The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P <

Sera from 40 Swedish children diagnosed as having Type 1 (insulin-dependent) diabetes mellitus during a one year period along with 40 age and geographically matched control subjects were tested for antibodies to a Mr-64000 islet protein by immunoprecipitation of 35S-methionine-labelled rat islet amphiphilic proteins. Of the 40 diabetic patients, 29 (73%) were found to be positive whereas all 40 co

The β-cell function in the perfused pancreas, the total pancreatic insulin content, and the weights of pancreas, kidney, spleen, and total body fat were compared at the age of 30 and 45 days in diabetes-prone and body weight-matched diabetes-resistant male BB rats. These inbred rats had an incidence rate of diabetes at 90 days of age of 80 and 0%, respectively. At day 30, the pancreatic insulin co

The pattern of fall in B-cell function measured as plasma and 24 h urinary C-peptide excretion, as well as levels of islet cell antibodies, insulin antibodies and metabolic parameters, were followed for two years in 39 children aged 1-17 years prospectively from clinical onset of Type 1 (insulin-dependent) diabetes. At onset 32/36 patients had measurable plasma C-peptide (median 0.13 nmol/l). Maxi

Diabetes was induced in BALB/c mice by four injections of a subdiabetogenic dose (40 mg/kg) of streptozotocin in combination with CFA. The treatment increased the plasma glucose from 5.8 ± 0.1 to 22.1 ± 1.3 mmol/liter (n = 9). The diabetic animals had circulating islet cell surface antibodies (75%), and a monoclonal islet cell surface IgM antibody, K56aF3, generated from one of the diabetic BALB/c

Rwanda har sedan 2006 aktivt arbetat för att modernisera jordbrukssektorn med syftet att ersätta småskaliga självförsörjande jordbruk med moderna, marknadsorienterade. I denna process har småskaliga jordbrukare tvingats att överge sina traditionella grödor och jordbruksmetoder för att anpassa sig till odling i monokultur utvalt av staten på sammanslagna jordlotter.Avhandlingen, baserad på 13 månadSince 2006, Rwanda has been implementing policies to modernize the agricultural sector, with the aim of moving from small-scale subsistence farming to modern, market-oriented farming. Under these policies, small-scale farmers have been compelled to abandon their traditional farming practices and adapt to monocropping of state-approved crops on consolidated land.This dissertation, based on 13 month

Background: Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Methods: This observational study included data from the Optimum Patient Care Research

This book offers a unique analysis of the use of the automated facial recognition algorithms that are increasingly intervening in our society from a critical visual culture studies perspective. The discussion focuses on the visuality of automated facial recognition and its designed algorithms as a case study in machinic vision and its concurrent modes of perception. It focuses on a general problem

Bacteriophages, or phages, are viruses that infect bacteria, at the end of their life cycle produce a set of enzymes called endolysins to lyse host cells from within, facilitating the release of the viral progeny. Due to their lytic activity, endolysins have gained great interest as potential antibacterials targeting both Gram–positive and –negative bacteria, especially in the actual context of in

Den statliga förvaltningen i dess olika skepnader har sedan länge mycket stor betydelse för samhället och enskilda i de nordiska länderna. En central fråga i offentlig rätt och statsvetenskap är hur förvaltningens ställning i samhället ska förstås. I ett offentligrättsligt perspektiv handlar det då bland annat om förvaltningens konstitutionella eller statsrättsliga roll. Hur fastställs de rättslig

Background: Health professions education programs are tasked with designing curricula to effectively andefficiently equip their graduates with the required competences and life-long learning skills needed fortoday’s fast-paced, knowledge intensive society. Continuous monitoring and improving of educationalquality is essential to attain these goals. Quality assurance is multi-faceted and requires t

Background: The power and influence of the hidden curriculum - culturally situated norms and values - onlearning opportunities is a growing concern in medical education. However, while medical schools producediversity and equal treatment policies, efforts towards surfacing and addressing equal opportunities in theclinical learning environment trail behind.Summary of Work: To better understand how