Hypoxia-inducible factors (HIFs) are differentially regulated in tumor cells. While the current paradigm supports post-translational regulation of the HIF-α subunits, we recently showed that hypoxic HIF-2α is also transcriptionally regulated via insulin-like growth factor (IGF)-II in the childhood tumor neuroblastoma. Here, we demonstrate that transcriptional regulation of HIF-2α seems to be restr

In Sweden, evidence-based national guidelines for the indication for reduction mammaplasty in the public health-care system have been developed by a group of experts. They were defined as breast volume ≥800 ml at normal weight. Furthermore, a volume asymmetry of 25% or at least 200 ml or an extreme ptosis may be an indication in some cases. The aim of the present paper was to describe an easy-to-u

Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. Methods: Protein physical interactions were screened using the yeast two-hybrid syst

Successful innovation strategy relies on experience gained from a complexity of understanding, anticipating and managing the global business environment. But, although much research has examined strategies of private sector organizations in Western economies, there are relatively few studies of innovation in public sector organizations of transitional and protected economic environments, such as I

The electromagnetic polarizabilities of the nucleon are fundamental properties that describe its response to external electric and magnetic fields. They can be extracted from Compton-scattering data-and have been, with good accuracy, in the case of the proton. In contradistinction, information for the neutron requires the use of Compton scattering from nuclear targets. Here, we report a new measur

PurposeTo investigate the diagnostic accuracy and clinical usefulness of the rim sign in breast lesions observed in diffusion-weighted magnetic resonance imaging (DWI). Materials and MethodsThe magnetic resonance imaging (MRI) findings of 98 pathologically confirmed lesions (62 malignant and 36 benign) in 84 patients were included. Five breast radiologists were asked to independently review the br

The atomic and electronic structure of graphene synthesized on commercially available cubic-SiC(001)/Si(001) wafers have been studied by low energy electron microscopy (LEEM), scanning tunneling microscopy (STM), low energy electron diffraction (LEED), and angle resolved photoelectron spectroscopy (ARPES). LEEM and STM data prove the wafer-scale continuity and uniform thickness of the graphene ove

Ischemic stroke triggers neurogenesis from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) and migration of newly formed neuroblasts towards the damaged striatum where they differentiate to mature neurons. Whether it is the injury per se or the associated inflammation that gives rise to this endogenous neurogenic response is unknown. Here we showed that inflammation without c

The role of weakly chirped pulses (time bandwidth product, DeltanuDeltatau

The traditional Furongian trilobite biozones of Scandinavia, recently proposed abandoned due to inconsistent boundary definitions [Terfelt, F., Eriksson, M.E., Ahlberg, P. & Babcock, L.E., 2008: Furongian Series (Cambrian) biostratigraphy of Scandinavia - a revision. Norwegian Journal of Geology88, 73-87], are resurrected and elevated to superzonal rank. These superzones are usually readily re

This article demonstrates how gender is implicated in climate governance through insights derived from gender and transition studies in combination, applied and illustrated through a study of climate governance in Sweden. The approach is constructive and uses central analytical concepts: transition arenas, niches, regimes and landscapes together with insights from gender research. The article prop

In search for more powerful unit root tests, some researchers have recently proposed accounting for the information contained in the GARCH of the innovations. However, while promising, tests with GARCH are difficult to implement, which has made them quite uncommon in the empirical literature. A computationally attractive alternative is to account not for GARCH but the information contained in a pa

Previous studies have shown that fossil energy systems can be a conflict objective, means or cause. This study explores how renewable energy (RE) systems can interact with conflicts and to what extent the risk of different conflicts may change. Renewable resources, in contrast to conventional fossil resources, are more difficult to control in time and space. RE systems depend on exploiting flows r

This ERP study investigated the cognitive nature of the P1-N1 components during orthographic processing. We used an implicit reading task with various types of stimuli involving different amounts of sublexical or lexical orthographic processing (words, pseudohomophones, pseudowords, nonwords, and symbols), and tested average and dyslexic readers. An orthographic regularity effect (pseudowords-nonw

To reach a European consensus on the definition and characterization of the main organ-specific extraglandular manifestations in primary SS.

The use of brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs) in aircraft is the result of high fire safety demands. Personnel working in or with aircraft might therefore be exposed to several BFRs. Previous studies have reported PBDE exposure in flight attendants and in passengers. One other group that may be subjected to significant BFR exposure via inhalation, are

Mobility in public environments is an important part of people's everyday life. However, living with functional limitations often means limited mobility. To plan for public environments that enable mobility for everybody, knowledge about various user groups' mobility is important. Up until now, knowledge concerning the mobility of people with cognitive functional limitations has been scarce. The a

This paper concerns the operational activities of the public security organs of the People’s Republic of China (PRC) during the immediate post-1949 period of regime consolidation. The main part of the paper is a case-study of a 1950 pilot scheme to recruit agents in critical sectors of industry and trade in the city of Yingkou in Northeast China, a scheme in due course subsumed under a nationwide

Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigat