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Fermentative lifestyle in yeasts belonging to the Saccharomyces complex

The yeast Saccharomyces cerevisiae is characterized by its ability to: (a) degrade glucose or fructose to ethanol, even in the presence of oxygen (Crabtree effect); (b) grow in the absence of oxygen; and (c) generate respiratory-deficient mitochondrial mutants, so-called petites. How unique are these properties among yeasts in the Saccharomyces clade, and what is their origin? Recent progress in g

Life events, social support and sense of coherence among frequent attenders in primary health care

Objectives: The aim of this survey was to compare stressful life events, social support and sense of coherence (SOC) between frequent attenders (FAs) and normal attenders (controls) in primary health care. Study design: A cross-sectional study was conducted in a primary healthcare centre in the south-west of Sweden. Methods: A postal questionnaire was sent to 263 frequent attenders and 703 normal

Neonatal chronic sympathectomy in normotensive rats affects pial arteries: enhanced stiffness and reduced capacity to dilate

The functional implication of previously shown effects on pial wall morphology by sympathectomy was tested. Following either ganglionic or pre-ganglionic denervation in 1-week-old rats the passive arterial compliance was reduced in basal cerebral arteries of 20-week-old normotensive, but not of hypertensive animals. The magnitude of the denervation induced stiffness was similar to the alteration s

XUV interferometry using high-order harmonics: Application to plasma diagnostics

In this paper, we present and compare the two different XUV interferometric techniques using high-order harmonics that have been developed so far. The first scheme is based on the interference between two spatially separated phase-locked harmonic sources while the second uses two temporally separated harmonic sources. These techniques have been applied to plasma diagnostics in feasibility experime

(K4Li4)Al8Ge8O32 8H(2)O, an Li+-exchanged potassium alumino-germanate with the zeolite gismondine (GIS) topology

The title compound, lithium potassium dialuminium diger-manium octaoxide dihydrate, (K,Li)-(Al,Ge)-GIS (GIS is gismondine), is the result of a 50% Li+ exchange into the K-(Al,Ge)- GIS structure. The (K,Li)-(Al,Ge)-GIS structure was determined from a 4 x 4 x 2 m m octahedral single crystal at the ESRF synchrotron X-ray source. The ion exchange results in a symmetry transformation from I2/a for K-(A

Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men

Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultra

Singular Integral Equations: Applications to Elasticity and Numerical Solution

The purpose of this thesis is to develop stable, accurate, and efficient numerical algorithms for the solution of certain problems in materials science using integral equations. All the appearing integral equations are of the second kind. Such equations are typically well suited for numerical solution. The second kind equations are obtained from first kind equations through analytical regularizati

Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidhAbstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen in hepatic cell systems, is als