Purpose: Ultrahypofractionated (UHF) radiation therapy (RT) has become a treatment alternative for patients with localized prostate cancer. In more advanced cases, seminal vesicles (SVs) are routinely included in the target volume. The Scandinavian HYPO-RT-PC trial, which compared 42.7 Gy in 7 fractions (fr) to conventional fractionation (CF), did not include SVs in the clinical target volume. The

Aim: MicroRNAs (miRNAs) regulate β-cell function, and β-cell mitochondria and insulin secretion are perturbed in diabetes. We aimed to identify key miRNAs regulating β-cell mitochondrial metabolism and novel β-cell miRNA-mitochondrial pathways. Methods: TargetScan (http://www.targetscan.org/) was used to predict if 16 miRNAs implicated in β-cell function target 27 cis-eGenes implicated in mitochon

Background and purpose: Recent progress in diagnostics and treatment of metastatic cancer patients have improved survival substantially. These developments also affect local therapies, with treatment aims shifting from short-term palliation to long-term symptom or disease control. There is consequently a need to better define the value of stereotactic body radiotherapy (SBRT) for the treatment of

Boreal forests play a crucial role in global carbon sequestration and storage, yet their vulnerability to climate change remains a significant concern. We present results from simulations with the process-based dynamic global vegetation model LPJ-GUESS of the combined effects of climate change and forest management on the carbon sink capacity of a boreal forest in southern Sweden. We compared two

Aim: To conduct the first revision of the World Health Organization International Classification of Functioning, Disability and Health (ICF) Core Sets for attention-deficit/hyperactivity disorder (ADHD). Method: A Delphi-like method was used, integrating evidence from stakeholder feedback and developing and piloting the ADHD ICF Core Set platform to inform revisions to the ADHD Core Sets. Results:

Previous research notes difficulties in functioning and low quality of life (QoL) among transition-age youth on the autism spectrum, and poor mental health may contribute to these difficulties. This study examined the role of autism symptom severity and mental health problems on self-reported functioning and QoL in treatment-seeking transition-age autistic youth. The study included 140 autistic yo

Chemical signals are known to influence interactions within and among species of aquatic organisms, including gastropods. However, despite the indispensable roles of chemical signals in species interactions, little is known about their effectiveness, especially in gastropods. The rapa whelk Rapana venosa (Valenciennes, 1846) is an ecologically and economically important gastropod, but it has also

Cerebrospinal fluid (CSF) biomarkers reflect brain pathophysiology and are used extensively in translational research as well as in clinical practice for diagnosis of neurological diseases, e.g., Alzheimer’s disease (AD). However, CSF biomarker concentrations may be influenced by non-disease related inter-individual variability. Here we use a data-driven approach to demonstrate the existence of in

INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n =

I denne bog forsøger forfatteren at afmontere de benspænd (krokben), som den svensktalende typisk oplever i mødet med dansktalende. Det drejer sig først og fremmest om den største sten i sprogforståelsen, nemlig den danske udtale, og den lidt mindre sten, det lumske ordforråd. Mange ord deler vi allerede, men der er også ord og vendinger, der komplicerer kommunikationen danskere og svenskere imell

Consumers’ ethical efforts are capped by unethical market forces. A longitudinal study of anti-consumers shows that when systemic support was removed, consumers previously fully committed to ethical lifestyles, exhibited symptoms of an ethical consumption gap, suggesting the problem lies not with the individual (gap) but with the context (cap).

Over-indebtedness—a situation in which individuals are unable to pay their expenses and debts get out of control—is increasing among young adults in Sweden, and predictions suggest that the problem will escalate after the COVID-19 pandemic. In this chapter we draw on our experience of initiating an ethnographic study of over-indebtedness among young adults during the COVID-19 pandemic, when opport

The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor for FOL-005 and the more stable analogue FOL-026. X-ray diffraction and microscale thermophoresis analysis revealed that FOL-026 shares binding si

Background: All-cause and AIDS-mortality in Europe has been decreasing between 1996 and 2020. However, regional differences as well as their drivers remain unclear. This study investigates mortality differences and their drivers, including usage of and response to antiretroviral therapy (ART) and active tuberculosis (TB), among people with HIV across Europe. Methods: People with HIV enrolled in Eu

This study aimed to compare long-term morbidity in patients with pulmonary atresia with intact ventricular septum (PA-IVS)treated with catheter-based intervention (group A) versus those undergoing heart surgery (group B) as initial intervention.Additionally, we conducted a systematic literature review on PA-IVS treatment. All neonates born in Sweden with PA-IVSbetween 2007 and 2019 were screened f

BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,