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Obstetric management of intrauterine growth restriction.

The aim of obstetric management is to identify growth-restricted foetuses at risk of severe intrauterine hypoxia, to monitor their health and to deliver when the adverse outcome is imminent. After 30-32 gestational weeks, a Doppler finding of absent or reverse end-diastolic flow in the umbilical artery of a small-for-gestational age foetus is in itself an indication for delivery. In very preterm f

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.

Although Parkinson's disease is a movement disorder, in many patients cognitive dysfunction is an important clinical sign. It is not yet clear whether this is attributable solely to a decrease in dopamine levels, or whether other neurotransmitter systems might be involved as well. In the present study, the importance of the mesocorticolimbic dopamine pathway and a possible convergence with forebra

Multiphysics modelling of PEM fuel cells - with reacting transport phenomena at micro and macroscales

Popular Abstract in Swedish Polymermembranbränsleceller (PEM) anses vara en mycket lovande teknik inom fordonsindustrin på grund av dess kompakthet i storlek, höga verkningsgrader samt låga arbetstryck och temperaturer. De senaste åren har tekniken varit fokus för en anseenlig mängd forskning. PEM-bränsleceller har den stora fördelen att energiomvandlingseffektiviteten har potential för att vara bThis thesis presents numerical simulations of reacting transport phenomena in polymer electrolyte membrane (PEM) fuel cells. Broadly, the presented work is subdivided into macro and microscale simulations. In macroscale simulations, a unit PEM fuel cell with interdigitated flow field configurations is simulated keeping in mind all the essential transport mechanisms, i.e., transport of species, ion

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.

Aims Baseline adiponectin concentrations predict incident Type 2 diabetes mellitus in the Diabetes Prevention Program. We tested the hypothesis that common variants in the genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1, ADIPOR2) would associate with circulating adiponectin concentrations and/or with diabetes incidence in the Diabetes Prevention Program population. Methods Seventy-s

Signal Modeling and Detection in Nephrologic and Cardiac Applications

This doctoral thesis is comprised of five parts in the field of biomedical signal processing with focus on methods for use in hemodialysis as well as in cardiac applications. The problem of predicting hypotension is the main concern in the parts were data from patients undergoing hemodialysis are used. In Part I, a newly developed method for heart rate variability (HRV) analysis in the presence of

Phonetic markedness, turning points, and anticipatory attention

Phonetic markedness regarding linguistically relevant tonal patterns (Accent 2, boundary tones) in Central Swedish is discussed. Both tonal markedness and F0 turning points are assumed to be important cues for anticipatory attention to grammatical structure during speech processing. Empirical evidence from neuro- linguistic and psycholinguistic experiments for the assumed relation between anticipa

Information management in industrial housing design and manufacture

Industrialized production of building components, or entire houses, reduces activities at the construction site to the assembly of parts and has the potential to increase productivity and reduce the design effort invested in every project. However, in order to realize all of the potential efficiency gains that use of predefined components could deliver effective, interoperable information manageme

The liver in 30-year-old individuals with alpha(1)-antitrypsin deficiency.

OBJECTIVE. Severe (PiZZ) alpha(1)-antitrypsin (AAT) deficiency is a risk factor for liver disease, i.e. juvenile cirrhosis in infancy, and cirrhosis and hepatoma in adulthood. Little is known about the risk of liver disease in individuals with moderate (PiSZ) AAT deficiency. To investigate the natural course of AAT deficiency, a cohort of PiZZ and PiSZ individuals identified by the Swedish Nationa

Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.

There is a functional relationship between the heparan sulfate proteoglycan glypican-1 and the amyloid precursor protein of Alzheimer disease. In wild-type mouse embryonic fibroblasts, expression and processing of the amyloid precursor protein is required for endosome-to-nucleus translocation of anhydromannose-containing heparan sulfate released from S-nitrosylated glypican-1 by ascorbate-induced,

The weaknesses of the tongue arching model of vowel articulation

In 1867 Alexander Melville Bell conceived the high-low front-back tongue position model for vowels, including the concept of central vowels. This model was rapidly accepted by the phonetics community, but it has never been validated. This article reports an examination of 38 sets of X-ray tracings of vowels from 15 different languages, published in the past half century. This corroborates the char