Defective handling of proteins is a central feature of major neurodegenerative diseases. The discovery that neuronal dysfunction or degeneration can be caused by mutations in single cellular proteins has given new opportunities to model the underlying disease processes by genetic modification of cells in vitro or by generation of transgenic animals carrying the disease-causing gene. Recent develop

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Measurement of prostate-specific antigen (PSA) in blood is an important tool in detection for prostate cancer. PSA occurs in several molecular forms in blood: mainly as a free form with a molecular mass of 28 kDa; and as PSA complexed to alpha-1-antichymotrypsin, complexed PSA, with a molecular mass of 90 kDa. Total PSA comprises the sum of free PSA and complexed PSA. The percentage of free-to-tot

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The evolutionary process and its impact on speciation and emergence of genera is discussed briefly for the Teloschistaceae. Many facts which have been recognized mainly from studies of morphological variation within populations in addition to analyses of structural variation from herbarium material speak for a conceivable slow evolutionary process represented in this family. Some examples are disc

Popular Abstract in Swedish Skogen är en av Sveriges mest betydelsefulla naturresurser. Utöver det ekonomiska värdet är skogen även viktig ur ett ekologiskt, socialt och kulturellt perspektiv. För att uppnå ett långsiktigt uthålligt skogsbruk måste alla dessa aspekter beaktas. Uthålliga näringsbalanser i den brukade skogsmarken är nödvändiga för att bevara produktionsförmågan samt minska risken föSweden's forests are one of its most important natural resources, as well as being important from ecological and social perspectives. Nutrient sustainability is essential to maintain the production capacity and reduce the effects of acidification and eutrophication. Nutrient sustainability is strongly affected by anthropogenic influences such as air pollution and forestry practices. Regional asses

The denitrification process was studied in a stirred lab-scale suspended carrier biofilm reactor at low temperatures (3–20°C). The reactor was filled to 50% with Kaldnes K1 carriers. The denitrification rate showed only a rather weak dependence on the temperature, the rate at 3°C being approximately 55% of that at 15°C. The maximum denitrification rate obtained at 15°C was 2.7 g NOx−-N m−2 carrier

The method of calculating diffusion coefficients in gel beads based on transient experiments of solute uptake from a finite volume has been studied theoretically. Monte Carlo simulation was used to investigate the effect of random errors in the concentration measurements. The influence of sampling frequency and diffusion direction was investigated. Systematic errors derived from an assumption of c

Activity determination from scintillation camera images using the conjugate view method may be inaccurate because of variation in scattered radiation from adjacent organs and activity from overlapping tissues. The aim of this study was to simulate patient scintillation camera images and from these evaluate the accuracy of 2 correction methods. The contribution from overlapping tissue activity was

This thesis is based on a close reading of Lawrence's novel The Trespasser from a Nietzschean point of view. By adopting this perspective it aims at giving the novel the sense of unity it has so far been alleged to lack. The analysis is preceded by a detailed discussion of the concept of literary influence. Since the purpose of this study is to illuminate what is unique in Lawrence's novel rather

Abstract is not available

An experiment was designed to resolve two largely unaddressed questions about the turnover of N in soils. One is the influence of microbial growth rate on mobilization and remineralization of cellular N. The other is to what extent heterotrophic immobilization of NO3- is controlled by the soil concentration of NH4+. Bacteria were extracted from a deciduous forest soil and inoculated into an aqueou

The visual system of nocturnal Hedyloidea butterflies was investigated for the first time, using light and electron microscopy. This study was undertaken to determine whether hedylids possess the classic superposition eye design characteristic of most moths, or apposition eyes of true butterflies (Papilionoidea), and, to gain insights into the sensory ecology of the Hedyloidea. We show that Macros

The aim was to investigate the influence of age and gender on quality of life (QoL), complaints, and the presence and nature of self-reported diseases in persons aged 75 and older with cancer (n = 150), compared to a matched group without cancer (n = 138). A second aim was to investigate factors associated with poor QoL in people aged 75 and older. QoL was measured with Short Form (SF-12) and Euro

Purpose: The expression and regulation of the different isoforms of nitric oxide synthase (NOS) in bladder smooth muscle cells are controversial and to our knowledge have not yet been studied systematically. Therefore, the expression and regulation of NOS were studied in rat bladder smooth muscle cells after stimulation with cytokines, lipopolysaccharide and L-arginine. Materials and Methods: Prim