The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towards the basal breast cancer subtype. High-throughput miRNA profiling was carried out 15, 36 and 60 h

Large herbivores can control plant community composition and, under certain conditions, even induce vegetation shifts to alternative ecosystem states. As different plant assemblages maintain contrasting carbon (C) cycling patterns, herbivores have the potential to alter C sequestration at regional scales. Their influence is of particular interest in the Arctic tundra, where a large share of the wo

That export-led industry sets the wage norm for the whole economy, acting as the “wage leader”, is a celebrated part of the Swedish wage bargaining and labour market model. Export- led wage leadership is assumed to lead to controlled, non-inflationary wage increases, as wages are set with international competition in mind. This paper maps the origins of this export industry wage leadership model,

The migration strategies of smaller, south European, Mediterranean birds are less well known than those of northern and central European birds. We used geolocators to map individual spatiotemporal migration schedules of three species breeding in the Iberian Peninsula: The White-rumped Swift Apus caffer, rufous-tailed Scrub-robin Cercotrichas galactotes and Bluethroat Cyanecula svecica. The three s

Multifractal (MF) analysis is applied for the description of spatial nanoforms which form a relief on a surface of heterostructures of ZnxCd1-xTe solid solution – substrate Si (1 1 1) synthesized by the method of the electron beam with the evaporating anode. The input data for the MF analysis were the AFM (atomic force microscopy) images of the surface of layers. Comparison of parameters of MF spe

Coming to appropriately appreciate the meaning of algebraic signs is an important aspect in introductory kinematics. However, in this educational context, the “disciplinary relevant aspects“ of algebraic signs across vector and scalar representations are extremely difficult to discern. Our study explores the “relevance structure“ that one-dimensional kinematics problems evoked for introductory lev

Cloud computing has become a compelling paradigm built on compute and storage virtualization technologies. The current virtualization solution in the Cloud widely relies on hypervisor-based technologies. Given the recent booming of the container ecosystem, the container-based virtualization starts receiving more attention for being a promising alternative. Although the container technologies are g

Safe drinking water is delivered to the consumer through kilometres of pipes. These pipes are lined with biofilm, which is thought to affect water quality by releasing bacteria into the drinking water. This study describes the number of cells released from this biofilm, their cellular characteristics, and their identity as they shaped a drinking water microbiome. Installation of ultrafiltration (

We consider steady three-dimensional gravity–capillary water waves with vorticity propagating on water of finite depth. We prove a variational principle for doubly periodic waves with relative velocities given by Beltrami vector fields, under general assumptions on the wave profile.

This work reports on a study of chemical kinetic modelling of ammonia/hydrogen/air ignition, premixed flame propagation and NO emission. A survey of chemical mechanisms available in the literature was first conducted, and the performance of 10 mechanisms was analysed in terms of the prediction of shock tube ignition delay times, laminar flame speeds and NO x concentrations for NH 3 /air and NH

The fresh re-keying scheme is a countermeasure designed to protect low-cost devices against side-channel attacks. In this paper, we present a new birthday-type attack based on a refined reduction to RING-LPN with a reducible polynomial. Compared with the previous research, our algorithm significantly reduces the time complexity in the 128-bit leakage model—with an SNR equal to 8.21 and at most 2

Stringent phosphorus discharge standards (i.e. 0.15–0.3 g P.m −3 ) in the Baltic area will compel wastewater treatment practice to augment enhanced biological phosphorus removal (EBPR) with chemical precipitation using metal salts. This study examines control of iron chemical dosing for phosphorus removal under dynamic loading conditions to optimize operational aspects of a membrane biological r

The sharing economy is a new form of resource distribution that is affecting traditional markets, cities and individuals, and challenging the prevalent regulatory frameworks, social norms and belief systems. While studies have examined some of its disruptive effects on institutional actors, there has been less focus on the ways in which sharing economy organisations work to create new or disrupt p

In this work the impact of molecular inter-linker size on gold nanoparticle (AuNP) mono-/multilayer structural properties, density and homogeneity has been investigated. These characteristics are of great importance for functional binding of biomolecules. Positively charged high or low molecular weight inter-linkers, poly-L-lysine (PLL) or N-(6-mercapto)hexylpyridinium (MHP), were used to attach n

With use of innovative proxies and new annual data, I demonstrate that relatively high legal capacity and regulatory activity of the early-modern Polish parliament, the Seym, was positively associated with deeper domestic commodity market integration. Conversely, the lack of effective law-making, caused by the right of a single delegate to discontinue the Seym's sessions, fostered market fragmenta

Scanning Laue microdiffraction was used to study the evolution of the microstructure and the stress field around two tin whiskers during ageing for up to 21 months. In the heterogeneous stress fields obtained, localised ridges of high compressive stress leading to the root of the whiskers were found. Due to the evolution of the intermetallic compound in the interface between the copper substrate a