas in Tunisia involves theuse of soil ridges (1–1.5 m high). These contour ridges are constructed parallel to topographical isolines. Theeffects of the contour ridges on the soil water content (θ) distribution, bulk soil salinity σa, and soil water salin-ity (σw) were investigated in the catchment of El-Gouazine in

Factors associated with healing failure after early repair of acute, trauma-related rotator cuff tears

Background: Healing failure after rotator cuff repair is a challenging problem. Acute, trauma-related tears are considered a separate entity and are often treated surgically. The aim of this study was to identify factors associated with healing failure in previously asymptomatic patients with trauma-related rotator cuff tears treated with early arthroscopic repair. Methods: This study included 62

Hybrid Quantized Signal Detection with a Bandwidth-Constrained Distributed Radar System

This paper addresses the hybrid quantized signal detection problem in a distributed radar system, where widely separated antennas transmit low-bit quantized data with varying quantization levels depending on the different bandwidth constraint for each channel to a fusion center. To enable a high detection performance with such hybrid quantized data, we formulate the generalized likelihood ratio, R

Ultra-stable and versatile high-energy resolution setup for attosecond photoelectron spectroscopy

Attosecond photoelectron spectroscopy has opened up for studying light–matter interaction on ultrafast time scales. It is often performed with interferometric experimental setups that require outstanding stability. We demonstrate and characterize in detail an actively stabilized, versatile, high spectral resolution attosecond beamline based on a Mach-Zehnder interferometer. The active stabilizatio

Writing in English at University : Revised and updated version

This Massive Open Online Course (MOOC), offered in partnership with online learning provider Coursera, is a free resource for university students who are currently involved in writing assignments or degree projects as well as for students who wish to learn about academic writing in order to prepare for future writing tasks at university. Although the course provides guidance to all student writers

Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis : 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial

Background: The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods: Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate-severe disease activity were random