Hydroxide ion conducting poly(terphenyl alkylene)s functionalized with piperidine-based quaternary ammonium cations were synthesized via superacid-catalyzed polyhydroxyalkylations. By employing different synthetic strategies, we have systematically varied the structures of the cation and the backbone polymer to study the effects on morphology, stability and hydroxide conductivity. Two monomers wer

The bacterial superantigen staphylococcal enterotoxin A (SEA) is a potent inducer of cytokine production and cytotoxic T cell responses. To target a T cell attack against tumor cells we have genetically engineered a fusion protein of SEA and the Fab part of the tumor-reactive mAb C215. Injection of this Fab-SEA fusion protein to mice carrying lung metastases of the poorly immunogenic B16 melanoma

In a population of Blue Tits, Parus caeruleus, we performed two different food provisioning experiments; one starting before clutch initiaition and one starting when the first eggs were laid. We assessed the effect of these feeding experiments on four fitness—related factors, viz., laying date, clutch size, egg mass, and onset of incubation. Given that breeding birds are food and energy constraine

Gender lay theory is a framework of information interpretation related to gender categorisation and can be divided into twogeneral forms: gender essentialism versus gender as socially constructed. The present study investigated how exposure toscientifically framed explanations for gender differences affects individuals’ gender lay theory and if endorsement of an essentialist gender lay theory inflGender lay theory is a framework of information interpretation related to gender categorisation and can be divided into twogeneral forms: gender essentialism versus gender as socially constructed. The present study investigated how exposure toscientifically framed explanations for gender differences affects individuals’ gender lay theory and if endorsement of an essentialist gender lay theory infl

Previous reports showed that nontypeable Haemophilus influenzae (NTHi) reside in macrophage-like cells in human adenoid tissue. This study investigated the ability of nonopsonized NTHi and encapsulated H. influenzae type b (Hib) to enter human monocytic and epithelial cells. The number of intracellular bacteria was determined by a viability assay and flow cytometry. To characterize the mechanisms

In this work, we propose to utilize a recently developed covariance matrix interpolation technique in order to improve noise reduction in multi-microphone setups in the presence of a moving, localized noise source. Based on the concept of optimal mass transport, the proposed method induces matrix interpolants implying smooth spatial displacement of the noise source, allowing for physically reasona

The extracellular homeostasis of glutamate in the brain is maintained by the efficient uptake into astroglial cells. The high extracellular glutamate levels seen during seizures are therefore probably a result of both an increased synaptic release and a deranged glutamate uptake. In this study we used immuno-blotting technique to measure the cortical levels of the astrocytic glutamate transport pr

A duster of a Neisseria meningitidis serogroup C strain causing invasive disease was investigated. Five out of seven cases were associated with a particular discotheque. The strains were indistinguishable, as revealed by pulsed-field gel electrophoresis and sequencing of variable regions of the porA gene, but caused strikingly different clinical presentations during 5 months.

Tissue factor pathway inhibitor (TFPI) is one of the main regulators of the tissue factor (TF) pathway of coagulation. To tether human TFPI to the cell surface, full length or truncated TFPI lacking the third Kunitz domain were fused with domains three and four and the carboxy-terminal sequence of human CD4. Constructs were transfected into a mouse fibroblast cell line and individual clones were c