Sökresultat

Filtyp

Din sökning på "*" gav 535696 sökträffar

From Monte Carlo PET Simulations to Reconstructed Images : Modelling and Optimisation for 68Ga Theragnostics

In nuclear medicine, radiopharmaceuticals can be administered for both diagnostic and therapeutic purposes. In recent years, there has been an increasing interest in theragnostics, a strategy that combines both diagnosis and therapy. This can be achieved by using similar radiopharmaceuticals for imaging and radionuclide therapy, which enables highly personalised disease management. One theragnosti

The boundaries of the internal market in- and outside the EU

This chapter addresses the question of the outer limits of the European Union’s (EU) internal market and its significance in the Union's foreign policy, especially in relations with the EU’s neighbouring countries. The internal market forms the core of European integration and has gained increased importance in the external context. Through an analysis of the relevance of the internal market withi

Larmor precession in strongly correlated itinerant electron systems

Many-electron systems undergo a collective Larmor precession in the presence of a magnetic field. In a paramagnetic metal, the resulting spin wave provides insight into the correlation effects generated by the electron-electron interaction. Here, we use dynamical mean-field theory to investigate the collective Larmor precession in the strongly correlated regime, where dynamical correlation effects

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

Recent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While the link between systemic metabolism and atherosclerosis is well established, the implications of altered metabolism in the artery wall are less understood. Pyruvate dehydrogenase kinase (PDK)-dependent inhibition of pyruvate dehydrogenase (PDH) has been identi

TOI-1442 b and TOI-2445 b: Two potentially rocky ultra-short period planets around M dwarfs

Context. Exoplanets with orbital periods of less than one day are known as ultra-short period (USP) planets. They are relatively rare products of planetary formation and evolution processes, but especially favourable for characterisation with current planet detection methods. At the time of writing, 125 USP planets have already been confirmed. Aims. Our aim is to validate the planetary nature of t

Soft Skills Demand and Supply Through the Lens of Higher Education Students

Soft skills are becoming equally crucial as hard skills in today's labour market. In contrast to hard skills which are teachable typically through formal education, soft skills are non-technical and interpersonal, allowing individuals to be able to find and succeed in their studies, jobs, and professional life. Despite the increasing emphasis on soft skills, many university students are either una

Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: Data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries

Objectives To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was define

Equity, Diversity and Inclusion (EDI) in Organ Transplantation : An ESOT Survey About EDI Within ESOT as an Organization and its Educational Activities, and Transplantation Research and Science

The European Society of Organ Transplantation (ESOT) strives to promote equity, diversity, and inclusion (EDI) across all its activities. We surveyed the transplant community’s experiences and perspectives regarding EDI within ESOT as an organization and its educational activities, and research in general. A total of 299 respondents completed the questionnaire. About half agreed that ESOT’s Execut

Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass

The Influence of Narrative Specificity and Voice Quality when Listening to Audio Descriptions : a Comparison of the Sighted and the Blind

Audio description (AD) serves as a vital means to make visual media accessible to non-sighted and visually impaired audiences. This study systematically investigates the impact of narrative specificity and voice quality on imageability and comprehension in both sighted and non-sighted populations. Twenty non-sighted participants, including congenitally blind individuals and those who lost their siAudio description (AD) serves as a vital means to make visual media accessible to non-sighted and visually impaired audiences. This study systematically investigates the impact of narrative specificity and voice quality on imageability and comprehension in both sighted and non-sighted populations. Twenty non-sighted participants, including congenitally blind individuals and those who lost their si

Clonal haematopoiesis and risk of chronic liver disease

Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 indep

A STATISTICAL META-ANALYSIS OF LITHOLOGIC AND OTHER POTENTIAL CONTROLS ON FOSSIL BONE CELLULAR AND SOFT TISSUE PRESERVATION

Demineralization assays, utilizing weak acids to isolate organics from biomineralized tissues, have recently been applied with increasing frequency to explore soft tissue preservation in fossils, revealing frequent retention of cells and other pliable microstructures in fossil bones. However, factors controlling long-term preservation of such labile structures remain mysterious. To address this, w

Metabolic control by AMPK in white adipose tissue

White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK a

Eosinophils and tissue remodeling : Relevance to airway disease

The ability of human tissue to reorganize and restore its existing structure underlies tissue homeostasis in the healthy airways, but in disease can persist without normal resolution, leading to an altered airway structure. Eosinophils play a cardinal role in airway remodeling both in health and disease, driving epithelial homeostasis and extracellular matrix turnover. Physiological consequences a

Nonsynonymous Synonymous Variants Demand for a Paradigm Shift in Genetics

Synonymous (also known as silent) variations are by definition not considered to change the coded protein. Still many variations in this category affect either protein abundance or properties. As this situation is confusing, we have recently introduced systematics for synonymous variations and those that may on the surface look like synonymous, but these may affect the coded protein in various way

Oxidation and Reconstructions of Alloy Model Catalysts : Platinum-Rhodium and Palladium-Gold

Alloys and bimetallic systems have shown many advantages in heterogeneous catalysis, but the details of their catalytic functions are not always known. For instance, the atomic details about surface reconstructions under catalytic reaction conditions, or which phases that are high-active or low-active. Furthermore, the model catalysts studied in laboratories often differ a lot from the industrial

Optimal Inverse Design Based on Memetic Algorithms - Part 1 : Theory and Implementation

A memetic framework for optimal inverse design is proposed by combining a local gradient-based procedure and a robust global scheme. The procedure is based on method-of-moments matrices and does not demand full inversion of a system matrix. Fundamental bounds are evaluated for all optimized metrics in the same manner, providing natural stopping criteria and quality measures for realized devices. C

Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia

Introduction: The suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic methods. Methods: For this purpose, we assessed the analytical performance of 150 bp paired-end WGS (90x leukemia/30x germline). A set of 88 retrospective B-cell