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Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 lig
This paper analyzes the adoption of Additive Manufacturing (AM) technologies in Sweden. The dataset consists of a recent and representative sample of Swedish AM users (companies, universities, and research institutes). The authors investigate two questions. Firstly, what are the current applications of AM in Sweden (e.g. Rapid Prototyping (RP), production)? Secondly, what are the factors that can
Purpose: To compare the specificity of diagnosing posterior vitreous detachment (PVD) using preoperative optical coherence tomography (OCT) versus intraoperative triamcinolone acetonide (TA) staining in patients undergoing vitrectomy. Patients and Methods: This retrospective cohort study included patients undergoing pars plana vitrectomy for diverse retinal pathologies. Intraoperatively, surgeons
Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications, however, our primary interest is not generalization but to obtain optimal predictions on a specific unlabeled database that is fully available during model development
Over the past decade, as ruling Justice and Development Party (AKP) initiated Turkey’s authoritarian populist turn, it sought to derive legitimacy through extra-institutional avenues, notably the emotional appeal to the repressed “people”, advancing the party’s socio-political vision, countering the arguments of its political opponents and reaching out to, and inspiring its constituency. Turkey’s
Background: Coronary physiology is a routine diagnostic tool when assessing whether coronary revascularization is indicated. The iFR-SWEDEHEART trial demonstrated similar clinical outcomes when using instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) to guide revascularization. The objective of this analysis was to assess a cost-minimization analysis of iFR-guided compared with F
In recent years a concept gaining much traction amongst both economic and policy communities is that of Entrepreneurial Ecosystems (EE). We are interested in this concept because it has clear roots in innovation system thinking and can be argued to represent a contemporary iteration of ideas around systemic understandings and policy approaches to economic development, innovation, and entrepreneurs
Order-batching is an important methodology in warehouse material handling. This paper addresses three identified shortcomings in the current literature on order-batching optimization. The first concerns the overly large dependence on conventional warehouse layouts. The second is a lack of proposed optimization methods capable of producing approximate solutions in minimal computational time. The th
Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (COPD) with an individualized cardiopulmonary exercise test (ICPET) and subsequent customized endurance test (CET), which generate less interindividual spread in endurance time compared with the standard endurance test. Main objectives of this study were to improve the prediction algorithm f
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.
Background: The ABILHAND questionnaire is recommended to assess perceived manual ability after stroke; however, more knowledge on interpretability is needed to improve the clinical applicability. Objectives: To determine clinically meaningful cutoff scores for different levels of perceived manual ability, assessed by ABILHAND, corresponding to established observed and perceived upper extremity ass
DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described roles during development, and tumor-supportive functions in several aggressive cancer forms. Here, we review the many functions of DLK1 as a regulator of stem cell pools and tissue differentiation in tissues such as brain, mu
Study design: Cross-sectional and longitudinal. Objectives: To (i) describe sense of coherence (SOC) and changes over six years in older adults aging with long-term spinal cord injury (SCI) and (ii) investigate how changes in SOC are associated with injury characteristics and changes in sociodemographics and secondary health conditions (SHCs; bowel-related and bladder-related problems, pain and sp
Corporate governance structures are expected to help a firm have better financial performance through giving proper decision-making (Shivani, Jain, & Yadav, 2017). In recent years, along with the completing process of the business environment, the corporate governance framework in Vietnam has also been gradually built and implemented. However, corporate governance in Vietnam still has some lim
Investigating physical activity (PA) patterns as a detailed intensity spectrum instead of crude intensity categories have improved the ability to analyze the relationship between measured PA and health variables. The aim of this methodological study was to introduce and investigate the utility of using detailed PA intensity spectrum compared to crude PA intensity categories for comparison of PA be
This paper investigates how economic expectations shape voting intentions in a hypothetical independence referendum in Greenland, a self-governing region of the Kingdom of Denmark. I identify the causal effect of economic expectations by randomly exposing respondents to a prime informing on Greenland's current fiscal deficit. Respondents exposed to the information are 43% more likely to oppose ind
In spite of the fast spread of Additive Manufacturing (AM) in several countries and industries, its impact on employment is still unexplored and theoretically ambiguous. On the one hand, higher product customisation and shorter time-to-market entail an expansion of the market, thus fostering labour demand; on the other hand, AM profoundly changes the way goods are produced and little evidence exis
Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other c
